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| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (340 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (680 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1483 aa) |
| | AKT1S1 | AKT1 substrate 1. (276 aa) |
| | RAB14 | RAB14, member RAS oncogene family. (215 aa) |
| | FOXO3 | Forkhead box O3. (671 aa) |
| | GYS1 | Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (735 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | RAB10 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (200 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | LIPE | Lipase E, hormone sensitive type. (1097 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (545 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (597 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (529 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (557 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) |
| | FOXO1 | Forkhead box O1. (654 aa) |
| | FASN | Fatty acid synthase. (2478 aa) |
| | IRS2 | Insulin receptor substrate 2. (1382 aa) |
| | EIF4EBP1 | Eukaryotic translation initiation factor 4E binding protein 1. (118 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (1004 aa) |
| | PPP2R3A | Protein phosphatase 2 regulatory subunit B''alpha. (1152 aa) |
| | RAB2A | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. (232 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | CAMKK2 | Calcium/calmodulin dependent protein kinase kinase 2. (859 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa) |
| | PFKM | ATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (853 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (519 aa) |
| | CAB39 | Calcium binding protein 39. (341 aa) |
| | CPT1A | Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (773 aa) |
| | PFKL | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa) |
| | ACACB | Acetyl-CoA carboxylase beta. (2431 aa) |
| | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (526 aa) |
| | G6PC2 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (794 aa) |
| | GYS2 | Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa) |
| | STRADB | STE20 related adaptor beta. (414 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa) |
| | SIRT1 | Sirtuin 1. (745 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (771 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (433 aa) |
| | G6PC | Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity). (357 aa) |
| | PIK3R2 | Uncharacterized protein. (726 aa) |
| | RAB8A | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa) |
| | CRTC2 | CREB regulated transcription coactivator 2. (694 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | EEF2K | Eukaryotic elongation factor 2 kinase. (725 aa) |
| | IRS4 | Insulin receptor substrate 4. (1275 aa) |
| | ACACA | Acetyl-CoA carboxylase alpha. (2383 aa) |
| | ELAVL1 | ELAV-like protein; Belongs to the RRM elav family. (326 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | SREBF1 | Sterol regulatory element binding transcription factor 1. (1147 aa) |
| | LEPR | Leptin receptor. (1166 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (532 aa) |
| | EEF2 | Eukaryotic translation elongation factor 2. (858 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa) |
| | TSC1 | TSC complex subunit 1. (1169 aa) |
| | MLYCD | Malonyl-CoA decarboxylase. (498 aa) |
| | PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (516 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (310 aa) |
| | RAB11B | RAB11B, member RAS oncogene family. (218 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase. (510 aa) |
| | TBC1D1 | TBC1 domain family member 1. (1327 aa) |
| | TSC2 | TSC complex subunit 2. (1783 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1406 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (427 aa) |
| | SCD | Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (355 aa) |
| | SCD5 | Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (322 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (382 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1403 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (571 aa) |
| | CPT1C | Carnitine palmitoyltransferase 1C. (914 aa) |
| | FBP1 | Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (363 aa) |
| | STRADA | STE20 related adaptor alpha. (431 aa) |
| | ADIPOR2 | Adiponectin receptor 2. (559 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (525 aa) |
| | HNF4A | Hepatocyte nuclear factor 4 alpha. (484 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (275 aa) |
| | RHEB | Ras homolog, mTORC1 binding. (232 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (475 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (891 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (573 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (590 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (551 aa) |
| | PFKP | Phosphofructokinase, platelet. (870 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa) |
| | CREB5 | cAMP responsive element binding protein 5. (552 aa) |
| | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (537 aa) |
| | ADRA1A | Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). (466 aa) |
| | HMGCR | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (935 aa) |
| | PPP2R3B | Protein phosphatase 2 regulatory subunit B''beta. (695 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (521 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa) |
| | SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (553 aa) |
| | CAB39L | Calcium binding protein 39 like. (352 aa) |
