STRINGSTRING
CAMKK2 CAMKK2 ABCG5 ABCG5 APOB APOB FGF21 FGF21 APOE APOE PPARG PPARG UCP2 UCP2 FOXO1 FOXO1 FASN FASN ULK1 ULK1 NCOR2 NCOR2 SOAT2 SOAT2 GPAT3 GPAT3 GCG GCG CPT1A CPT1A ESRRA ESRRA THRA THRA SHBG SHBG ACACA ACACA AKT1 AKT1 PRKACB PRKACB TFAM TFAM NRF1 NRF1 THRB THRB HNF4A HNF4A FDPS FDPS NCOR1 NCOR1 PRKACA PRKACA PPARA PPARA ABCG8 ABCG8 SCARB1 SCARB1 TFEB TFEB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (859 aa)
ABCG5ATP binding cassette subfamily G member 5. (652 aa)
APOBApolipoprotein B. (4326 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (336 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (529 aa)
UCP2Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). (309 aa)
FOXO1Forkhead box O1. (654 aa)
FASNFatty acid synthase. (2478 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1004 aa)
NCOR2Nuclear receptor corepressor 2. (2517 aa)
SOAT2O-acyltransferase. (530 aa)
GPAT3Glycerol-3-phosphate acyltransferase 3. (433 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
CPT1AUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
ESRRASteroid hormone receptor ERR1; Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium- chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. May function as a modulator of the estrogen signaling pathway in the uterus. Induces the expression of PERM1 in the skeletal muscle (By similarity). Belongs to the nuclear hormone receptor family. NR3 subfamily. (613 aa)
THRAUncharacterized protein. (511 aa)
SHBGSex hormone binding globulin. (405 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
TFAMTranscription factor A, mitochondrial. (246 aa)
NRF1Nuclear respiratory factor 1. (556 aa)
THRBThyroid hormone receptor beta. (476 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (484 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (470 aa)
NCOR1Nuclear receptor corepressor 1. (2542 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)
PPARAPeroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] (568 aa)
ABCG8ATP binding cassette subfamily G member 8. (707 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (552 aa)
TFEBTranscription factor EB. (566 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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