STRINGSTRING
B9D2 B9D2 ATG12 ATG12 HSPA1 HSPA1 EP300 EP300 ATF4 ATF4 LEP LEP CALM2 CALM2 IL15 IL15 TRPV5 TRPV5 ATG5 ATG5 FOXO3 FOXO3 F1PIN6_CANLF F1PIN6_CANLF CALML5 CALML5 METTL3 METTL3 FOXO1 FOXO1 PIK3R4 PIK3R4 LAMP1 LAMP1 SIRT3 SIRT3 ULK1 ULK1 IL1B IL1B APPL1 APPL1 EIF2A EIF2A ADAMTS5 ADAMTS5 FBXO21 FBXO21 ATG3 ATG3 TXNIP TXNIP ADAMTS4 ADAMTS4 ATG4B ATG4B SIRT1 SIRT1 PRG4 PRG4 MMP13 MMP13 ATG14 ATG14 MMP3 MMP3 CALML4 CALML4 PIK3C3 PIK3C3 ATG2B ATG2B TRAF3 TRAF3 UHRF1 UHRF1 CALML6 CALML6 MLST8 MLST8 TSC2 TSC2 IL18 IL18 SIRT6 SIRT6 SOD2 SOD2 LAMP2 LAMP2 ADIPOR2 ADIPOR2 BECN1 BECN1 HDAC6 HDAC6 RHEB RHEB STAT3 STAT3 LOXL3 LOXL3 IL6 IL6 PPARA PPARA ATG4A ATG4A ATG7 ATG7 IGF1 IGF1 TIMP1 TIMP1 CCL5 CCL5 TP53 TP53 TFEB TFEB ACAN ACAN SQSTM1 SQSTM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
HSPA1Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] (699 aa)
EP300E1A binding protein p300. (2308 aa)
ATF4Activating transcription factor 4. (350 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (340 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
FOXO3Forkhead box O3. (671 aa)
F1PIN6_CANLFUncharacterized protein; Belongs to the calmodulin family. (364 aa)
CALML5Calmodulin like 5. (169 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
FOXO1Forkhead box O1. (654 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
LAMP1Lysosomal associated membrane protein 1. (413 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (372 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1004 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
EIF2AEukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (585 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (845 aa)
FBXO21F-box protein 21. (627 aa)
ATG3Autophagy-related protein 3. (312 aa)
TXNIPThioredoxin interacting protein. (391 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif 4. (992 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (389 aa)
SIRT1Sirtuin 1. (745 aa)
PRG4Proteoglycan 4. (767 aa)
MMP13Matrix metallopeptidase 13. (496 aa)
ATG14Autophagy related 14. (510 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family. (478 aa)
CALML4Calmodulin like 4. (120 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
ATG2BAutophagy related 2B. (2077 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (792 aa)
CALML6Calmodulin like 6. (156 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
TSC2TSC complex subunit 2. (1783 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (205 aa)
SIRT6Sirtuin 6. (403 aa)
SOD2Superoxide dismutase [Mn], mitochondrial. (570 aa)
LAMP2Lysosomal associated membrane protein 2. (428 aa)
ADIPOR2Adiponectin receptor 2. (559 aa)
BECN1Beclin 1. (471 aa)
HDAC6Histone deacetylase 6. (1186 aa)
RHEBRas homolog, mTORC1 binding. (232 aa)
STAT3Signal transducer and activator of transcription. (793 aa)
LOXL3Lysyl oxidase like 3. (834 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa)
PPARAPeroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] (568 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (460 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (726 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
TIMP1Metalloproteinase inhibitor 1. (359 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (144 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)
TFEBTranscription factor EB. (566 aa)
ACANAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2332 aa)
SQSTM1Sequestosome 1. (551 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.