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| | TNFRSF11A | TNF receptor superfamily member 11a. (648 aa) |
| | IL23A | Interleukin 23 subunit alpha. (193 aa) |
| | INHBC | Inhibin subunit beta C. (351 aa) |
| | IL20RA | Interleukin 20 receptor subunit alpha. (558 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (475 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | IL26 | Interleukin 26. (171 aa) |
| | IL22 | Interleukin 22. (179 aa) |
| | LTA | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo (By similarity). (204 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | IL3 | Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa) |
| | TNFRSF11B | Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa) |
| | IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa) |
| | IL13 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa) |
| | CXCL14 | C-X-C motif chemokine ligand 14. (99 aa) |
| | IL33 | Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). (263 aa) |
| | IL2RB | Fibronectin type-III domain-containing protein. (556 aa) |
| | CSF2RB | Colony stimulating factor 2 receptor beta common subunit. (902 aa) |
| | IFNB1 | Interferon-beta. (186 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (340 aa) |
| | IFNK | Interferon kappa. (209 aa) |
| | CNTFR | Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity). (372 aa) |
| | GALT | Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (775 aa) |
| | CCL27 | Cutaneous T cell attracting chemokine. (119 aa) |
| | CCL19 | C-C motif chemokine. (115 aa) |
| | TNFRSF21 | Uncharacterized protein. (623 aa) |
| | IL1RL1 | Interleukin 1 receptor like 1. (557 aa) |
| | IL1RL2 | Interleukin 1 receptor like 2. (578 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (595 aa) |
| | BMP5 | Bone morphogenetic protein 5. (454 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa) |
| | LOC100855618 | TGF_BETA_2 domain-containing protein. (297 aa) |
| | BMP10 | Bone morphogenetic protein 10. (424 aa) |
| | TNFSF8 | Tumor necrosis factor ligand 3A; Belongs to the tumor necrosis factor family. (234 aa) |
| | CSF3R | Colony stimulating factor 3 receptor. (840 aa) |
| | INHBA | Inhibin subunit beta A. (424 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | IL21 | Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity); Bel [...] (146 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa) |
| | CCR4 | C-C chemokine receptor type 4; High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival (By similarity). (360 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (512 aa) |
| | CXCL17 | C-X-C motif chemokine ligand 17. (119 aa) |
| | INHBB-2 | Inhibin subunit beta B. (131 aa) |
| | B9D2 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | ACVR2B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa) |
| | IL2RA | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (268 aa) |
| | IL17RE | Interleukin 17 receptor E. (668 aa) |
| | LOC612539 | Uncharacterized protein. (189 aa) |
| | IL5RA | Interleukin 5 receptor subunit alpha. (420 aa) |
| | ACKR4 | Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa) |
| | IL31RA | Interleukin 31 receptor A. (728 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa) |
| | IL36B | Interleukin-1. (164 aa) |
| | IL36RN | Interleukin-1. (155 aa) |
| | IL20RB | Interleukin 20 receptor subunit beta. (311 aa) |
| | GDF5 | Growth differentiation factor 5. (499 aa) |
| | IL7 | Interleukin 7. (155 aa) |
| | CX3CL1 | Chemokine (C-X3-C motif) ligand 1. (437 aa) |
| | BMP3 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. (463 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (374 aa) |
| | LOC609830 | Uncharacterized protein. (569 aa) |
| | MSTN | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa) |
| | NGF | Nerve growth factor; Belongs to the NGF-beta family. (240 aa) |
| | PRL | Prolactin. (229 aa) |
| | CCL20 | C-C motif chemokine ligand 20. (97 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CRLF2 | Cytokine receptor like factor 2. (373 aa) |
| | CSF2RA | Colony stimulating factor 2 receptor alpha subunit. (576 aa) |
| | IL3RA | Interleukin 3 receptor subunit alpha. (489 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa) |
| | IL19 | Interleukin 19. (177 aa) |
| | IL20 | Interleukin 20. (176 aa) |
| | IL24 | Interleukin 24. (192 aa) |
| | IL29L | Interferon lambda. (190 aa) |
| | IL25 | Interleukin 25. (161 aa) |
| | ACKR3 | Atypical chemokine receptor 3; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein- mediated signal transduction but instead induces beta-arrestin recruitment, lead [...] (362 aa) |
| | CXCR5 | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa) |
| | OSM | Oncostatin M. (247 aa) |
| | GH1 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (449 aa) |
| | CCR5 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa) |
