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| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa) |
| | STAT2 | Signal transducer and activator of transcription. (844 aa) |
| | PTPRR | Protein tyrosine phosphatase receptor type R. (671 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
| | ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1132 aa) |
| | PLEC | Plectin. (4703 aa) |
| | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1. (354 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (653 aa) |
| | NCK2 | Cytoplasmic protein. (380 aa) |
| | EPN1 | Epsin 1. (569 aa) |
| | EEF1A1 | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1141 aa) |
| | GAB1 | GRB2 associated binding protein 1. (701 aa) |
| | EPS15 | Epidermal growth factor receptor pathway substrate 15. (891 aa) |
| | PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1104 aa) |
| | MAP3K2 | Mitogen-activated protein kinase kinase kinase 2. (620 aa) |
| | CBLC | Cbl proto-oncogene C. (497 aa) |
| | GAB2 | GRB2 associated binding protein 2. (663 aa) |
| | RALB | RAS like proto-oncogene B. (206 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (315 aa) |
| | INPPL1 | Inositol polyphosphate phosphatase like 1. (1264 aa) |
| | RAB5A | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa) |
| | FOXO1 | Forkhead box O1. (654 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa) |
| | SP1 | Sp1 transcription factor. (782 aa) |
| | KRT18 | IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa) |
| | KRT86 | IF rod domain-containing protein; Belongs to the intermediate filament family. (495 aa) |
| | KRT7 | IF rod domain-containing protein; Belongs to the intermediate filament family. (135 aa) |
| | NCK1 | Cytoplasmic protein. (377 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (862 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | CTNND1 | Catenin delta 1. (967 aa) |
| | APPL1 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | PTPN5 | Protein tyrosine phosphatase non-receptor type 5. (555 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | NRAS | Uncharacterized protein. (189 aa) |
| | PABPC1L | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (611 aa) |
| | PIK3C2B | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa) |
| | CBLB | Cbl proto-oncogene B. (1004 aa) |
| | DOK2 | Docking protein 2. (412 aa) |
| | SHOC2 | SHOC2 leucine rich repeat scaffold protein. (582 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa) |
| | RPS6KA1 | Non-specific serine/threonine protein kinase. (876 aa) |
| | REPS2 | RALBP1 associated Eps domain containing 2. (654 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa) |
| | TNK2 | Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1092 aa) |
| | SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3. (332 aa) |
| | ZPR1 | ZPR1 zinc finger. (460 aa) |
| | HIP1 | Huntingtin interacting protein 1. (1036 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (955 aa) |
| | NDUFA13 | NADH:ubiquinone oxidoreductase subunit A13. (144 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa) |
| | RFXANK | Regulatory factor X associated ankyrin containing protein. (260 aa) |
| | HTT | Huntingtin. (3130 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa) |
| | PIK3R2 | Uncharacterized protein. (726 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (605 aa) |
| | ELK1 | ETS transcription factor ELK1. (515 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | STAT5B | Signal transducer and activator of transcription. (787 aa) |
| | EPS15L1 | Epidermal growth factor receptor pathway substrate 15 like 1. (926 aa) |
| | MTA2 | Metastasis associated 1 family member 2. (668 aa) |
| | GRB7 | Growth factor receptor bound protein 7. (553 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | SHC1 | SHC adaptor protein 1. (577 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (611 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (793 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa) |
| | CSK | Tyrosine-protein kinase. (450 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | GIT1 | GIT ArfGAP 1. (770 aa) |
| | MCF2 | MCF.2 cell line derived transforming sequence. (1058 aa) |
| | PITPNA | Phosphatidylinositol transfer protein alpha. (270 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa) |
| | ERRFI1 | ERBB receptor feedback inhibitor 1. (453 aa) |
| | GRB14-2 | Uncharacterized protein. (225 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (489 aa) |
| | PTPN12 | Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (762 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (859 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4. (1679 aa) |
| | WASL | WASP like actin nucleation promoting factor. (524 aa) |
| | PLCG2 | Phosphoinositide phospholipase C. (1336 aa) |
| | DNM1 | Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa) |
| | SH2D3C | SH2 domain containing 3C. (859 aa) |
| | REPS1 | RALBP1 associated Eps domain containing 1. (745 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | JUND | JunD proto-oncogene, AP-1 transcription factor subunit. (539 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] (366 aa) |
| | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3. (626 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (508 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | DUSP1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (350 aa) |
| | HRAS | Uncharacterized protein. (189 aa) |
| | CEACAM1 | Uncharacterized protein. (524 aa) |
| | GJA1 | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (397 aa) |
| | PTPN9 | SIN3 transcription regulator family member A. (1303 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1671 aa) |
| | JAK2 | Janus kinase 2. (1407 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (552 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa) |
| | AP2A1 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (995 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa) |
| | RALBP1 | RalA binding protein 1. (669 aa) |
| | USP6NL | USP6 N-terminal like. (845 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | PRKAR1A | Protein kinase cAMP-dependent type I regulatory subunit alpha. (385 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | STAT1 | Signal transducer and activator of transcription. (774 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (250 aa) |
| | PXN-2 | Uncharacterized protein. (258 aa) |
| | ATF1 | Activating transcription factor 1. (429 aa) |
| | STAT3 | Signal transducer and activator of transcription. (793 aa) |
| | RASA1 | RAS p21 protein activator 1. (1030 aa) |
| | ARF4 | ADP ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (180 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (758 aa) |
| | RGS8 | Regulator of G protein signaling 8. (240 aa) |
| | EPS8 | Epidermal growth factor receptor pathway substrate 8. (834 aa) |
| | KLF11 | Kruppel like factor 11. (710 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | TNIP1 | TNFAIP3 interacting protein 1. (662 aa) |
| | RALGDS | Uncharacterized protein. (1045 aa) |
| | PLSCR1 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (366 aa) |
| | SNCA | Alpha-synuclein; Belongs to the synuclein family. (204 aa) |
| | PKN2 | Protein kinase N2. (1013 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (892 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (869 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | PEBP1 | Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Involved in the positive regulation of epithelial cell migration. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Belongs to the [...] (243 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3. (517 aa) |
| | ADAMTSL3 | ADAMTS like 3. (1734 aa) |
