STRINGSTRING
TLR1 TLR1 SLITRK6 SLITRK6 LGR5 LGR5 PIDD1 PIDD1 LRRTM4 LRRTM4 RTN4R RTN4R LINGO1 LINGO1 ERBIN ERBIN LOC102156225 LOC102156225 LRIG3 LRIG3 FBXL14 FBXL14 FLII FLII CEP78 CEP78 KDM2B KDM2B LRWD1 LRWD1 LRRC8B LRRC8B SLIT2 SLIT2 PPP1R7 PPP1R7 CIITA CIITA LRSAM1 LRSAM1 TPBG TPBG ENSCAFP00000055743 ENSCAFP00000055743 FBXL20 FBXL20 LGR4 LGR4 PRELP PRELP LRFN5 LRFN5 LRRC49 LRRC49 LRFN2 LRFN2 SCRIB SCRIB FBXL17 FBXL17 SLIT3 SLIT3 LRRC24 LRRC24 CNTRL CNTRL NLRP14 NLRP14 ORAI3 ORAI3 FBXL2 FBXL2 STK11IP STK11IP LRRC34 LRRC34 NLRC5 NLRC5 RXFP2 RXFP2 TLR3 TLR3 LRRC74A LRRC74A ELFN2 ELFN2 CARMIL1 CARMIL1 TLR7 TLR7 LRRN2 LRRN2 CPN2 CPN2 LRRC20 LRRC20 LRRC46 LRRC46 NLRP12 NLRP12 LRRC29 LRRC29 LRRC9 LRRC9 LRRTM3 LRRTM3 RTN4RL2 RTN4RL2 LRRC3 LRRC3 LOC102157101 LOC102157101 LRRC45 LRRC45 LRIG2 LRIG2 NYX NYX LRRC63 LRRC63 LRRC38 LRRC38 LRRC55 LRRC55 FBXL7 FBXL7 LOC477430 LOC477430 SLITRK1 SLITRK1 LOC100855742 LOC100855742 LOC491436 LOC491436 RTN4RL1 RTN4RL1 LRRC1 LRRC1 SLITRK2 SLITRK2 LRRC7 LRRC7 LRRTM2 LRRTM2 LINGO2 LINGO2 ADGRA2 ADGRA2 CARMIL2 CARMIL2 LRRC10B LRRC10B LRRC15 LRRC15 LRRN4 LRRN4 FLRT3 FLRT3 RNH1 RNH1 LRRC73 LRRC73 LRRC66 LRRC66 LRRC3C LRRC3C TPBGL TPBGL LRRC30 LRRC30 ASPN ASPN RXFP1 RXFP1 VASN VASN TLR4 TLR4 TLR9-2 TLR9-2 LRRK1 LRRK1 LRRC74B LRRC74B LRRC40 LRRC40 LRRC8C LRRC8C LRRC8D LRRC8D AP1G1 AP1G1 LRRC8A LRRC8A LRRC39 LRRC39 FBXL16 FBXL16 LRRC26 LRRC26 IGFALS IGFALS LRRC47 LRRC47 BGN BGN PHLPP1 PHLPP1 LRRC10 LRRC10 CNOT6 CNOT6 NEPN NEPN CHADL CHADL TONSL TONSL LRRC19 LRRC19 LRRC4 LRRC4 LRRD1 LRRD1 TCTE1 TCTE1 ECM2 ECM2 OMD OMD OGN OGN NLRP5 NLRP5 NLRP8 NLRP8 NLRP9 NLRP9 NLRP13 NLRP13 NLRP2 NLRP2 LRRC4B LRRC4B TRIL TRIL NOD1 NOD1 PXDN PXDN LRRN3 LRRN3 FBXL4 FBXL4 FBXL13 FBXL13 LRRC17 LRRC17 LRCH1 LRCH1 PPP1R37 PPP1R37 RSU1 RSU1 TSKU TSKU LRRC32 LRRC32 SLITRK5 SLITRK5 XRRA1 XRRA1 LRFN1 LRFN1 LRRC3B LRRC3B LRRN1 LRRN1 EPYC EPYC KERA KERA LUM LUM DCN DCN LRRC18 LRRC18 LRIG1 LRIG1 MFHAS1 MFHAS1 PXDNL PXDNL LRRC4C LRRC4C LGI4 LGI4 CD180 CD180 LGI1 LGI1 LRRTM1 LRRTM1 LRTM1 LRTM1 TLR2 TLR2 IGSF10 IGSF10 LRRCC1 LRRCC1 CNOT6L CNOT6L SLIT1 SLIT1 LRRC69 LRRC69 AMIGO2 AMIGO2 NISCH NISCH FMOD FMOD OPTC OPTC LGI3 LGI3 NOD2 NOD2 LRRK2 LRRK2 FBXL15 FBXL15 LGR6 LGR6 NLRP3 NLRP3 LRRC28 LRRC28 SHOC2 SHOC2 CEP72 CEP72 LRRC57 LRRC57 LRRC27 LRRC27 LRRC58 LRRC58 MXRA5 MXRA5 AMIGO3 AMIGO3 TLR5 TLR5 LRIT3 LRIT3 KDM2A KDM2A LRFN4 LRFN4 NLRX1 NLRX1 RABGGTA RABGGTA LRCH3 LRCH3 LINGO4 LINGO4 PIGX PIGX LRRC52 LRRC52 LRRC2 LRRC2 LRR1 LRR1 SLITRK3 SLITRK3 LRRC23 LRRC23 FLRT1 FLRT1 LRRIQ4 LRRIQ4 LRRC31 LRRC31 FBXL5 FBXL5 NLRP1 NLRP1 LRIT2 LRIT2 LRTM2 LRTM2 TLR6 TLR6 TLR10 TLR10 LRRC71 LRRC71 PODNL1 PODNL1 FBXL22 FBXL22 LRRC59 LRRC59 CHAD CHAD FLRT2 FLRT2 ISLR2 ISLR2 ISLR ISLR LRCH2 LRCH2 LRRC8E LRRC8E OMG OMG SKP2 SKP2 LRG1 LRG1 SLITRK4 SLITRK4 PODN PODN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (760 aa)
SLITRK6SLIT and NTRK like family member 6. (877 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (877 aa)
PIDD1P53-induced death domain protein 1. (948 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (590 aa)
RTN4RReticulon 4 receptor. (463 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (768 aa)
ERBINErbb2 interacting protein. (1460 aa)
LOC102156225Uncharacterized protein. (649 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1086 aa)
FBXL14F-box and leucine rich repeat protein 14. (428 aa)
FLIIFLII actin remodeling protein. (1409 aa)
CEP78Centrosomal protein 78. (728 aa)
KDM2BLysine demethylase 2B. (1397 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (716 aa)
