29 items (Canis lupus familiaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	MLST8	MTOR associated protein, LST8 homolog. (326 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	FOXO3	Forkhead box O3. (671 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	EGFR	Receptor protein-tyrosine kinase. (1141 aa)
	CHRNA5	Cholinergic receptor nicotinic alpha 5 subunit. (431 aa)
	SIRT1	Sirtuin 1. (745 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (291 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (372 aa)
	WRN	WRN RecQ like helicase. (1574 aa)
	TRPV1	Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (840 aa)
	GHRL	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (117 aa)
	TINF2	TERF1 interacting nuclear factor 2. (452 aa)
	LOC480110	Histone H3; Belongs to the histone H3 family. (136 aa)
	XRCC5	X-ray repair cross complementing 5. (829 aa)
	SIRT6	Sirtuin 6. (403 aa)
	LOC612779	Histone H3; Belongs to the histone H3 family. (136 aa)
	NDUFB5	NADH:ubiquinone oxidoreductase subunit B5. (189 aa)
	LOC111090006	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC488263	Histone H3; Belongs to the histone H3 family. (136 aa)
	BECN1	Beclin 1. (471 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1253 aa)
	RHEB	Ras homolog, mTORC1 binding. (232 aa)
	H3C13	Histone H3. (136 aa)
	GHR	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). (645 aa)
	ASXL2	ASXL transcriptional regulator 2. (1461 aa)
	XRCC6	X-ray repair cross complementing 6. (612 aa)
	EPRS1	Glutamyl-prolyl-tRNA synthetase. (1516 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASXL2	CHRNA5	ENSCAFP00000057584	ENSCAFP00000002540	ASXL transcriptional regulator 2.	Cholinergic receptor nicotinic alpha 5 subunit.	0.483
ATG5	BECN1	ENSCAFP00000005515	ENSCAFP00000047143	Autophagy protein 5; Involved in autophagic vesicle formation.	Beclin 1.	0.976
ATG5	FOXO3	ENSCAFP00000005515	ENSCAFP00000005627	Autophagy protein 5; Involved in autophagic vesicle formation.	Forkhead box O3.	0.481
ATG5	RHEB	ENSCAFP00000005515	ENSCAFP00000050252	Autophagy protein 5; Involved in autophagic vesicle formation.	Ras homolog, mTORC1 binding.	0.475
ATG5	SIRT1	ENSCAFP00000005515	ENSCAFP00000019617	Autophagy protein 5; Involved in autophagic vesicle formation.	Sirtuin 1.	0.677
ATG5	SIRT3	ENSCAFP00000005515	ENSCAFP00000009649	Autophagy protein 5; Involved in autophagic vesicle formation.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.458
ATG5	SIRT6	ENSCAFP00000005515	ENSCAFP00000038856	Autophagy protein 5; Involved in autophagic vesicle formation.	Sirtuin 6.	0.478
ATG5	TP53	ENSCAFP00000005515	ENSCAFP00000064590	Autophagy protein 5; Involved in autophagic vesicle formation.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.580
BECN1	ATG5	ENSCAFP00000047143	ENSCAFP00000005515	Beclin 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.976
BECN1	EGFR	ENSCAFP00000047143	ENSCAFP00000005164	Beclin 1.	Receptor protein-tyrosine kinase.	0.502
BECN1	FOXO3	ENSCAFP00000047143	ENSCAFP00000005627	Beclin 1.	Forkhead box O3.	0.474
BECN1	RHEB	ENSCAFP00000047143	ENSCAFP00000050252	Beclin 1.	Ras homolog, mTORC1 binding.	0.504
BECN1	SIRT1	ENSCAFP00000047143	ENSCAFP00000019617	Beclin 1.	Sirtuin 1.	0.617
BECN1	SIRT3	ENSCAFP00000047143	ENSCAFP00000009649	Beclin 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.407
BECN1	TP53	ENSCAFP00000047143	ENSCAFP00000064590	Beclin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.753
CHRNA5	ASXL2	ENSCAFP00000002540	ENSCAFP00000057584	Cholinergic receptor nicotinic alpha 5 subunit.	ASXL transcriptional regulator 2.	0.483
EGFR	BECN1	ENSCAFP00000005164	ENSCAFP00000047143	Receptor protein-tyrosine kinase.	Beclin 1.	0.502
EGFR	FGF21	ENSCAFP00000005164	ENSCAFP00000005813	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.813
EGFR	IGFBP3	ENSCAFP00000005164	ENSCAFP00000018107	Receptor protein-tyrosine kinase.	Insulin like growth factor binding protein 3.	0.597
EGFR	RHEB	ENSCAFP00000005164	ENSCAFP00000050252	Receptor protein-tyrosine kinase.	Ras homolog, mTORC1 binding.	0.416