(36 nodes) (2022) Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents. network (Canis lupus familiaris)

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Your Input:
	ACTA2	Actin alpha 2, smooth muscle. (421 aa)
	PLP1	Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. (320 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (513 aa)
	NOTCH4	Notch receptor 4. (1773 aa)
	SOX10	SRY-box transcription factor 10. (468 aa)
	NEUROG1	Neurogenin 1. (246 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	FEZF2	FEZ family zinc finger 2. (470 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (218 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
	HEY1	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] (276 aa)
	MEIS2	Meis homeobox 2. (496 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (732 aa)
	NOTCH2	Notch receptor 2. (2726 aa)
	GAP43	Growth associated protein 43. (291 aa)
	FOXN4	Forkhead box N4. (523 aa)
	S100B	Protein S100; Belongs to the S-100 family. (92 aa)
	MPZ	Myelin protein zero. (332 aa)
	CCR2	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	NOTCH3	Notch receptor 3. (2148 aa)
	NUMB	NUMB endocytic adaptor protein. (723 aa)
	CD19	CD19 molecule. (611 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (917 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1135 aa)
	AVPR2	Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity). (501 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	NOTCH1	Notch receptor 1. (2565 aa)
	SOX17	SRY-box 17. (418 aa)
	CD3D	CD3d molecule. (194 aa)
	C1QA	Complement C1q A chain. (264 aa)
	TFAP2E	TF_AP-2 domain-containing protein. (504 aa)
	CD3E	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (228 aa)
	CD79A	B-cell antigen receptor complex-associated protein alpha chain; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts wit [...] (284 aa)
	CLEC10A	C-type lectin domain containing 10A. (334 aa)
	CCND1	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	DLL1	ENSCAFP00000010864	ENSCAFP00000006075	Achaete-scute family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.564
ASCL1	FEZF2	ENSCAFP00000010864	ENSCAFP00000010567	Achaete-scute family bHLH transcription factor 1.	FEZ family zinc finger 2.	0.434
ASCL1	FOXN4	ENSCAFP00000010864	ENSCAFP00000016069	Achaete-scute family bHLH transcription factor 1.	Forkhead box N4.	0.602
ASCL1	GAP43	ENSCAFP00000010864	ENSCAFP00000015971	Achaete-scute family bHLH transcription factor 1.	Growth associated protein 43.	0.515
ASCL1	NEUROG1	ENSCAFP00000010864	ENSCAFP00000001517	Achaete-scute family bHLH transcription factor 1.	Neurogenin 1.	0.729
ASCL1	SOX10	ENSCAFP00000010864	ENSCAFP00000002067	Achaete-scute family bHLH transcription factor 1.	SRY-box transcription factor 10.	0.741
AVPR2	GAP43	ENSCAFP00000028678	ENSCAFP00000015971	Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity).	Growth associated protein 43.	0.561
BCL11B	NOTCH1	ENSCAFP00000026270	ENSCAFP00000029073	BAF chromatin remodeling complex subunit BCL11B.	Notch receptor 1.	0.406
C1QA	CCR2	ENSCAFP00000040393	ENSCAFP00000020334	Complement C1q A chain.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.589
C1QA	CD3D	ENSCAFP00000040393	ENSCAFP00000038117	Complement C1q A chain.	CD3d molecule.	0.433
CASP3	CCND1	ENSCAFP00000011475	ENSCAFP00000061968	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	0.840
CASP3	CD19	ENSCAFP00000011475	ENSCAFP00000025493	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	CD19 molecule.	0.530
CASP3	GAP43	ENSCAFP00000011475	ENSCAFP00000015971	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Growth associated protein 43.	0.514
CASP3	NOTCH1	ENSCAFP00000011475	ENSCAFP00000029073	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Notch receptor 1.	0.535
CASP3	SOX10	ENSCAFP00000011475	ENSCAFP00000002067	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	SRY-box transcription factor 10.	0.636
CCND1	CASP3	ENSCAFP00000061968	ENSCAFP00000011475	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.840
CCND1	JAG1	ENSCAFP00000061968	ENSCAFP00000008417	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.649
CCND1	NOTCH1	ENSCAFP00000061968	ENSCAFP00000029073	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	Notch receptor 1.	0.696
CCND1	NOTCH2	ENSCAFP00000061968	ENSCAFP00000015629	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	Notch receptor 2.	0.474
CCND1	NOTCH3	ENSCAFP00000061968	ENSCAFP00000023739	G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...]	Notch receptor 3.	0.466