STRINGSTRING
ADGRA3 ADGRA3 RXFP2 RXFP2 TLR3 TLR3 TLR7 TLR7 LRRN2 LRRN2 CPN2 CPN2 LRRTM3 LRRTM3 RTN4RL2 RTN4RL2 LRRC3 LRRC3 LRIG2 LRIG2 NYX NYX SLITRK1 SLITRK1 LOC491436 LOC491436 RTN4RL1 RTN4RL1 SLITRK2 SLITRK2 LRRTM2 LRRTM2 LINGO2 LINGO2 ADGRA2 ADGRA2 LRFN5 LRFN5 LRRC15 LRRC15 LRRN4 LRRN4 FLRT3 FLRT3 LRRC66 LRRC66 LRRC3C LRRC3C TPBGL TPBGL LRRC30 LRRC30 RXFP1 RXFP1 VASN VASN TLR9-2 TLR9-2 LRRK1 LRRK1 LRRC40 LRRC40 LRRC8C LRRC8C LRRC8D LRRC8D AP1G1 AP1G1 LRRC8A LRRC8A LRRC39 LRRC39 LRRC26 LRRC26 IGFALS IGFALS LRRC47 LRRC47 PODN PODN SLITRK4 SLITRK4 LRG1 LRG1 OMG OMG LRRC8E LRRC8E LRCH2 LRCH2 ISLR ISLR ISLR2 ISLR2 FLRT2 FLRT2 CHAD CHAD PODNL1 PODNL1 LGI2 LGI2 LRTM2 LRTM2 LRIT2 LRIT2 LRRIQ4 LRRIQ4 FLRT1 FLRT1 SLITRK3 SLITRK3 LRR1 LRR1 LRRC2 LRRC2 PIGX PIGX LINGO4 LINGO4 LRFN4 LRFN4 LRIT3 LRIT3 TLR5 TLR5 AMIGO3 AMIGO3 MXRA5 MXRA5 LRRC58 LRRC58 LRRC27 LRRC27 LRRC57 LRRC57 SHOC2 SHOC2 LRRC28 LRRC28 LGR6 LGR6 LRRK2 LRRK2 LGI3 LGI3 OPTC OPTC FMOD FMOD AMIGO2 AMIGO2 SLIT1 SLIT1 IGSF10 IGSF10 TLR2 TLR2 LRTM1 LRTM1 LRRTM1 LRRTM1 LGI1 LGI1 LGI4 LGI4 LRRC4C LRRC4C PXDNL PXDNL MFHAS1 MFHAS1 LRIG1 LRIG1 DCN DCN LUM LUM LRRN1 LRRN1 LRRC3B LRRC3B LRFN1 LRFN1 SLITRK5 SLITRK5 LRRC32 LRRC32 RSU1 RSU1 LRCH1 LRCH1 LRRN3 LRRN3 PXDN PXDN TRIL TRIL LRRC4B LRRC4B LRRD1 LRRD1 LRRC4 LRRC4 CHADL CHADL CNOT6 CNOT6 LRWD1 LRWD1 LRRC8B LRRC8B SLIT2 SLIT2 TPBG TPBG LGR4 LGR4 SLITRK6 SLITRK6 LGR5 LGR5 PIDD1 PIDD1 LRRTM4 LRRTM4 RTN4R RTN4R LINGO1 LINGO1 LOC102156225 LOC102156225 LRIG3 LRIG3 LRFN2 LRFN2 SCRIB SCRIB SLIT3 SLIT3 LRRC24 LRRC24 CNTRL CNTRL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADGRA3Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family. (1249 aa)
RXFP2Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family. (737 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1121 aa)
LRRN2Leucine rich repeat neuronal 2. (712 aa)
CPN2Carboxypeptidase N subunit 2. (547 aa)
LRRTM3Leucine rich repeat transmembrane neuronal 3. (581 aa)
RTN4RL2Reticulon 4 receptor like 2. (186 aa)
LRRC3Leucine rich repeat containing 3. (257 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1069 aa)
NYXNyctalopin. (474 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
LOC491436Uncharacterized protein. (1430 aa)
RTN4RL1Reticulon 4 receptor like 1. (445 aa)
SLITRK2SLIT and NTRK like family member 2. (845 aa)
LRRTM2Leucine rich repeat transmembrane neuronal 2. (516 aa)
LINGO2Leucine rich repeat and Ig domain containing 2. (606 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1319 aa)
LRFN5Leucine rich repeat and fibronectin type III domain containing 5. (722 aa)
LRRC15Leucine rich repeat containing 15. (608 aa)
LRRN4Leucine rich repeat neuronal 4. (665 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
LRRC66Leucine rich repeat containing 66. (977 aa)
LRRC3CLeucine rich repeat containing 3C. (273 aa)
TPBGLTrophoblast glycoprotein like. (392 aa)
LRRC30Leucine rich repeat containing 30. (301 aa)
RXFP1Relaxin family peptide receptor 1. (679 aa)
VASNVasorin. (672 aa)
TLR9-2Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
LRRK1Leucine rich repeat kinase 1. (2014 aa)
LRRC40Leucine rich repeat containing 40. (552 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit C. (803 aa)
LRRC8DLeucine rich repeat containing 8 VRAC subunit D. (858 aa)
AP1G1PH domain and leucine rich repeat protein phosphatase 2. (1351 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
LRRC39Leucine rich repeat containing 39. (335 aa)
LRRC26Leucine rich repeat containing 26. (316 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (654 aa)
LRRC47Leucine rich repeat containing 47. (589 aa)
PODNPodocan. (598 aa)
SLITRK4SLIT and NTRK like family member 4. (838 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
OMGOligodendrocyte myelin glycoprotein. (440 aa)
LRRC8ELeucine rich repeat containing 8 VRAC subunit E. (793 aa)
LRCH2Leucine rich repeats and calponin homology domain containing 2. (816 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (462 aa)
ISLR2Immunoglobulin superfamily containing leucine rich repeat 2. (702 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
