STRINGSTRING
FBXO43 FBXO43 MAPK12 MAPK12 SKP1 SKP1 ADCY8 ADCY8 CDC23 CDC23 CDC25C CDC25C MAPK13 MAPK13 PPP2R5D PPP2R5D CALM2 CALM2 CUL1 CUL1 PGR PGR ADCY3 ADCY3 F1PIN6_CANLF F1PIN6_CANLF CALML5 CALML5 SGO1 SGO1 ANAPC11 ANAPC11 ITPR1 ITPR1 PPP2CB PPP2CB ESPL1 ESPL1 ANAPC10 ANAPC10 CCNE1 CCNE1 ANAPC5 ANAPC5 ANAPC7 ANAPC7 CCNE2 CCNE2 YWHAB YWHAB BTRC BTRC ADCY2 ADCY2 SLK SLK PPP3CA PPP3CA ITPR2 ITPR2 PPP1CA PPP1CA REC8 REC8 CAMK2D CAMK2D ADCY4 ADCY4 PPP2R5A PPP2R5A RPS6KA1 RPS6KA1 PLCZ1 PLCZ1 CDK1 CDK1 RPS6KA3 RPS6KA3 CDC27 CDC27 PPP2R1B PPP2R1B STAG3 STAG3 SMC1A SMC1A ANAPC4 ANAPC4 MAD2L1 MAD2L1 MAD1L1 MAD1L1 MAD2L2 MAD2L2 CCNB2 CCNB2 AR AR CALML4 CALML4 CALML6 CALML6 ANAPC2 ANAPC2 PRKACB PRKACB PPP1CC PPP1CC CCNB1 CCNB1 LOC100682940 LOC100682940 MAPK1 MAPK1 PPP2CA PPP2CA YWHAG YWHAG FBXO5 FBXO5 AURKA AURKA PLK1 PLK1 ADCY6 ADCY6 CDC26 CDC26 PPP3CC PPP3CC SPDYA SPDYA ADCY9 ADCY9 J9P9F2_CANLF J9P9F2_CANLF YWHAZ-2 YWHAZ-2 SMC1B SMC1B SPDYC SPDYC PTTG1 PTTG1 FBXW11 FBXW11 IGF1R IGF1R PPP2R5C PPP2R5C PPP3CB PPP3CB MAP2K1 MAP2K1 CPEB3 CPEB3 CPEB2 CPEB2 MAPK14 MAPK14 ITPR3 ITPR3 PPP2R5E PPP2R5E PPP1CB PPP1CB RPS6KA2 RPS6KA2 ANAPC13 ANAPC13 INS INS RBX1 RBX1 PPP2R1A PPP2R1A PRKACA PRKACA YWHAE YWHAE ANAPC1 ANAPC1 YWHAH YWHAH CAMK2G CAMK2G IGF1 IGF1 CAMK2A CAMK2A BUB1 BUB1 CPEB1 CPEB1 PPP2R5B PPP2R5B MAPK11 MAPK11 SMC3 SMC3 CPEB4 CPEB4 PPP3R1 PPP3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBXO43F-box protein 43. (670 aa)
MAPK12Mitogen-activated protein kinase. (366 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CDC23Cell division cycle 23. (597 aa)
CDC25CCell division cycle 25C. (476 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (680 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. (939 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
F1PIN6_CANLFUncharacterized protein; Belongs to the calmodulin family. (364 aa)
CALML5Calmodulin like 5. (169 aa)
SGO1Shugoshin 1. (527 aa)
ANAPC11Anaphase promoting complex subunit 11. (458 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2628 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2108 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (197 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (373 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (399 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1051 aa)
SLKSTE20 like kinase. (1242 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PPP1CASerine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] (330 aa)
REC8REC8 meiotic recombination protein. (559 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (876 aa)
PLCZ1Phosphoinositide phospholipase C. (636 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (717 aa)
CDC27Cell division cycle 27. (831 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (771 aa)
STAG3Stromal antigen 3. (1232 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
MAD2L1HORMA domain-containing protein. (267 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (740 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (196 aa)
CCNB2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (397 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (907 aa)
CALML4Calmodulin like 4. (120 aa)
CALML6Calmodulin like 6. (156 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (1143 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PPP1CCSerine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] (499 aa)
CCNB1Uncharacterized protein; Belongs to the cyclin family. (425 aa)
LOC100682940Uncharacterized protein. (317 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PPP2CASerine/threonine-protein phosphatase. (310 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (245 aa)
FBXO5F-box protein 5. (447 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of prot [...] (1291 aa)
CDC26Cell division cycle 26. (85 aa)
PPP3CCSerine/threonine-protein phosphatase. (540 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (305 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
J9P9F2_CANLFCaMKII_AD domain-containing protein. (241 aa)
YWHAZ-214_3_3 domain-containing protein; Belongs to the 14-3-3 family. (252 aa)
SMC1BStructural maintenance of chromosomes protein. (1235 aa)
SPDYCSpeedy/RINGO cell cycle regulator family member C. (247 aa)
PTTG1Uncharacterized protein. (207 aa)
FBXW11F-box and WD repeat domain containing 11. (657 aa)
IGF1RTyrosine-protein kinase receptor. (1403 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (571 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (715 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (712 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2689 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (475 aa)
PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (337 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
ANAPC13Anaphase promoting complex subunit 13. (74 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa)
RBX1Ring-box 1. (108 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (590 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (314 aa)
ANAPC1Anaphase promoting complex subunit 1. (1973 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (266 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (611 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1245 aa)
CPEB1RRM domain-containing protein. (802 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (521 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
SMC3Structural maintenance of chromosomes protein. (1219 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (742 aa)
PPP3R1Uncharacterized protein. (169 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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