LRRC8BLeucine rich repeat containing 8 VRAC subunit B. (839 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
PPP1R7Protein phosphatase 1 regulatory subunit 7. (549 aa)
CIITAClass II major histocompatibility complex transactivator. (1206 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (743 aa)
TPBGTrophoblast glycoprotein. (610 aa)
ENSCAFP00000055743Uncharacterized protein. (305 aa)
FBXL20F-box and leucine rich repeat protein 20. (444 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (1040 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (404 aa)
LRFN5Leucine rich repeat and fibronectin type III domain containing 5. (722 aa)
LRRC49Leucine rich repeat containing 49. (762 aa)
LRFN2Leucine rich repeat and fibronectin type III domain containing 2. (832 aa)
SCRIBScribble planar cell polarity protein. (1568 aa)
FBXL17F-box and leucine rich repeat protein 17. (308 aa)
SLIT3Slit guidance ligand 3. (1487 aa)
LRRC24Leucine rich repeat containing 24. (636 aa)
CNTRLCentriolin. (2506 aa)
NLRP14NLR family pyrin domain containing 14. (1092 aa)
ORAI3F-box and leucine rich repeat protein 19. (696 aa)
FBXL2F-box and leucine rich repeat protein 2. (466 aa)
STK11IPSerine/threonine kinase 11 interacting protein. (1173 aa)
LRRC34Leucine rich repeat containing 34. (493 aa)
NLRC5NLR family CARD domain containing 5. (1859 aa)
RXFP2Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family. (737 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa)
LRRC74ALeucine rich repeat containing 74A. (488 aa)
ELFN2Extracellular leucine rich repeat and fibronectin type III domain containing 2. (696 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1433 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1121 aa)
LRRN2Leucine rich repeat neuronal 2. (712 aa)
CPN2Carboxypeptidase N subunit 2. (547 aa)
LRRC20Leucine rich repeat containing 20. (184 aa)
LRRC46Leucine rich repeat containing 46. (322 aa)
NLRP12Uncharacterized protein. (1059 aa)
LRRC29Leucine rich repeat containing 29. (223 aa)
LRRC9Leucine rich repeat containing 9. (1492 aa)
LRRTM3Leucine rich repeat transmembrane neuronal 3. (581 aa)
RTN4RL2Reticulon 4 receptor like 2. (186 aa)
LRRC3Leucine rich repeat containing 3. (257 aa)
LOC102157101NACHT domain-containing protein. (1050 aa)
LRRC45Leucine rich repeat containing 45. (644 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1069 aa)
NYXNyctalopin. (474 aa)
LRRC63Leucine rich repeat containing 63. (580 aa)
LRRC38Leucine rich repeat containing 38. (211 aa)
LRRC55Leucine rich repeat containing 55. (318 aa)
FBXL7F-box and leucine rich repeat protein 7. (475 aa)
LOC477430Uncharacterized protein. (545 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
LOC100855742Uncharacterized protein. (1062 aa)
LOC491436Uncharacterized protein. (1430 aa)
RTN4RL1Reticulon 4 receptor like 1. (445 aa)
LRRC1Leucine rich repeat containing 1. (511 aa)
SLITRK2SLIT and NTRK like family member 2. (845 aa)
LRRC7Leucine rich repeat containing 7. (1574 aa)
LRRTM2Leucine rich repeat transmembrane neuronal 2. (516 aa)
LINGO2Leucine rich repeat and Ig domain containing 2. (606 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1319 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1181 aa)
LRRC10BLeucine rich repeat containing 10B. (292 aa)
LRRC15Leucine rich repeat containing 15. (608 aa)
LRRN4Leucine rich repeat neuronal 4. (665 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
RNH1Ribonuclease/angiogenin inhibitor 1. (262 aa)
