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| GRM6 | Glutamate metabotropic receptor 6. (876 aa) | ||||
| AVPR1A | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (414 aa) | ||||
| GRM1 | Glutamate metabotropic receptor 1. (1195 aa) | ||||
| PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] (1099 aa) | ||||
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa) | ||||
| ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa) | ||||
| GRM4 | Glutamate metabotropic receptor 4. (865 aa) | ||||
| CYTH4 | Cytohesin 4. (394 aa) | ||||
| PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (543 aa) | ||||
| KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa) | ||||
| SHC3 | SHC adaptor protein 3. (458 aa) | ||||
| CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa) | ||||
| EGFR | Receptor protein-tyrosine kinase. (1141 aa) | ||||
| GAB1 | GRB2 associated binding protein 1. (701 aa) | ||||
| SPHK2 | Sphingosine kinase 2. (733 aa) | ||||
| PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1104 aa) | ||||
| CYTH2 | Cytohesin 2. (543 aa) | ||||
| ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa) | ||||
| PIK3R3 | Uncharacterized protein. (461 aa) | ||||
| GAB2 | GRB2 associated binding protein 2. (663 aa) | ||||
| RALB | RAS like proto-oncogene B. (206 aa) | ||||
| RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) | ||||
| SPHK1 | Sphingosine kinase 1. (487 aa) | ||||
| AKT2 | AKT serine/threonine kinase 2. (557 aa) | ||||
| PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) | ||||
| SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa) | ||||
| MRAS | Muscle RAS oncogene homolog. (208 aa) | ||||
| PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) | ||||
| PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) | ||||
| RRAS2 | RAS related 2. (193 aa) | ||||
| PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (328 aa) | ||||
| PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) | ||||
| PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa) | ||||
| RAPGEF3 | Rap guanine nucleotide exchange factor 3. (866 aa) | ||||
| F2R | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (401 aa) | ||||
| NRAS | Uncharacterized protein. (189 aa) | ||||
| PLA2G4D | Phospholipase A2. (812 aa) | ||||
| PLA2G4F | Phospholipase A2. (870 aa) | ||||
| GRM2 | Glutamate metabotropic receptor 2. (872 aa) | ||||
| AVPR1B | Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa) | ||||
| ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1051 aa) | ||||
| MS4A2 | Membrane spanning 4-domains A2. (243 aa) | ||||
| ARF1 | Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa) | ||||
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3. (343 aa) | ||||
| GNA13 | G protein subunit alpha 13. (282 aa) | ||||
| PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa) | ||||
| EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa) | ||||
| FCER1A | Fc fragment of IgE receptor Ia. (357 aa) | ||||
| AGT | Angiotensinogen; Belongs to the serpin family. (539 aa) | ||||
| ADCY4 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa) | ||||
| PIP5K1A | PIPK domain-containing protein. (562 aa) | ||||
| FCER1G | Fc fragment of IgE receptor Ig. (86 aa) | ||||
| PLA2G4A | Phospholipase A2. (749 aa) | ||||
| LPAR2 | Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa) | ||||
| SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa) | ||||
| CXCR2 | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (358 aa) | ||||
| SHC4 | SHC adaptor protein 4. (632 aa) | ||||
| DNM3 | Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (815 aa) | ||||
| PIK3R2 | Uncharacterized protein. (726 aa) | ||||
| CYTH3 | Cytohesin 3. (369 aa) | ||||
| AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) | ||||
| MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa) | ||||
| SHC1 | SHC adaptor protein 1. (577 aa) | ||||
| LPAR4 | Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa) | ||||
| PIK3R6 | Phosphoinositide-3-kinase regulatory subunit 6. (755 aa) | ||||
| DGKE | Diacylglycerol kinase. (564 aa) | ||||
| PIK3R5 | Phosphoinositide-3-kinase regulatory subunit 5. (874 aa) | ||||
| DNM2 | Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa) | ||||
| AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) | ||||
| PIP5K1C | Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa) | ||||
| AVPR2 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity). (501 aa) | ||||
| AGPAT2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (274 aa) | ||||
| SHC2 | Uncharacterized protein. (636 aa) | ||||
| PLPP2 | Phospholipid phosphatase 2. (545 aa) | ||||
| PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa) | ||||
| TSC1 | TSC complex subunit 1. (1169 aa) | ||||
| PLCG2 | Phosphoinositide phospholipase C. (1336 aa) | ||||
| DNM1 | Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa) | ||||
| LPAR3 | Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa) | ||||
| PTGFR | Prostaglandin F2-alpha receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa) | ||||
| RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa) | ||||
| MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) | ||||
| GRM5 | Glutamate metabotropic receptor 5. (1238 aa) | ||||
| LPAR1 | Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa) | ||||
| PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa) | ||||
| GRM3 | Glutamate metabotropic receptor 3. (875 aa) | ||||
| LPAR6 | Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (345 aa) | ||||
| ARL17A | Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa) | ||||
| RALA | RAS like proto-oncogene A. (206 aa) | ||||
| GNA12 | G protein subunit alpha 12. (294 aa) | ||||
| TSC2 | TSC complex subunit 2. (1783 aa) | ||||
| INSR | Tyrosine-protein kinase receptor. (1406 aa) | ||||
| DGKB | Diacylglycerol kinase. (803 aa) | ||||
| ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of prot [...] (1291 aa) | ||||
| AGTR1 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. (388 aa) | ||||
| LOC102155967 | Uncharacterized protein. (237 aa) | ||||
| HRAS | Uncharacterized protein. (189 aa) | ||||
| JMJD7 | Phospholipase A2. (841 aa) | ||||
| ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa) | ||||
| MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa) | ||||
| LOC102155828 | Uncharacterized protein. (243 aa) | ||||
| RRAS | RAS related. (293 aa) | ||||
| MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa) | ||||
| PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa) | ||||
| GRM8 | Glutamate metabotropic receptor 8. (908 aa) | ||||
| PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) | ||||
| GRB2 | Growth factor receptor bound protein 2. (250 aa) | ||||
| RHEB | Ras homolog, mTORC1 binding. (232 aa) | ||||
| DGKH | Diacylglycerol kinase. (1199 aa) | ||||
| INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa) | ||||
| AGPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (371 aa) | ||||
| DGKA | Diacylglycerol kinase. (803 aa) | ||||
| ARF6 | ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa) | ||||
| PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) | ||||
| SYK | Tyrosine-protein kinase. (699 aa) | ||||
| PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (423 aa) | ||||
| CYTH1 | Cytohesin 1. (433 aa) | ||||
| PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (341 aa) | ||||
| PLA2G4E | Phospholipase A2. (891 aa) | ||||
| RALGDS | Uncharacterized protein. (1045 aa) | ||||
| ENSCAFP00000058227 | Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (208 aa) | ||||
| DGKG | Diacylglycerol kinase. (790 aa) | ||||
| PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa) | ||||
| GRM7 | Glutamate metabotropic receptor 7. (922 aa) | ||||
| DGKI | Diacylglycerol kinase. (1210 aa) | ||||
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5. (303 aa) | ||||
| PLPP1 | Phospholipid phosphatase 1. (284 aa) | ||||
| LOC111091602 | Uncharacterized protein. (265 aa) | ||||
| PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1283 aa) | ||||
| DGKD | Diacylglycerol kinase. (1312 aa) | ||||
| KITLG | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins. (335 aa) | ||||