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| | UBR5 | Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | CUL7 | Cullin 7; Belongs to the cullin family. (1689 aa) |
| | UBE2M | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | UBA6 | Ubiquitin like modifier activating enzyme 6. (1980 aa) |
| | UBE2J1 | Ubiquitin conjugating enzyme E2 J1. (313 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | CBLC | Cbl proto-oncogene C. (497 aa) |
| | UBE2O | Ubiquitin conjugating enzyme E2 O. (1290 aa) |
| | VHL | Von Hippel-Lindau disease tumor suppressor; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (By similarity). (219 aa) |
| | LOC475563 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (176 aa) |
| | BIRC6 | Baculoviral IAP repeat containing 6. (4778 aa) |
| | ANAPC11 | Anaphase promoting complex subunit 11. (458 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (761 aa) |
| | UBOX5 | U-box domain containing 5. (541 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa) |
| | UBA2 | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (640 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (862 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (197 aa) |
| | UBE2W | UBIQUITIN_CONJUGAT_2 domain-containing protein. (208 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (754 aa) |
| | ELOC | Elongin C; Belongs to the SKP1 family. (112 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (598 aa) |
| | HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3. (1050 aa) |
| | CBLB | Cbl proto-oncogene B. (1004 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4929 aa) |
| | NHLRC1 | NHL repeat containing E3 ubiquitin protein ligase 1. (380 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (746 aa) |
| | AIRE | Autoimmune regulator. (583 aa) |
| | UBA7 | Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1008 aa) |
| | DET1 | DET1 partner of COP1 E3 ubiquitin ligase. (572 aa) |
| | RHOBTB1 | Rho related BTB domain containing 1. (698 aa) |
| | CDC27 | Cell division cycle 27. (831 aa) |
| | UBE2E3 | Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. (222 aa) |
| | UBA52 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (617 aa) |
| | SMURF1 | SMAD specific E3 ubiquitin protein ligase 1. (712 aa) |
| | PPIL2 | Peptidylprolyl isomerase like 2. (523 aa) |
| | UBE2K | Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa) |
| | NEDD4 | NEDD4 E3 ubiquitin protein ligase. (1323 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1140 aa) |
| | HUWE1 | HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4399 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa) |
| | UBE2Z | Ubiquitin conjugating enzyme E2 Z. (220 aa) |
| | HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4860 aa) |
| | TRIM37 | Tripartite motif containing 37. (973 aa) |
| | KEAP1 | Kelch like ECH associated protein 1. (624 aa) |
| | UBE2A | Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (329 aa) |
| | FBXO4 | F-box protein 4. (387 aa) |
| | SKP2 | S-phase kinase associated protein 2. (436 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (197 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (521 aa) |
| | ELOB | Elongin B. (115 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (1143 aa) |
| | UBE4B | Ubiquitination factor E4B. (1368 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | UBA3 | Ubiquitin like modifier activating enzyme 3. (472 aa) |
| | TRIM32 | Tripartite motif containing 32. (655 aa) |
| | UBE4A | Ubiquitination factor E4A. (1094 aa) |
| | XIAP | Baculoviral IAP-repeat containing protein 4. (493 aa) |
| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | UBE2E2 | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (192 aa) |
| | LOC607817 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | UBE2G2 | Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (165 aa) |
| | UBE2J2 | Ubiquitin conjugating enzyme E2 J2. (207 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (259 aa) |
| | CDC34 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (236 aa) |
| | LOC609637 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (155 aa) |
| | J9P3I6_CANLF | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa) |
| | UBE2N-3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | UBE2N-2 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | J9P6L9_CANLF | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | UBE2QL1 | Ubiquitin conjugating enzyme E2 Q family like 1. (161 aa) |
| | UBE2R2 | Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa) |
| | LOC607889 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | UBE2S | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (223 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1671 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (657 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (522 aa) |
| | CBL | Cbl proto-oncogene. (895 aa) |
| | KLHL13 | Kelch like family member 13. (668 aa) |
| | WWP1 | E3 ubiquitin-protein ligase. (947 aa) |
| | UBE2L6 | Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (190 aa) |
| | PIAS2 | Protein inhibitor of activated STAT 2. (612 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1921 aa) |
| | HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1074 aa) |
| | PML | Promyelocytic leukemia. (933 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (745 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (856 aa) |
| | BIRC3 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] (635 aa) |
| | UBE2L3 | Ubiquitin conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family. (212 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (464 aa) |
| | UBE2F | Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family. (185 aa) |
| | ANAPC13 | Anaphase promoting complex subunit 13. (74 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (1019 aa) |
| | PIAS3 | Protein inhibitor of activated STAT 3. (849 aa) |
| | MID1 | Midline 1. (667 aa) |
| | NEDD4L | NEDD4 like E3 ubiquitin protein ligase. (1015 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1973 aa) |
| | TRIP12 | Thyroid hormone receptor interactor 12. (2067 aa) |
| | SAE1 | SUMO1 activating enzyme subunit 1. (380 aa) |
| | UBE3B | Ubiquitin protein ligase E3B. (1132 aa) |
| | SYVN1 | Synoviolin 1. (816 aa) |
| | CUL5 | Cullin 5; Belongs to the cullin family. (794 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (919 aa) |
| | CUL2 | Cullin 2; Belongs to the cullin family. (757 aa) |
| | LOC476784 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (146 aa) |
| | UBE3C | Ubiquitin protein ligase E3C. (1273 aa) |
| | FBXW8 | F-box and WD repeat domain containing 8. (892 aa) |
| | WWP2 | E3 ubiquitin-protein ligase. (912 aa) |
| | SIAH1 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa) |
| | UBB | Ubiquitin B. (174 aa) |
| | UBE2G1 | Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (168 aa) |
| | PIAS1 | Protein inhibitor of activated STAT 1. (655 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (529 aa) |
| | KLHL9-2 | Uncharacterized protein. (150 aa) |
| | MGRN1 | Mahogunin ring finger 1. (588 aa) |