| | CCR2 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | CCR3 | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. (360 aa) |
| | XCR1 | X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (330 aa) |
| | IL16 | Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1376 aa) |
| | CXCR6 | C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (341 aa) |
| | CCR9 | Chemokine C-C motif receptor 9; Belongs to the G-protein coupled receptor 1 family. (367 aa) |
| | IL1RAP | Interleukin 1 receptor accessory protein. (685 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa) |
| | EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (200 aa) |
| | TNFSF4 | Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa) |
| | TNFSF18 | TNF superfamily member 18. (190 aa) |
| | CXCR2 | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (358 aa) |
| | FASLG | Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (286 aa) |
| | BMP4 | TGF_BETA_2 domain-containing protein. (409 aa) |
| | GDF15 | Growth differentiation factor 15. (307 aa) |
| | IL12RB1 | Interleukin 12 receptor subunit beta 1. (732 aa) |
| | INHA | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa) |
| | FAS | Fas cell surface death receptor. (734 aa) |
| | CXCL16 | C-X-C motif chemokine ligand 16. (441 aa) |
| | BMP15 | Bone morphogenetic protein 15. (393 aa) |
| | IL17RA | Interleukin 17 receptor A. (866 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | GDF2 | Growth differentiation factor 2. (420 aa) |
| | CTF1 | Uncharacterized protein. (201 aa) |
| | TGFB3 | Transforming growth factor beta 3. (457 aa) |
| | CXCR3 | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). (368 aa) |
| | IL6R | Interleukin 6 receptor. (468 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa) |
| | EPOR | Erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity). (508 aa) |
| | CCL16 | C-C motif chemokine. (117 aa) |
| | CCL14 | C-C motif chemokine. (94 aa) |
| | CCL8 | C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity). (99 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (162 aa) |
| | CCL25 | C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (164 aa) |
| | TNFRSF13B | TNF receptor superfamily member 13B. (289 aa) |
| | IL12RB2 | Interleukin 12 receptor subunit beta 2. (858 aa) |
| | IL23R | Interleukin 23 receptor. (631 aa) |
| | LEPR | Leptin receptor. (1166 aa) |
| | OSMR | Oncostatin M receptor. (968 aa) |
| | IL7R | Interleukin 7 receptor. (456 aa) |
| | CD40LG | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa) |
| | TNFRSF4 | TNF receptor superfamily member 4. (385 aa) |
| | TNFRSF18 | TNF receptor superfamily member 18. (322 aa) |
| | TNFRSF12A | Uncharacterized protein. (129 aa) |
| | TNFRSF14 | TNF receptor superfamily member 14. (272 aa) |
| | TNFRSF9 | TNF receptor superfamily member 9. (255 aa) |
| | LOC611642 | Fibronectin type-III domain-containing protein. (505 aa) |
| | IL17C | Interleukin 17C. (197 aa) |
| | IL13RA1 | Interleukin 13 receptor subunit alpha 1. (427 aa) |
| | CCL28 | C-C motif chemokine 28; Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity); Belongs to the intercrine beta (chemokine CC) family. (178 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa) |
| | CXCL10 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] (98 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa) |
| | MPL | MPL proto-oncogene, thrombopoietin receptor. (535 aa) |
| | CCR10 | C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (363 aa) |
| | CXCL6 | C-X-C motif chemokine. (115 aa) |
| | CXCL13 | C-X-C motif chemokine. (110 aa) |
| | TNFSF13B | Tumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family. (370 aa) |
| | LIF | LIF interleukin 6 family cytokine. (202 aa) |
| | CD70 | CD70 molecule; Belongs to the tumor necrosis factor family. (199 aa) |
| | J9NRS1_CANLF | SCY domain-containing protein. (213 aa) |
| | CCL22 | C-C motif chemokine. (93 aa) |
| | IL27 | Interleukin 27. (232 aa) |
| | IL1RN | Interleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity). Belongs to the IL-1 family. (158 aa) |
| | CXCL12 | SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (117 aa) |
| | EDA | Ectodysplasin A isoform EDA-A2; Belongs to the tumor necrosis factor family. (386 aa) |
| | IL21R | Interleukin 21 receptor. (543 aa) |
| | TNFRSF17 | TNF receptor superfamily member 17. (175 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (205 aa) |
| | BMP6 | Bone morphogenetic protein 6. (335 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (273 aa) |
| | NODAL | Nodal growth differentiation factor. (378 aa) |
| | LOC100686341 | Fibronectin type-III domain-containing protein. (402 aa) |
| | GDF7 | TGF_BETA_2 domain-containing protein. (755 aa) |
| | IL17RB | Interleukin 17 receptor B. (476 aa) |
| | TNFSF15 | TNF superfamily member 15. (285 aa) |
