(9 nodes) (2022) Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission. network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Predicted Interactions

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Your Input:
	EEA1	Early endosome antigen 1. (1406 aa)
	KIF1A	Kinesin family member 1A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1791 aa)
	LAMP2	Lysosomal associated membrane protein 2. (428 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (116 aa)
	LOC102151505	PH domain-containing protein. (208 aa)
	TH	Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. (495 aa)
	APP	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
	LAMP1	Lysosomal associated membrane protein 1. (413 aa)
	PXDN	Peroxidasin. (1359 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	LAMP1	ENSCAFP00000012583	ENSCAFP00000009494	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Lysosomal associated membrane protein 1.	0.508
APP	PXDN	ENSCAFP00000012583	ENSCAFP00000004792	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Peroxidasin.	0.569
EEA1	LAMP1	ENSCAFP00000009251	ENSCAFP00000009494	Early endosome antigen 1.	Lysosomal associated membrane protein 1.	0.998
EEA1	LAMP2	ENSCAFP00000009251	ENSCAFP00000043773	Early endosome antigen 1.	Lysosomal associated membrane protein 2.	0.972
EEA1	PXDN	ENSCAFP00000009251	ENSCAFP00000004792	Early endosome antigen 1.	Peroxidasin.	0.691
LAMP1	APP	ENSCAFP00000009494	ENSCAFP00000012583	Lysosomal associated membrane protein 1.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.508
LAMP1	EEA1	ENSCAFP00000009494	ENSCAFP00000009251	Lysosomal associated membrane protein 1.	Early endosome antigen 1.	0.998
LAMP1	LAMP2	ENSCAFP00000009494	ENSCAFP00000043773	Lysosomal associated membrane protein 1.	Lysosomal associated membrane protein 2.	0.970
LAMP1	PXDN	ENSCAFP00000009494	ENSCAFP00000004792	Lysosomal associated membrane protein 1.	Peroxidasin.	0.611
LAMP2	EEA1	ENSCAFP00000043773	ENSCAFP00000009251	Lysosomal associated membrane protein 2.	Early endosome antigen 1.	0.972
LAMP2	LAMP1	ENSCAFP00000043773	ENSCAFP00000009494	Lysosomal associated membrane protein 2.	Lysosomal associated membrane protein 1.	0.970
LAMP2	PXDN	ENSCAFP00000043773	ENSCAFP00000004792	Lysosomal associated membrane protein 2.	Peroxidasin.	0.459
PXDN	APP	ENSCAFP00000004792	ENSCAFP00000012583	Peroxidasin.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.569
PXDN	EEA1	ENSCAFP00000004792	ENSCAFP00000009251	Peroxidasin.	Early endosome antigen 1.	0.691
PXDN	LAMP1	ENSCAFP00000004792	ENSCAFP00000009494	Peroxidasin.	Lysosomal associated membrane protein 1.	0.611
PXDN	LAMP2	ENSCAFP00000004792	ENSCAFP00000043773	Peroxidasin.	Lysosomal associated membrane protein 2.	0.459
PXDN	TH	ENSCAFP00000004792	ENSCAFP00000014845	Peroxidasin.	Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.	0.695
TH	PXDN	ENSCAFP00000014845	ENSCAFP00000004792	Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.	Peroxidasin.	0.695