STRINGSTRING
TNFRSF11A TNFRSF11A MALT1 MALT1 TICAM2 TICAM2 TNFAIP3 TNFAIP3 TAB2 TAB2 LTA LTA TNF TNF TAB1 TAB1 DDX58 DDX58 CCL19 CCL19 CXCL8 CXCL8 MAP3K7 MAP3K7 RELB RELB TNFSF11 TNFSF11 MYD88 MYD88 PRKCQ PRKCQ CARD14 CARD14 TRAF6 TRAF6 CSNK2A1 CSNK2A1 BCL2L1 BCL2L1 IL1B IL1B RIPK1 RIPK1 CHUK CHUK IRAK4 IRAK4 NFKB2 NFKB2 LCK LCK CFLAR CFLAR RELA RELA NFKBIA NFKBIA TAB3 TAB3 PTGS2 PTGS2 MAP3K14 MAP3K14 BIRC2 BIRC2 PLAU PLAU PARP1 PARP1 CARD11 CARD11 LAT LAT TRIM25 TRIM25 PRKCB PRKCB ICAM1 ICAM1 TRAF3 TRAF3 CD40LG CD40LG PIAS4 PIAS4 GADD45B GADD45B TRAF2 TRAF2 IKBKG IKBKG PLCG2 PLCG2 VCAM1 VCAM1 BCL10 BCL10 TRADD TRADD TIRAP TIRAP TRAF1 TRAF1 TLR4 TLR4 TICAM1 TICAM1 XIAP XIAP LBP LBP TNFSF13B TNFSF13B ATM ATM CXCL12 CXCL12 EDA EDA UBE2I UBE2I CARD10 CARD10 LTB LTB TNFSF14 TNFSF14 LTBR LTBR BTK BTK CCL4 CCL4 IL1R1 IL1R1 GADD45A GADD45A LYN LYN PLCG1 PLCG1 EDARADD EDARADD CSNK2A2 CSNK2A2 IKBKB IKBKB BIRC3 BIRC3 BLNK BLNK BCL2A1 BCL2A1 SYK SYK NFKB1 NFKB1 ERC1 ERC1 CYLD CYLD CD40 CD40 TNFRSF1A TNFRSF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFRSF11ATNF receptor superfamily member 11a. (648 aa)
MALT1MALT1 paracaspase. (758 aa)
TICAM2TIR domain-containing protein. (238 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo (By similarity). (204 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
DDX58DExD/H-box helicase 58. (925 aa)
CCL19C-C motif chemokine. (115 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RELBRELB proto-oncogene, NF-kB subunit. (560 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (512 aa)
MYD88MYD88 innate immune signal transduction adaptor. (398 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
CARD14Caspase recruitment domain family member 14. (1029 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
BCL2L1BCL2 like 1. (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (669 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (466 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
LCKTyrosine-protein kinase. (509 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (491 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
BIRC2Baculoviral IAP repeat containing 2. (617 aa)
PLAUPlasminogen activator, urokinase. (543 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
LATLinker for activation of T cells. (290 aa)
TRIM25Tripartite motif containing 25. (631 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (531 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
PIAS4Protein inhibitor of activated STAT 4. (521 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
VCAM1Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation (By similarity). (823 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
TIRAPTIR domain containing adaptor protein. (406 aa)
TRAF1TNF receptor associated factor 1. (368 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa)
XIAPBaculoviral IAP-repeat containing protein 4. (493 aa)
LBPLipopolysaccharide binding protein. (481 aa)
TNFSF13BTumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family. (370 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (117 aa)
EDAEctodysplasin A isoform EDA-A2; Belongs to the tumor necrosis factor family. (386 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (192 aa)
CARD10Caspase recruitment domain family member 10. (1207 aa)
LTBTumor necrosis factor ligand 1C; Belongs to the tumor necrosis factor family. (247 aa)
TNFSF14Tumor necrosis factor ligand 1D; Belongs to the tumor necrosis factor family. (240 aa)
LTBRLymphotoxin beta receptor. (421 aa)
BTKTyrosine-protein kinase. (687 aa)
CCL4C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (97 aa)
IL1R1Interleukin 1 receptor type 1. (629 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (246 aa)
LYNTyrosine-protein kinase. (566 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
EDARADDEDAR associated death domain. (216 aa)
CSNK2A2Casein kinase 2 alpha 2. (571 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BIRC3Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] (635 aa)
BLNKB cell linker. (483 aa)
BCL2A1BCL2 related protein A1. (389 aa)
SYKTyrosine-protein kinase. (699 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1120 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (972 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (355 aa)
TNFRSF1ATNF receptor superfamily member 1A. (752 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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