STRINGSTRING
MAP3K5 MAP3K5 BAK1 BAK1 POLH POLH XPA XPA MSH2 MSH2 CYCS CYCS SLC31A1 SLC31A1 BAX BAX ATP7B ATP7B PIK3R3 PIK3R3 ERCC1 ERCC1 MLH1 MLH1 AKT2 AKT2 BCL2L1 BCL2L1 PIK3CB PIK3CB PIK3R1 PIK3R1 CASP3 CASP3 MSH3 MSH3 ABCC2 ABCC2 GSTO1 GSTO1 GSTP1 GSTP1 CASP8 CASP8 MGST1 MGST1 MGST3 MGST3 FASLG FASLG PIK3R2 PIK3R2 BIRC2 BIRC2 FAS FAS AKT3 AKT3 ERBB2 ERBB2 AKT1 AKT1 PIK3CD PIK3CD MAPK1 MAPK1 PMAIP1 PMAIP1 BAD BAD XIAP XIAP ATM ATM APAF1 APAF1 LOC474938 LOC474938 ATP7A ATP7A MSH6 MSH6 TOP2A TOP2A BIRC5 BIRC5 LOC100686488 LOC100686488 PIK3CA PIK3CA BRCA1 BRCA1 BIRC3 BIRC3 CDKN1A CDKN1A REV3L REV3L LOC479911 LOC479911 LOC610304 LOC610304 BID BID PDPK1 PDPK1 GSTA4-2 GSTA4-2 BBC3 BBC3 LOC479912 LOC479912 GSTO2 GSTO2 LOC476006 LOC476006 CASP9 CASP9 TP53 TP53 TOP2B TOP2B MDM2 MDM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
BAK1BCL2 antagonist/killer 1. (243 aa)
POLHDNA polymerase eta. (712 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SLC31A1Solute carrier family 31 member 1. (246 aa)
BAXBCL2 associated X, apoptosis regulator. (180 aa)
ATP7BATPase copper transporting beta. (1434 aa)
PIK3R3Uncharacterized protein. (461 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (314 aa)
MLH1MutL homolog 1. (757 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
BCL2L1BCL2 like 1. (233 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
MSH3MutS homolog 3; Component of the post-replicative DNA mismatch repair system (MMR). (1058 aa)
ABCC2ATP binding cassette subfamily C member 2. (1544 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (361 aa)
GSTP1Uncharacterized protein. (210 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (486 aa)
MGST1Microsomal glutathione S-transferase 1. (166 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (286 aa)
PIK3R2Uncharacterized protein. (726 aa)
BIRC2Baculoviral IAP repeat containing 2. (617 aa)
FASFas cell surface death receptor. (734 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ERBB2Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1263 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family. (54 aa)
BADBCL2 associated agonist of cell death. (167 aa)
XIAPBaculoviral IAP-repeat containing protein 4. (493 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase 9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1250 aa)
LOC474938Uncharacterized protein; Belongs to the GST superfamily. (255 aa)
ATP7AATPase copper transporting alpha. (1499 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1275 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1541 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (533 aa)
LOC100686488GST C-terminal domain-containing protein. (260 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1921 aa)
BIRC3Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] (635 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (357 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3121 aa)
LOC479911Glutathione S-transferase. (294 aa)
LOC610304GST N-terminal domain-containing protein; Belongs to the GST superfamily. (227 aa)
BIDBH3 interacting domain death agonist. (287 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (551 aa)
GSTA4-2Uncharacterized protein; Belongs to the GST superfamily. (222 aa)
BBC3Uncharacterized protein. (293 aa)
LOC479912Uncharacterized protein; Belongs to the GST superfamily. (292 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (337 aa)
LOC476006Uncharacterized protein; Belongs to the GST superfamily. (388 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (489 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1609 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (529 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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