STRINGSTRING
PRIM1 PRIM1 MCM3 MCM3 POLD2 POLD2 POLD1 POLD1 SSBP1 SSBP1 MCM6 MCM6 PCNA PCNA RFC3 RFC3 MCM4 MCM4 CLCF1 CLCF1 RNASEH2C RNASEH2C POLA1 POLA1 POLA2 POLA2 RFC4 RFC4 DNA2 DNA2 MCM7 MCM7 RNASEH2A RNASEH2A RPA1 RPA1 PRIM2 PRIM2 RNASEH1 RNASEH1 MCM2 MCM2 FEN1 FEN1 RNASEH2B RNASEH2B MCM5 MCM5 RFC2 RFC2 POLE2 POLE2 POLE POLE RPA3 RPA3 POLD3 POLD3 RPA2 RPA2 RFC1 RFC1 LIG1 LIG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRIM1Uncharacterized protein. (185 aa)
MCM3Minichromosome maintenance complex component 3; Belongs to the MCM family. (817 aa)
POLD2DNA polymerase delta 2, accessory subunit. (519 aa)
POLD1DNA polymerase. (1107 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RFC3Replication factor C subunit 3. (356 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
CLCF1Cardiotrophin like cytokine factor 1. (261 aa)
RNASEH2CRibonuclease H2 subunit C. (168 aa)
POLA1DNA polymerase. (1467 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (700 aa)
RFC4Replication factor C subunit 4. (363 aa)
DNA2DNA replication helicase/nuclease 2. (1017 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (502 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
RNASEH1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (285 aa)
MCM2DNA helicase; Belongs to the MCM family. (933 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RNASEH2BRibonuclease H2 subunit B. (356 aa)
MCM5Minichromosome maintenance complex component 5; Belongs to the MCM family. (689 aa)
RFC2Replication factor C subunit 2. (367 aa)
POLE2DNA polymerase epsilon 2, accessory subunit. (640 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2335 aa)
RPA3Uncharacterized protein. (351 aa)
POLD3DNA polymerase delta 3, accessory subunit. (541 aa)
RPA2Replication protein A2. (390 aa)
RFC1Replication factor C subunit 1. (1198 aa)
LIG1DNA ligase. (915 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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