STRINGSTRING
SLC12A8 SLC12A8 INS INS NMNAT1 NMNAT1 ACE2 ACE2 CD38 CD38 ENSCAFP00000045471 ENSCAFP00000045471 NMNAT2 NMNAT2 NAMPT NAMPT NMNAT3 NMNAT3 IMPDH1 IMPDH1 GOT2 GOT2 GOT1 GOT1 IMPDH2 IMPDH2 SIRT1 SIRT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC12A8Solute carrier family 12 member 8. (699 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa)
NMNAT1Nicotinamide-nucleotide adenylyltransferase. (279 aa)
ACE2Angiotensin-converting enzyme. (804 aa)
CD38CD38 molecule. (361 aa)
ENSCAFP00000045471Aspartate aminotransferase. (402 aa)
NMNAT2Nicotinamide nucleotide adenylyltransferase 2. (333 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (534 aa)
NMNAT3Nicotinamide-nucleotide adenylyltransferase. (293 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (542 aa)
GOT2Aspartate aminotransferase. (430 aa)
GOT1Aspartate aminotransferase. (413 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
SIRT1Sirtuin 1. (745 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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