CHADChondroadherin. (359 aa)
PODNL1Podocan like 1. (575 aa)
LGI2Leucine rich repeat LGI family member 2. (524 aa)
LRTM2Leucine rich repeats and transmembrane domains 2. (370 aa)
LRIT2Leucine rich repeat, Ig-like and transmembrane domains 2. (550 aa)
LRRIQ4Leucine rich repeats and IQ motif containing 4. (559 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (695 aa)
SLITRK3SLIT and NTRK like family member 3. (979 aa)
LRR1Leucine rich repeat protein 1. (422 aa)
LRRC2Leucine rich repeat containing 2. (371 aa)
PIGXPhosphatidylinositol glycan anchor biosynthesis class X. (697 aa)
LINGO4Leucine rich repeat and Ig domain containing 4. (649 aa)
LRFN4Leucine rich repeat and fibronectin type III domain containing 4. (636 aa)
LRIT3Leucine rich repeat, Ig-like and transmembrane domains 3. (681 aa)
TLR5TIR domain-containing protein; Belongs to the Toll-like receptor family. (1093 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (508 aa)
MXRA5Matrix remodeling associated 5. (2833 aa)
LRRC58Leucine rich repeat containing 58. (565 aa)
LRRC27Leucine rich repeat containing 27. (533 aa)
LRRC57Uncharacterized protein. (239 aa)
SHOC2SHOC2 leucine rich repeat scaffold protein. (582 aa)
LRRC28Leucine rich repeat containing 28. (367 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (965 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
LGI3Leucine rich repeat LGI family member 3. (548 aa)
OPTCOpticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). (327 aa)
FMODFibromodulin. (376 aa)
AMIGO2Adhesion molecule with Ig like domain 2. (521 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
IGSF10Immunoglobulin superfamily member 10. (2629 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa)
LRTM1Leucine rich repeats and transmembrane domains 1. (345 aa)
LRRTM1Leucine rich repeat transmembrane neuronal 1. (522 aa)
LGI1Leucine rich glioma inactivated 1. (557 aa)
LGI4Leucine rich repeat LGI family member 4. (534 aa)
LRRC4CLeucine rich repeat containing 4C. (639 aa)
PXDNLPeroxidasin like. (1468 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1042 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1042 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
LUMLumican. (338 aa)
LRRN1Leucine rich repeat neuronal 1. (716 aa)
LRRC3BLeucine rich repeat containing 3B. (259 aa)
LRFN1Leucine rich repeat and fibronectin type III domain containing 1. (770 aa)
SLITRK5SLIT and NTRK like family member 5. (958 aa)
LRRC32Leucine rich repeat containing 32. (661 aa)
RSU1Ras suppressor protein 1. (277 aa)
LRCH1Leucine rich repeats and calponin homology domain containing 1. (735 aa)
LRRN3Leucine rich repeat neuronal 3. (708 aa)
PXDNPeroxidasin. (1359 aa)
TRILTLR4 interactor with leucine rich repeats. (825 aa)
LRRC4BLeucine rich repeat containing 4B. (717 aa)
LRRD1Leucine rich repeats and death domain containing 1. (875 aa)
LRRC4Leucine rich repeat containing 4. (650 aa)
CHADLRan GTPase activating protein 1. (738 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (592 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (716 aa)
LRRC8BLeucine rich repeat containing 8 VRAC subunit B. (839 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
TPBGTrophoblast glycoprotein. (610 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (1040 aa)
SLITRK6SLIT and NTRK like family member 6. (877 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (877 aa)
PIDD1P53-induced death domain protein 1. (948 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (590 aa)
RTN4RReticulon 4 receptor. (463 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (768 aa)
LOC102156225Uncharacterized protein. (649 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1086 aa)
LRFN2Leucine rich repeat and fibronectin type III domain containing 2. (832 aa)
SCRIBScribble planar cell polarity protein. (1568 aa)
SLIT3Slit guidance ligand 3. (1487 aa)
LRRC24Leucine rich repeat containing 24. (636 aa)
CNTRLCentriolin. (2506 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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