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| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | DEPTOR | DEP domain containing MTOR interacting protein. (408 aa) |
| | LOC102156614 | Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (333 aa) |
| | CTSL3 | Uncharacterized protein; Belongs to the peptidase C1 family. (341 aa) |
| | DAPK1 | Death associated protein kinase 1. (1430 aa) |
| | C11H9orf72 | Chromosome 11 C9orf72 homolog. (481 aa) |
| | STX17 | Syntaxin 17; Belongs to the syntaxin family. (345 aa) |
| | RRAGD | Ras related GTP binding D. (385 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | RRAGC | Ras related GTP binding C. (539 aa) |
| | AKT1S1 | AKT1 substrate 1. (276 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) |
| | RAB33B | RAB33B, member RAS oncogene family. (219 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (557 aa) |
| | MTMR14 | Myotubularin related protein 14. (648 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2628 aa) |
| | PIK3R4 | Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa) |
| | IRS2 | Insulin receptor substrate 2. (1382 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (413 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (1004 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1113 aa) |
| | MRAS | Muscle RAS oncogene homolog. (208 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (221 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | VAMP8 | Vesicle associated membrane protein 8. (101 aa) |
| | CAMKK2 | Calcium/calmodulin dependent protein kinase kinase 2. (859 aa) |
| | RRAS2 | RAS related 2. (193 aa) |
| | PRKCD | Protein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of [...] (674 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | NRAS | Uncharacterized protein. (189 aa) |
| | CTSD | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. (410 aa) |
| | ATG3 | Autophagy-related protein 3. (312 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (975 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (491 aa) |
| | MTMR3 | Myotubularin related protein 3. (1062 aa) |
| | RUBCN | Rubicon autophagy regulator. (1014 aa) |
| | ATG4B | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (389 aa) |
| | PIK3R2 | Uncharacterized protein. (726 aa) |
| | ATG14 | Autophagy related 14. (510 aa) |
| | SNAP29 | Synaptosome associated protein 29. (258 aa) |
| | BECN2 | Beclin 2. (389 aa) |
| | RAB8A | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa) |
| | IGBP1 | Immunoglobulin binding protein 1. (416 aa) |
| | ZFYVE1 | Zinc finger FYVE-type containing 1. (788 aa) |
| | VMP1 | Vacuole membrane protein 1. (406 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa) |
| | ATG2B | Autophagy related 2B. (2077 aa) |
| | IRS4 | Insulin receptor substrate 4. (1275 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | ATG4C | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (532 aa) |
| | DAPK3 | Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa) |
| | TSC1 | TSC complex subunit 1. (1169 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa) |
| | MLST8 | MTOR associated protein, LST8 homolog. (326 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (310 aa) |
| | ATG13 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa) |
| | BNIP3 | BCL2 interacting protein 3. (354 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | DAPK2 | Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa) |
| | RAB39B | RAB39B, member RAS oncogene family. (210 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase. (510 aa) |
| | TSC2 | TSC complex subunit 2. (1783 aa) |
| | ATG16L2 | Autophagy related 16 like 2. (766 aa) |
| | NRBF2 | Nuclear receptor binding factor 2. (288 aa) |
| | GABARAPL2 | GABA type A receptor associated protein like 2. (117 aa) |
| | RAB1A | Ras-related protein Rab-1A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secreti [...] (205 aa) |
| | HRAS | Uncharacterized protein. (189 aa) |
| | ATG101 | Autophagy related 101. (269 aa) |
| | WDR41 | WD repeat domain 41. (573 aa) |
| | HMGB1 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (240 aa) |
| | TANK | TRAF family member associated NFKB activator. (509 aa) |
| | ATG2A | Autophagy related 2A. (1936 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (606 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1403 aa) |
| | RRAS | RAS related. (293 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa) |
| | BECN1 | Beclin 1. (471 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | TBK1 | TANK binding kinase 1. (772 aa) |
| | ULK2 | Unc-51 like autophagy activating kinase 2. (1081 aa) |
| | RHEB | Ras homolog, mTORC1 binding. (232 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (573 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa) |
| | GABARAPL1 | GABA type A receptor associated protein like 1. (142 aa) |
| | ATG16L1 | Autophagy related 16 like 1. (623 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (551 aa) |
| | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa) |
| | ATG4A | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (460 aa) |
| | ATG9A | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (928 aa) |
| | ATG7 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (726 aa) |
| | ALKAL1 | RB1 inducible coiled-coil 1. (1610 aa) |
| | SUPT20H | SPT20 homolog, SAGA complex component. (859 aa) |
| | CTSB | Cathepsin B; Belongs to the peptidase C1 family. (404 aa) |
| | SH3GLB1 | SH3 domain containing GRB2 like, endophilin B1. (369 aa) |
| | AMBRA1 | Autophagy and beclin 1 regulator 1. (1301 aa) |
| | WIPI1 | WD repeat domain, phosphoinositide interacting 1. (624 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | RRAGA | Ras related GTP binding A. (595 aa) |
| | HIF1A | Uncharacterized protein. (823 aa) |
| | SQSTM1 | Sequestosome 1. (551 aa) |
| | RAB7B | RAB7B, member RAS oncogene family. (222 aa) |
