(5 nodes) (2021) Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis. network (Canis lupus familiaris)

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Your Input:
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
	PACC1	Transmembrane protein 206. (363 aa)
	LAMP1	Lysosomal associated membrane protein 1. (413 aa)
	EEA1	Early endosome antigen 1. (1406 aa)
	CUBN	Cubilin; Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal t [...] (3614 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEA1	LAMP1	ENSCAFP00000009251	ENSCAFP00000009494	Early endosome antigen 1.	Lysosomal associated membrane protein 1.	0.998
EEA1	VPS35	ENSCAFP00000009251	ENSCAFP00000005503	Early endosome antigen 1.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.917
LAMP1	EEA1	ENSCAFP00000009494	ENSCAFP00000009251	Lysosomal associated membrane protein 1.	Early endosome antigen 1.	0.998
LAMP1	VPS35	ENSCAFP00000009494	ENSCAFP00000005503	Lysosomal associated membrane protein 1.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.815
PACC1	VPS35	ENSCAFP00000059615	ENSCAFP00000005503	Transmembrane protein 206.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.576
VPS35	EEA1	ENSCAFP00000005503	ENSCAFP00000009251	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Early endosome antigen 1.	0.917
VPS35	LAMP1	ENSCAFP00000005503	ENSCAFP00000009494	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Lysosomal associated membrane protein 1.	0.815
VPS35	PACC1	ENSCAFP00000005503	ENSCAFP00000059615	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Transmembrane protein 206.	0.576