| | LTB | Tumor necrosis factor ligand 1C; Belongs to the tumor necrosis factor family. (247 aa) |
| | PPBP | SCY domain-containing protein. (118 aa) |
| | LOC480601 | SCY domain-containing protein. (94 aa) |
| | IL31 | Interleukin 31. (159 aa) |
| | CCL26 | C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils. (94 aa) |
| | IL1F10 | Interleukin-1. (177 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa) |
| | TSLP | Thymic stromal lymphopoietin. (117 aa) |
| | BMP7 | Bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). (653 aa) |
| | TNFRSF6B | TNF receptor superfamily member 6b. (305 aa) |
| | IL2RG | Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. (373 aa) |
| | IL37 | Interleukin-1. (288 aa) |
| | TNFSF14 | Tumor necrosis factor ligand 1D; Belongs to the tumor necrosis factor family. (240 aa) |
| | IL17D | Uncharacterized protein. (181 aa) |
| | GDF3 | Growth differentiation factor 3. (365 aa) |
| | CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa) |
| | LTBR | Lymphotoxin beta receptor. (421 aa) |
| | CX3CR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (384 aa) |
| | IL22RA1 | Interleukin 22 receptor subunit alpha 1. (578 aa) |
| | NGFR | Nerve growth factor receptor. (429 aa) |
| | IFNLR1 | Interferon lambda receptor 1. (502 aa) |
| | CCL23 | SCY domain-containing protein. (119 aa) |
| | IL4R | Interleukin 4 receptor. (835 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (470 aa) |
| | IL17A | Interleukin 17A. (156 aa) |
| | BMPR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa) |
| | LOC111098084 | Uncharacterized protein. (87 aa) |
| | IFNGR2 | Uncharacterized protein. (435 aa) |
| | CCL4 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (97 aa) |
| | LOC100683416 | Uncharacterized protein. (178 aa) |
| | IFNA5 | Interferon alpha-3; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (629 aa) |
| | LOC100687692 | Uncharacterized protein. (187 aa) |
| | LOC100683202 | Interferon alpha-1/2; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | PRLR | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (625 aa) |
| | ACVR1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (581 aa) |
| | LIFR | Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity). (1157 aa) |
| | BMP2 | Bone morphogenetic protein 2. (436 aa) |
| | CCL17 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). (195 aa) |
| | CCL1 | C-C motif chemokine. (94 aa) |
| | IFNAR1 | Uncharacterized protein. (572 aa) |
| | TNFSF12 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (420 aa) |
| | AMHR2 | Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (565 aa) |
| | LOC100686162 | Uncharacterized protein. (175 aa) |
| | TNFRSF19 | TNF receptor superfamily member 19. (432 aa) |
| | IFNA7 | Interferon-alpha. (187 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa) |
| | CSF1R | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (482 aa) |
| | LOC100687857 | Uncharacterized protein. (187 aa) |
| | CCR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (355 aa) |
| | LOC100688321 | Uncharacterized protein. (404 aa) |
| | TNFSF13 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (252 aa) |
| | IL18R1 | Interleukin 18 receptor 1. (718 aa) |
| | CXCL11 | C-X-C motif chemokine ligand 11. (92 aa) |
| | LOC489915 | Uncharacterized protein. (185 aa) |
| | ACVR2A | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (735 aa) |
| | IL9 | Interleukin 9. (139 aa) |
| | IL34 | Interleukin 34. (261 aa) |
| | IL13RA2 | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13); Belongs to the type I cytokine receptor family. Type 5 subfamily. (406 aa) |
| | LOC487739 | Uncharacterized protein. (363 aa) |
| | RELT | RELT TNF receptor. (471 aa) |
| | GHR | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). (645 aa) |
| | IFNAR2 | Uncharacterized protein. (522 aa) |
| | CSF1 | Colony stimulating factor 1. (587 aa) |
| | IL17F | Interleukin 17F. (196 aa) |
| | CD40 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (355 aa) |
| | CCL24 | C-C motif chemokine 24; Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (232 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (752 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (296 aa) |
| | IL6ST | Uncharacterized protein. (954 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa) |
| | CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (144 aa) |
| | CCL3 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (159 aa) |
| | LOC100683567 | Uncharacterized protein. (196 aa) |
| | CSF3 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes; Belongs to the IL-6 superfamily. (204 aa) |
| | IL17RC | Interleukin 17 receptor C. (717 aa) |
| | IL17B | Interleukin 17B. (213 aa) |
| | GDF9 | Growth differentiation factor 9. (546 aa) |
| | THPO | Thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. (352 aa) |
