STRINGSTRING
ITGAV ITGAV FST FST FURIN FURIN DCSTAMP DCSTAMP SLC2A1 SLC2A1 PCNA PCNA POSTN POSTN IL36B IL36B IL36RN IL36RN MSTN MSTN DMP1 DMP1 IBSP IBSP DKK2 DKK2 CTSK CTSK ACE ACE COL1A1 COL1A1 FOS FOS ACP5 ACP5 SMAD3 SMAD3 FSTL3 FSTL3 NFATC1 NFATC1 ITGB3 ITGB3 GDF11 GDF11 UTRN UTRN COL10A1 COL10A1 IL1F10 IL1F10 IL37 IL37 SOST SOST TCF7 TCF7 SRC SRC CALCR CALCR BMP2 BMP2 ALPL ALPL SMAD2 SMAD2 IGF1 IGF1 INS INS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1033 aa)
FSTFollistatin. (237 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (827 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (807 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POSTNPeriostin. (836 aa)
IL36BInterleukin-1. (164 aa)
IL36RNInterleukin-1. (155 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
DMP1Dentin matrix acidic phosphoprotein 1. (575 aa)
IBSPIntegrin binding sialoprotein. (319 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (446 aa)
ACEAngiotensin-converting enzyme. (1307 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1460 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (343 aa)
SMAD3Mothers against decapentaplegic homolog. (611 aa)
FSTL3Follistatin like 3. (264 aa)
NFATC1Nuclear factor of activated T cells 1. (923 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (919 aa)
GDF11Growth differentiation factor 11. (288 aa)
UTRNUtrophin. (3432 aa)
COL10A1Collagen type X alpha 1 chain. (677 aa)
IL1F10Interleukin-1. (177 aa)
IL37Interleukin-1. (288 aa)
SOSTSclerostin. (213 aa)
TCF7Transcription factor 7. (484 aa)
SRCTyrosine-protein kinase. (553 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (478 aa)
BMP2Bone morphogenetic protein 2. (436 aa)
ALPLAlkaline phosphatase. (572 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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