(11 nodes) (2023) When Size Really Matters: The Eccentricities of Dystrophin Transcription and the Hazards of Quantifying mRNA from Very Long Genes. network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	PTPRD	Protein tyrosine phosphatase receptor type D. (1923 aa)
	NRXN1	Neurexin 1. (1507 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
	TTN	Titin. (27097 aa)
	NRXN3	Neurexin 3. (1650 aa)
	MYH4	Myosin-4; Muscle contraction. (1939 aa)
	MYH2	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). (1940 aa)
	MYH1	Myosin-1; Muscle contraction. (1953 aa)
	SSPN	Sarcospan. (226 aa)
	DAG1	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (892 aa)
	CNTNAP2	Contactin associated protein like 2. (1331 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAG1	NRXN1	ENSCAFP00000016488	ENSCAFP00000051642	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	Neurexin 1.	0.693
DAG1	NRXN3	ENSCAFP00000016488	ENSCAFP00000036750	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	Neurexin 3.	0.706
DAG1	SSPN	ENSCAFP00000016488	ENSCAFP00000016763	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	Sarcospan.	0.970
MYH1	MYH2	ENSCAFP00000025847	ENSCAFP00000025869	Myosin-1; Muscle contraction.	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity).	0.644
MYH1	MYH4	ENSCAFP00000025847	ENSCAFP00000025934	Myosin-1; Muscle contraction.	Myosin-4; Muscle contraction.	0.573
MYH1	TTN	ENSCAFP00000025847	ENSCAFP00000045361	Myosin-1; Muscle contraction.	Titin.	0.598
MYH2	MYH1	ENSCAFP00000025869	ENSCAFP00000025847	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity).	Myosin-1; Muscle contraction.	0.644
MYH2	MYH4	ENSCAFP00000025869	ENSCAFP00000025934	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity).	Myosin-4; Muscle contraction.	0.556
MYH2	TTN	ENSCAFP00000025869	ENSCAFP00000045361	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity).	Titin.	0.530
MYH4	MYH1	ENSCAFP00000025934	ENSCAFP00000025847	Myosin-4; Muscle contraction.	Myosin-1; Muscle contraction.	0.573
MYH4	MYH2	ENSCAFP00000025934	ENSCAFP00000025869	Myosin-4; Muscle contraction.	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity).	0.556
NRXN1	DAG1	ENSCAFP00000051642	ENSCAFP00000016488	Neurexin 1.	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	0.693
NRXN1	NRXN3	ENSCAFP00000051642	ENSCAFP00000036750	Neurexin 1.	Neurexin 3.	0.903
NRXN3	DAG1	ENSCAFP00000036750	ENSCAFP00000016488	Neurexin 3.	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	0.706
NRXN3	NRXN1	ENSCAFP00000036750	ENSCAFP00000051642	Neurexin 3.	Neurexin 1.	0.903
NRXN3	SSPN	ENSCAFP00000036750	ENSCAFP00000016763	Neurexin 3.	Sarcospan.	0.427
SSPN	DAG1	ENSCAFP00000016763	ENSCAFP00000016488	Sarcospan.	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	0.970
SSPN	NRXN3	ENSCAFP00000016763	ENSCAFP00000036750	Sarcospan.	Neurexin 3.	0.427
TTN	MYH1	ENSCAFP00000045361	ENSCAFP00000025847	Titin.	Myosin-1; Muscle contraction.	0.598
TTN	MYH2	ENSCAFP00000045361	ENSCAFP00000025869	Titin.	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity).	0.530