STRINGSTRING
MMP2 MMP2 CTSS CTSS CTSK CTSK PTGS2 PTGS2 FBN1 FBN1 MMP13 MMP13 MMP8 MMP8 MMP3 MMP3 COL1A1 COL1A1 COL5A1 COL5A1 MMP9 MMP9 MMP1 MMP1 LOX LOX LTBP2 LTBP2 COL12A1 COL12A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP2Matrix metallopeptidase 2. (610 aa)
CTSSCathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). (339 aa)
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (446 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
FBN1Uncharacterized protein. (2871 aa)
MMP13Matrix metallopeptidase 13. (496 aa)
MMP8Matrix metallopeptidase 8. (476 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family. (478 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1460 aa)
COL5A1Collagen type V alpha 1 chain. (1005 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (732 aa)
MMP1Matrix metallopeptidase 1. (465 aa)
LOXLysyl oxidase. (409 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1817 aa)
COL12A1Collagen type XII alpha 1 chain. (3122 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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