LRRC73Leucine rich repeat containing 73. (292 aa)
LRRC66Leucine rich repeat containing 66. (977 aa)
LRRC3CLeucine rich repeat containing 3C. (273 aa)
TPBGLTrophoblast glycoprotein like. (392 aa)
LRRC30Leucine rich repeat containing 30. (301 aa)
ASPNAsporin. (372 aa)
RXFP1Relaxin family peptide receptor 1. (679 aa)
VASNVasorin. (672 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
TLR9-2Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
LRRK1Leucine rich repeat kinase 1. (2014 aa)
LRRC74BLeucine rich repeat containing 74B. (392 aa)
LRRC40Leucine rich repeat containing 40. (552 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit C. (803 aa)
LRRC8DLeucine rich repeat containing 8 VRAC subunit D. (858 aa)
AP1G1PH domain and leucine rich repeat protein phosphatase 2. (1351 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
LRRC39Leucine rich repeat containing 39. (335 aa)
FBXL16F-box and leucine rich repeat protein 16. (483 aa)
LRRC26Leucine rich repeat containing 26. (316 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (654 aa)
LRRC47Leucine rich repeat containing 47. (589 aa)
BGNBiglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (417 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1433 aa)
LRRC10Leucine rich repeat containing 10. (279 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (592 aa)
NEPNUncharacterized protein. (512 aa)
CHADLRan GTPase activating protein 1. (738 aa)
TONSLTonsoku like, DNA repair protein. (1354 aa)
LRRC19Leucine rich repeat containing 19. (369 aa)
LRRC4Leucine rich repeat containing 4. (650 aa)
LRRD1Leucine rich repeats and death domain containing 1. (875 aa)
TCTE1T-complex-associated-testis-expressed 1. (501 aa)
ECM2Extracellular matrix protein 2. (700 aa)
OMDOsteomodulin. (414 aa)
OGNOsteoglycin. (297 aa)
NLRP5NLR family pyrin domain containing 5. (1142 aa)
NLRP8NLR family pyrin domain containing 8. (1016 aa)
NLRP9NLR family pyrin domain containing 9. (988 aa)
NLRP13NLR family pyrin domain containing 13. (1063 aa)
NLRP2Uncharacterized protein. (162 aa)
LRRC4BLeucine rich repeat containing 4B. (717 aa)
TRILTLR4 interactor with leucine rich repeats. (825 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (964 aa)
PXDNPeroxidasin. (1359 aa)
LRRN3Leucine rich repeat neuronal 3. (708 aa)
FBXL4F-box and leucine rich repeat protein 4. (621 aa)
FBXL13F-box and leucine rich repeat protein 13. (734 aa)
LRRC17Leucine rich repeat containing 17. (463 aa)
LRCH1Leucine rich repeats and calponin homology domain containing 1. (735 aa)
PPP1R37Protein phosphatase 1 regulatory subunit 37. (700 aa)
RSU1Ras suppressor protein 1. (277 aa)
TSKUTsukushi, small leucine rich proteoglycan. (396 aa)
LRRC32Leucine rich repeat containing 32. (661 aa)
SLITRK5SLIT and NTRK like family member 5. (958 aa)
XRRA1X-ray radiation resistance associated 1. (799 aa)
LRFN1Leucine rich repeat and fibronectin type III domain containing 1. (770 aa)
LRRC3BLeucine rich repeat containing 3B. (259 aa)
LRRN1Leucine rich repeat neuronal 1. (716 aa)
EPYCEpiphycan. (320 aa)
KERAKeratocan. (350 aa)
LUMLumican. (338 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
LRRC18Leucine rich repeat containing 18. (261 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1042 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1042 aa)
PXDNLPeroxidasin like. (1468 aa)
LRRC4CLeucine rich repeat containing 4C. (639 aa)
LGI4Leucine rich repeat LGI family member 4. (534 aa)
CD180CD180 molecule. (661 aa)
LGI1Leucine rich glioma inactivated 1. (557 aa)
