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PIP4K2C PIP4K2C IP6K3 IP6K3 PIP5K1B PIP5K1B IPPK IPPK INPP4A INPP4A CALM2 CALM2 PRKCG PRKCG INPP5B INPP5B INPP4B INPP4B PIP4K2A PIP4K2A F1PIN6_CANLF F1PIN6_CANLF PIK3R3 PIK3R3 PLCD1 PLCD1 ITPKC ITPKC CALML5 CALML5 MTMR14 MTMR14 INPPL1 INPPL1 PLCB4 PLCB4 ITPR1 ITPR1 CDS2 CDS2 CDS1 CDS1 MTMR7 MTMR7 IMPAD1 IMPAD1 PIK3CB PIK3CB PIK3R1 PIK3R1 PLCE1 PLCE1 PIP4P2 PIP4P2 PLCB2 PLCB2 ITPKA ITPKA PIK3C2B PIK3C2B ITPK1 ITPK1 PRKCA PRKCA ITPR2 ITPR2 IP6K2 IP6K2 MTMR3 MTMR3 PLCZ1 PLCZ1 PIP5K1A PIP5K1A PI4KB PI4KB PLCD3 PLCD3 PIK3R2 PIK3R2 PI4KA PI4KA ITPKB ITPKB PI4K2B PI4K2B DGKE DGKE CALML4 CALML4 PRKCB PRKCB PIK3C3 PIK3C3 OCRL OCRL MTM1 MTM1 PIP5K1C PIP5K1C CALML6 CALML6 INPP5E INPP5E PIK3CD PIK3CD PLCG2 PLCG2 PLCB3 PLCB3 PPIP5K1 PPIP5K1 IP6K1 IP6K1 DGKB DGKB PLCD4 PLCD4 PIK3C2A PIK3C2A MTMR1 MTMR1 INPP1 INPP1 IMPA1 IMPA1 CDIPT CDIPT PTEN PTEN SYNJ2 SYNJ2 PLCG1 PLCG1 PPIP5K2 PPIP5K2 MTMR6 MTMR6 PIK3CA PIK3CA ITPR3 ITPR3 DGKH DGKH DGKA DGKA SYNJ1 SYNJ1 PIK3C2G PIK3C2G INPP5F INPP5F INPP5D INPP5D PIKFYVE PIKFYVE DGKG DGKG PLCB1 PLCB1 SACM1L SACM1L INPP5A INPP5A DGKI DGKI IMPA2 IMPA2 PGAM1 PGAM1 PIP4K2B PIP4K2B DGKD DGKD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (352 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (407 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (543 aa)
IPPKInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (581 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (978 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (750 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (944 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
F1PIN6_CANLFUncharacterized protein; Belongs to the calmodulin family. (364 aa)
PIK3R3Uncharacterized protein. (461 aa)
PLCD1Phosphoinositide phospholipase C. (855 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (659 aa)
CALML5Calmodulin like 5. (169 aa)
MTMR14Myotubularin related protein 14. (648 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2628 aa)
CDS2Phosphatidate cytidylyltransferase; Belongs to the CDS family. (574 aa)
CDS1Phosphatidate cytidylyltransferase; Belongs to the CDS family. (519 aa)
MTMR7Myotubularin related protein 7. (817 aa)
IMPAD1Inositol monophosphatase domain containing 1. (360 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PLCE1Phosphoinositide phospholipase C. (2309 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (227 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (453 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase. (486 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
MTMR3Myotubularin related protein 3. (1062 aa)
PLCZ1Phosphoinositide phospholipase C. (636 aa)
PIP5K1APIPK domain-containing protein. (562 aa)
PI4KBPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (833 aa)
PLCD3Phosphoinositide phospholipase C. (750 aa)
PIK3R2Uncharacterized protein. (726 aa)
PI4KAPhosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2101 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (936 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2 beta. (440 aa)
DGKEDiacylglycerol kinase. (564 aa)
CALML4Calmodulin like 4. (120 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (881 aa)
MTM1Myotubularin 1. (654 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
CALML6Calmodulin like 6. (156 aa)
INPP5EInositol polyphosphate-5-phosphatase E. (622 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1528 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (441 aa)
DGKBDiacylglycerol kinase. (803 aa)
PLCD4Phosphoinositide phospholipase C. (815 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1693 aa)
MTMR1Myotubularin related protein 1. (638 aa)
INPP1Inositol polyphosphate-1-phosphatase. (400 aa)
IMPA1Inositol-1-monophosphatase. (277 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (411 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
SYNJ2Synaptojanin 2. (1526 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1273 aa)
MTMR6Myotubularin related protein 6. (779 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2689 aa)
DGKHDiacylglycerol kinase. (1199 aa)
DGKADiacylglycerol kinase. (803 aa)
SYNJ1Uncharacterized protein. (1574 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1477 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1147 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1501 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2112 aa)
DGKGDiacylglycerol kinase. (790 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
SACM1LSAC1 like phosphatidylinositide phosphatase. (594 aa)
INPP5AInositol polyphosphate-5-phosphatase A; Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. (430 aa)
DGKIDiacylglycerol kinase. (1210 aa)
IMPA2Inositol-1-monophosphatase. (296 aa)
PGAM1PI3K/PI4K domain-containing protein. (569 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (441 aa)
DGKDDiacylglycerol kinase. (1312 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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