STRINGSTRING
GRM6 GRM6 AVPR1A AVPR1A GRM1 GRM1 PDGFRB PDGFRB AGPAT4 AGPAT4 ADCY8 ADCY8 GRM4 GRM4 CYTH4 CYTH4 PIP5K1B PIP5K1B KIT KIT SHC3 SHC3 CXCL8 CXCL8 EGFR EGFR GAB1 GAB1 SPHK2 SPHK2 PIK3CG PIK3CG CYTH2 CYTH2 ADCY3 ADCY3 PIK3R3 PIK3R3 GAB2 GAB2 RALB RALB RAF1 RAF1 SPHK1 SPHK1 AKT2 AKT2 PLCB4 PLCB4 SOS1 SOS1 MRAS MRAS PIK3CB PIK3CB PIK3R1 PIK3R1 RRAS2 RRAS2 PDGFC PDGFC PTPN11 PTPN11 PLCB2 PLCB2 RAPGEF3 RAPGEF3 F2R F2R NRAS NRAS PLA2G4D PLA2G4D PLA2G4F PLA2G4F GRM2 GRM2 AVPR1B AVPR1B ADCY2 ADCY2 MS4A2 MS4A2 ARF1 ARF1 AGPAT3 AGPAT3 GNA13 GNA13 PRKCA PRKCA EGF EGF FCER1A FCER1A AGT AGT ADCY4 ADCY4 PIP5K1A PIP5K1A FCER1G FCER1G PLA2G4A PLA2G4A LPAR2 LPAR2 SOS2 SOS2 CXCR2 CXCR2 SHC4 SHC4 DNM3 DNM3 PIK3R2 PIK3R2 CYTH3 CYTH3 AKT3 AKT3 MTOR MTOR SHC1 SHC1 LPAR4 LPAR4 PIK3R6 PIK3R6 DGKE DGKE PIK3R5 PIK3R5 DNM2 DNM2 AKT1 AKT1 PIP5K1C PIP5K1C AVPR2 AVPR2 AGPAT2 AGPAT2 SHC2 SHC2 PLPP2 PLPP2 PIK3CD PIK3CD TSC1 TSC1 PLCG2 PLCG2 DNM1 DNM1 LPAR3 LPAR3 PTGFR PTGFR RHOA RHOA MAPK1 MAPK1 GRM5 GRM5 LPAR1 LPAR1 PLCB3 PLCB3 GRM3 GRM3 LPAR6 LPAR6 ARL17A ARL17A RALA RALA GNA12 GNA12 TSC2 TSC2 INSR INSR DGKB DGKB ADCY6 ADCY6 AGTR1 AGTR1 LOC102155967 LOC102155967 HRAS HRAS JMJD7 JMJD7 ADCY9 ADCY9 MAP2K2 MAP2K2 LOC102155828 LOC102155828 RRAS RRAS MAP2K1 MAP2K1 PLCG1 PLCG1 GRM8 GRM8 PIK3CA PIK3CA GRB2 GRB2 RHEB RHEB DGKH DGKH INS INS AGPAT1 AGPAT1 DGKA DGKA ARF6 ARF6 PTK2B PTK2B SYK SYK PDGFA PDGFA CYTH1 CYTH1 PDGFB PDGFB PLA2G4E PLA2G4E RALGDS RALGDS ENSCAFP00000058227 ENSCAFP00000058227 DGKG DGKG PLCB1 PLCB1 GRM7 GRM7 DGKI DGKI AGPAT5 AGPAT5 PLPP1 PLPP1 LOC111091602 LOC111091602 PDGFRA PDGFRA DGKD DGKD KITLG KITLG
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRM6Glutamate metabotropic receptor 6. (876 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (414 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] (1099 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
GRM4Glutamate metabotropic receptor 4. (865 aa)
CYTH4Cytohesin 4. (394 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (543 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
SHC3SHC adaptor protein 3. (458 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa)
EGFRReceptor protein-tyrosine kinase. (1141 aa)
GAB1GRB2 associated binding protein 1. (701 aa)
SPHK2Sphingosine kinase 2. (733 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1104 aa)
CYTH2Cytohesin 2. (543 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PIK3R3Uncharacterized protein. (461 aa)
GAB2GRB2 associated binding protein 2. (663 aa)
RALBRAS like proto-oncogene B. (206 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SPHK1Sphingosine kinase 1. (487 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
RRAS2RAS related 2. (193 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (328 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (866 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (401 aa)
NRASUncharacterized protein. (189 aa)
PLA2G4DPhospholipase A2. (812 aa)
PLA2G4FPhospholipase A2. (870 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1051 aa)
MS4A2Membrane spanning 4-domains A2. (243 aa)
ARF1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (343 aa)
GNA13G protein subunit alpha 13. (282 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa)
FCER1AFc fragment of IgE receptor Ia. (357 aa)
AGTAngiotensinogen; Belongs to the serpin family. (539 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PIP5K1APIPK domain-containing protein. (562 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
PLA2G4APhospholipase A2. (749 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa)
CXCR2C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (358 aa)
SHC4SHC adaptor protein 4. (632 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (815 aa)
PIK3R2Uncharacterized protein. (726 aa)
CYTH3Cytohesin 3. (369 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
SHC1SHC adaptor protein 1. (577 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
DGKEDiacylglycerol kinase. (564 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (874 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
AVPR2Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity). (501 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (274 aa)
SHC2Uncharacterized protein. (636 aa)
PLPP2Phospholipid phosphatase 2. (545 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
TSC1TSC complex subunit 1. (1169 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
PTGFRProstaglandin F2-alpha receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
GRM5Glutamate metabotropic receptor 5. (1238 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GRM3Glutamate metabotropic receptor 3. (875 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (345 aa)
ARL17AUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
RALARAS like proto-oncogene A. (206 aa)
GNA12G protein subunit alpha 12. (294 aa)
TSC2TSC complex subunit 2. (1783 aa)
INSRTyrosine-protein kinase receptor. (1406 aa)
DGKBDiacylglycerol kinase. (803 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of prot [...] (1291 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. (388 aa)
LOC102155967Uncharacterized protein. (237 aa)
HRASUncharacterized protein. (189 aa)
JMJD7Phospholipase A2. (841 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
LOC102155828Uncharacterized protein. (243 aa)
RRASRAS related. (293 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
RHEBRas homolog, mTORC1 binding. (232 aa)
DGKHDiacylglycerol kinase. (1199 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (371 aa)
DGKADiacylglycerol kinase. (803 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
SYKTyrosine-protein kinase. (699 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (423 aa)
CYTH1Cytohesin 1. (433 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (341 aa)
PLA2G4EPhospholipase A2. (891 aa)
RALGDSUncharacterized protein. (1045 aa)
ENSCAFP00000058227Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (208 aa)
DGKGDiacylglycerol kinase. (790 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
DGKIDiacylglycerol kinase. (1210 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (303 aa)
PLPP1Phospholipid phosphatase 1. (284 aa)
LOC111091602Uncharacterized protein. (265 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1283 aa)
DGKDDiacylglycerol kinase. (1312 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins. (335 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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