LRRTM1Leucine rich repeat transmembrane neuronal 1. (522 aa)
LRTM1Leucine rich repeats and transmembrane domains 1. (345 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa)
IGSF10Immunoglobulin superfamily member 10. (2629 aa)
LRRCC1Leucine rich repeat and coiled-coil centrosomal protein 1. (1027 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (558 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
LRRC69Uncharacterized protein. (347 aa)
AMIGO2Adhesion molecule with Ig like domain 2. (521 aa)
NISCHNischarin. (1537 aa)
FMODFibromodulin. (376 aa)
OPTCOpticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). (327 aa)
LGI3Leucine rich repeat LGI family member 3. (548 aa)
NOD2Uncharacterized protein. (1013 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
FBXL15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. (300 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (965 aa)
NLRP3NLR family pyrin domain containing 3. (1065 aa)
LRRC28Leucine rich repeat containing 28. (367 aa)
SHOC2SHOC2 leucine rich repeat scaffold protein. (582 aa)
CEP72Centrosomal protein 72. (626 aa)
LRRC57Uncharacterized protein. (239 aa)
LRRC27Leucine rich repeat containing 27. (533 aa)
LRRC58Leucine rich repeat containing 58. (565 aa)
MXRA5Matrix remodeling associated 5. (2833 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (508 aa)
TLR5TIR domain-containing protein; Belongs to the Toll-like receptor family. (1093 aa)
LRIT3Leucine rich repeat, Ig-like and transmembrane domains 3. (681 aa)
KDM2ALysine demethylase 2A. (1162 aa)
LRFN4Leucine rich repeat and fibronectin type III domain containing 4. (636 aa)
NLRX1NLR family member X1. (975 aa)
RABGGTARab geranylgeranyltransferase subunit alpha. (567 aa)
LRCH3Leucine rich repeats and calponin homology domain containing 3. (793 aa)
LINGO4Leucine rich repeat and Ig domain containing 4. (649 aa)
PIGXPhosphatidylinositol glycan anchor biosynthesis class X. (697 aa)
LRRC52Leucine rich repeat containing 52. (315 aa)
LRRC2Leucine rich repeat containing 2. (371 aa)
LRR1Leucine rich repeat protein 1. (422 aa)
SLITRK3SLIT and NTRK like family member 3. (979 aa)
LRRC23Leucine rich repeat containing 23. (382 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (695 aa)
LRRIQ4Leucine rich repeats and IQ motif containing 4. (559 aa)
LRRC31Leucine rich repeat containing 31. (557 aa)
FBXL5F-box and leucine rich repeat protein 5. (691 aa)
NLRP1NLR family pyrin domain containing 1. (1432 aa)
LRIT2Leucine rich repeat, Ig-like and transmembrane domains 2. (550 aa)
LRTM2Leucine rich repeats and transmembrane domains 2. (370 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (797 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (807 aa)
LRRC71Leucine rich repeat containing 71. (560 aa)
PODNL1Podocan like 1. (575 aa)
FBXL22Uncharacterized protein. (223 aa)
LRRC59Leucine rich repeat containing 59. (305 aa)
CHADChondroadherin. (359 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
ISLR2Immunoglobulin superfamily containing leucine rich repeat 2. (702 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (462 aa)
LRCH2Leucine rich repeats and calponin homology domain containing 2. (816 aa)
LRRC8ELeucine rich repeat containing 8 VRAC subunit E. (793 aa)
OMGOligodendrocyte myelin glycoprotein. (440 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
SLITRK4SLIT and NTRK like family member 4. (838 aa)
PODNPodocan. (598 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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