(26 nodes) Zinc-dependent metalloprotease network (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MMP20	Matrix metallopeptidase 20. (483 aa)
	MMP12	ZnMc domain-containing protein. (491 aa)
	MMP7	Matrix metallopeptidase 7. (263 aa)
	MMP25	Matrix metallopeptidase 25. (560 aa)
	MMP23	Matrix metallopeptidase 23. (391 aa)
	MMP28	Matrix metallopeptidase 28. (520 aa)
	MEP1B	Meprin A subunit. (703 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	MMP27	Matrix metallopeptidase 27. (512 aa)
	MMP11	Matrix metallopeptidase 11. (489 aa)
	MMP21	Matrix metallopeptidase 21. (658 aa)
	TLL1	Metalloendopeptidase. (1031 aa)
	BMP1	Metalloendopeptidase. (988 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	MMP26	Matrix metallopeptidase 26. (285 aa)
	MMP13	Matrix metallopeptidase 13. (496 aa)
	MMP8	Matrix metallopeptidase 8. (476 aa)
	MMP3	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family. (478 aa)
	MMP19	Matrix metallopeptidase 19. (547 aa)
	MEP1A	Meprin A subunit. (748 aa)
	MMP17	Matrix metallopeptidase 17. (516 aa)
	MMP24	Matrix metallopeptidase 24. (616 aa)
	MMP15	Matrix metallopeptidase 15. (618 aa)
	TLL2	Metalloendopeptidase. (1021 aa)
	ASTL	Metalloendopeptidase. (450 aa)
	MMP1	Matrix metallopeptidase 1. (465 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP1	MMP1	ENSCAFP00000046623	ENSCAFP00000038708	Metalloendopeptidase.	Matrix metallopeptidase 1.	0.499
BMP1	TLL1	ENSCAFP00000046623	ENSCAFP00000051087	Metalloendopeptidase.	Metalloendopeptidase.	0.416
BMP1	TLL2	ENSCAFP00000046623	ENSCAFP00000012707	Metalloendopeptidase.	Metalloendopeptidase.	0.425
MEP1A	MEP1B	ENSCAFP00000003016	ENSCAFP00000026614	Meprin A subunit.	Meprin A subunit.	0.919
MEP1B	MEP1A	ENSCAFP00000026614	ENSCAFP00000003016	Meprin A subunit.	Meprin A subunit.	0.919
MMP1	BMP1	ENSCAFP00000038708	ENSCAFP00000046623	Matrix metallopeptidase 1.	Metalloendopeptidase.	0.499
MMP1	MMP11	ENSCAFP00000038708	ENSCAFP00000055831	Matrix metallopeptidase 1.	Matrix metallopeptidase 11.	0.655
MMP1	MMP12	ENSCAFP00000038708	ENSCAFP00000031802	Matrix metallopeptidase 1.	ZnMc domain-containing protein.	0.443
MMP1	MMP13	ENSCAFP00000038708	ENSCAFP00000022174	Matrix metallopeptidase 1.	Matrix metallopeptidase 13.	0.698
MMP1	MMP3	ENSCAFP00000038708	ENSCAFP00000022195	Matrix metallopeptidase 1.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.	0.950
MMP1	MMP7	ENSCAFP00000038708	ENSCAFP00000030464	Matrix metallopeptidase 1.	Matrix metallopeptidase 7.	0.675
MMP11	MMP1	ENSCAFP00000055831	ENSCAFP00000038708	Matrix metallopeptidase 11.	Matrix metallopeptidase 1.	0.655
MMP11	MMP19	ENSCAFP00000055831	ENSCAFP00000000111	Matrix metallopeptidase 11.	Matrix metallopeptidase 19.	0.442
MMP11	MMP7	ENSCAFP00000055831	ENSCAFP00000030464	Matrix metallopeptidase 11.	Matrix metallopeptidase 7.	0.594
MMP12	MMP1	ENSCAFP00000031802	ENSCAFP00000038708	ZnMc domain-containing protein.	Matrix metallopeptidase 1.	0.443
MMP13	MMP1	ENSCAFP00000022174	ENSCAFP00000038708	Matrix metallopeptidase 13.	Matrix metallopeptidase 1.	0.698
MMP13	MMP14	ENSCAFP00000022174	ENSCAFP00000016472	Matrix metallopeptidase 13.	Matrix metallopeptidase 14.	0.815
MMP13	MMP16	ENSCAFP00000022174	ENSCAFP00000013128	Matrix metallopeptidase 13.	Matrix metallopeptidase 16.	0.796
MMP13	MMP3	ENSCAFP00000022174	ENSCAFP00000022195	Matrix metallopeptidase 13.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.	0.703
MMP13	MMP7	ENSCAFP00000022174	ENSCAFP00000030464	Matrix metallopeptidase 13.	Matrix metallopeptidase 7.	0.625