STRINGSTRING
RARB RARB ESR1 ESR1 RXRB RXRB NR1H2 NR1H2 PGR PGR NR2C2 NR2C2 PPARG PPARG NR1D2 NR1D2 NR3C1 NR3C1 RARA RARA NR1H3 NR1H3 VDR VDR NR1I3 NR1I3 NR4A2 NR4A2 R3HDML R3HDML NR2F2 NR2F2 NR1I2 NR1I2 NR5A2 NR5A2 RORC RORC ESRRA ESRRA ESR2 ESR2 THRA THRA AR AR ROR1 ROR1 NR6A1 NR6A1 NR2E1 NR2E1 THRB THRB HNF4A HNF4A ESRRB ESRRB RXRG RXRG NR2F6 NR2F6 PPARD PPARD PPARA PPARA RXRA RXRA NR4A1 NR4A1 NR2F1 NR2F1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RARBRetinoic acid receptor beta. (464 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
RXRBRetinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE); Belongs to the nuclear hormone receptor family. NR2 subfamily. (536 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (455 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. (939 aa)
NR2C2Nuclear receptor subfamily 2 group C member 2. (629 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (529 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (576 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (781 aa)
RARARetinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcri [...] (462 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
VDRVitamin D receptor. (432 aa)
NR1I3Nuclear receptor subfamily 1 group I member 3. (348 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
R3HDMLR3H domain containing like; Belongs to the CRISP family. (252 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (471 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (519 aa)
RORCRAR related orphan receptor C. (518 aa)
ESRRASteroid hormone receptor ERR1; Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium- chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. May function as a modulator of the estrogen signaling pathway in the uterus. Induces the expression of PERM1 in the skeletal muscle (By similarity). Belongs to the nuclear hormone receptor family. NR3 subfamily. (613 aa)
ESR2Estrogen receptor 2. (549 aa)
THRAUncharacterized protein. (511 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (907 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1011 aa)
NR6A1Nuclear receptor subfamily 5 group A member 1. (427 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
THRBThyroid hormone receptor beta. (476 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (484 aa)
ESRRBEstrogen related receptor beta. (513 aa)
RXRGRetinoid X receptor gamma. (538 aa)
NR2F6Nuclear receptor subfamily 2 group F member 6. (764 aa)
PPARDPeroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). (473 aa)
PPARAPeroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] (568 aa)
RXRARetinoid X receptor alpha. (556 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). (606 aa)
NR2F1Nuclear receptor subfamily 2 group F member 1. (421 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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