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ACAT2 ACAT2 PPT2 PPT2 MCAT MCAT HACD4 HACD4 ELOVL5 ELOVL5 HADHA HADHA OXSM OXSM FASN FASN HSD17B12 HSD17B12 CBR4 CBR4 ACSL5 ACSL5 ELOVL2 ELOVL2 CPT1A CPT1A ELOVL6 ELOVL6 ACADSB ACADSB EHHADH EHHADH ECHS1 ECHS1 ACADL ACADL ACOX3 ACOX3 FADS1 FADS1 ACADVL ACADVL FADS2 FADS2 TECR TECR HACD3 HACD3 ACACA ACACA ACSBG2 ACSBG2 CPT2 CPT2 ACADM ACADM ACADS ACADS HACD1 HACD1 ACAT1 ACAT1 HADHB HADHB ACSL6 ACSL6 HACD2 HACD2 SCD SCD SCP2 SCP2 SCD5 SCD5 ACSL3 ACSL3 LOC485024 LOC485024 ELOVL4 ELOVL4 ELOVL1 ELOVL1 ACSF3 ACSF3 CPT1C CPT1C HADH HADH PPT1 PPT1 ACOX1 ACOX1 HSD17B4 HSD17B4 ACAA2 ACAA2 ACSL1 ACSL1 ACSL4 ACSL4 ACSBG1 ACSBG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
PPT2Palmitoyl-protein thioesterase 2. (309 aa)
MCATMalonyl-CoA-acyl carrier protein transacylase. (384 aa)
HACD4Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (231 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (762 aa)
OXSM3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa)
FASNFatty acid synthase. (2478 aa)
HSD17B12Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
CBR4Carbonyl reductase 4. (316 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (683 aa)
ELOVL2Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (333 aa)
CPT1AUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
ACADSBAcyl-CoA dehydrogenase short/branched chain. (514 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
ECHS1Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
ACADLAcyl-CoA dehydrogenase long chain. (437 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
FADS1Fatty acid desaturase 1. (360 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (677 aa)
FADS2Fatty acid desaturase 2. (443 aa)
TECRTrans-2,3-enoyl-CoA reductase. (350 aa)
HACD3Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (467 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (686 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (659 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (415 aa)
ACADSAcyl-CoA dehydrogenase short chain. (396 aa)
HACD1Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursor [...] (291 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (433 aa)
HADHBUncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
ACSL6Acyl-CoA synthetase long chain family member 6. (722 aa)
HACD2Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (246 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (355 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (540 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (322 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
LOC485024AMP-binding domain-containing protein. (610 aa)
ELOVL4Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (354 aa)
ACSF3Acyl-CoA synthetase family member 3. (660 aa)
CPT1CCarnitine palmitoyltransferase 1C. (914 aa)
HADHHydroxyacyl-CoA dehydrogenase. (393 aa)
PPT1Palmitoyl-protein thioesterase 1. (473 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (735 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (775 aa)
ACAA2Thiolase_N domain-containing protein. (271 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (746 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (846 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (826 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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