STRINGSTRING
POP1 POP1 RRP7 RRP7 RBM28 RBM28 NOL6 NOL6 RPP25L RPP25L XPO1 XPO1 MDN1 MDN1 GNL2 GNL2 XRN2 XRN2 WDR43 WDR43 FBL FBL GTPBP4 GTPBP4 NOP56 NOP56 RAN RAN CSNK2A1 CSNK2A1 NAT10 NAT10 BMS1 BMS1 WDR36 WDR36 RIOK2 RIOK2 EIF6 EIF6 UTP15 UTP15 GNL3 GNL3 WDR75 WDR75 RIOK1 RIOK1 MPHOSPH10 MPHOSPH10 HEATR1 HEATR1 GAR1 GAR1 NOP58 NOP58 LSG1 LSG1 NXF3 NXF3 EMG1 EMG1 NXF1 NXF1 LOC486757 LOC486757 TSR2 TSR2 FCF1 FCF1 UTP18 UTP18 LOC492026 LOC492026 REXO5 REXO5 IMP3 IMP3 UTP14A UTP14A TBL3 TBL3 REXO1 REXO1 DKC1 DKC1 POP7 POP7 RPP38 RPP38 NXT2 NXT2 NOP10 NOP10 NVL NVL WDR3 WDR3 FGF2 FGF2 CSNK2A2 CSNK2A2 LOC100686305 LOC100686305 XRN1 XRN1 RPP40 RPP40 LOC102152733 LOC102152733 SBDS SBDS NOB1 NOB1 AK6-2 AK6-2 FBLL1 FBLL1 SNU13 SNU13 RPP25 RPP25 EFL1 EFL1 NHP2 NHP2 NMD3 NMD3 UTP6 UTP6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POP1POP1 homolog, ribonuclease P/MRP subunit. (1016 aa)
RRP7Ribosomal RNA processing 7 homolog. (280 aa)
RBM28RNA binding motif protein 28. (751 aa)
NOL6Nucleolar protein 6. (1146 aa)
RPP25LAlba domain-containing protein. (163 aa)
XPO1Exportin 1. (1071 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5592 aa)
GNL2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (731 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa)
WDR43WD repeat domain 43. (681 aa)
FBLFibrillarin. (313 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (686 aa)
NOP56NOP56 ribonucleoprotein. (597 aa)
RANGTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (224 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1025 aa)
BMS1BMS1 ribosome biogenesis factor. (1287 aa)
WDR36WD repeat domain 36. (891 aa)
RIOK2RIO kinase 2. (548 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
UTP15UTP15 small subunit processome component. (516 aa)
GNL3G protein nucleolar 3. (555 aa)
WDR75WD repeat domain 75. (829 aa)
RIOK1Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (569 aa)
MPHOSPH10U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family. (679 aa)
HEATR1HEAT repeat containing 1. (2141 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (210 aa)
NOP58NOP58 ribonucleoprotein. (540 aa)
LSG1Large 60S subunit nuclear export GTPase 1. (626 aa)
NXF3Nuclear RNA export factor 3. (584 aa)
EMG1EMG1 N1-specific pseudouridine methyltransferase. (253 aa)
NXF1Nuclear RNA export factor 1. (630 aa)
LOC486757Alba domain-containing protein. (163 aa)
TSR2G protein nucleolar 3 like. (649 aa)
FCF1PINc domain-containing protein. (198 aa)
UTP18UTP18 small subunit processome component. (566 aa)
LOC492026Uncharacterized protein. (608 aa)
REXO5RNA exonuclease 5. (782 aa)
IMP3IMP U3 small nucleolar ribonucleoprotein 3. (285 aa)
UTP14AUncharacterized protein. (772 aa)
TBL3TNF receptor associated factor 7. (817 aa)
REXO1RNA exonuclease 1 homolog. (1176 aa)
DKC1Dyskerin pseudouridine synthase 1. (683 aa)
POP7Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa)
RPP38Ribonuclease P/MRP subunit p38. (285 aa)
NXT2Nuclear transport factor 2 like export factor 2. (199 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
NVLNuclear VCP like. (855 aa)
WDR3WD repeat domain 3. (943 aa)
FGF2Spermatogenesis associated 5. (898 aa)
CSNK2A2Casein kinase 2 alpha 2. (571 aa)
LOC100686305GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (215 aa)
XRN15'-3' exoribonuclease 1. (1743 aa)
RPP40Ribonuclease P/MRP subunit p40. (492 aa)
LOC102152733Exonuclease domain-containing protein. (932 aa)
SBDSSBDS ribosome maturation factor. (318 aa)
NOB1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (465 aa)
AK6-2Uncharacterized protein. (132 aa)
FBLL1Fibrillarin like 1. (345 aa)
SNU13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (163 aa)
RPP25Ribonuclease P and MRP subunit p25. (199 aa)
EFL1Elongation factor like GTPase 1. (1291 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (228 aa)
NMD360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (585 aa)
UTP6UTP6 small subunit processome component. (670 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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