STRINGSTRING
KIF3A KIF3A CUL1 CUL1 GLI3 GLI3 PTCH2 PTCH2 MEGF8 MEGF8 GLI2 GLI2 CSNK1D CSNK1D HHIP HHIP BTRC BTRC SUFU SUFU CUL3 CUL3 CDON CDON GRK2 GRK2 KIF7 KIF7 LRP2 LRP2 SMURF1 SMURF1 GPR161 GPR161 CCND2 CCND2 EVC2 EVC2 EVC EVC SPOP SPOP PPIB PPIB MOSMO MOSMO PRKACB PRKACB GAS1 GAS1 GSK3B GSK3B SPOPL SPOPL FBXW11 FBXW11 BOC BOC SMURF2 SMURF2 SHH SHH CSNK1A1 CSNK1A1 ARRB2 ARRB2 PRKACA PRKACA PTCH1 PTCH1 ARRB1 ARRB1 CSNK1G3 CSNK1G3 CSNK1E CSNK1E GRK3 GRK3 SMO SMO GLI1 GLI1 CCND1 CCND1 CSNK1G2 CSNK1G2 MGRN1 MGRN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
GLI3GLI family zinc finger 3. (1590 aa)
PTCH2Patched 2. (1207 aa)
MEGF8Multiple EGF like domains 8. (439 aa)
GLI2GLI family zinc finger 2. (1547 aa)
CSNK1DCasein kinase 1 delta. (439 aa)
HHIPHedgehog interacting protein. (682 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
CUL3Cullin 3; Belongs to the cullin family. (746 aa)
CDONCell adhesion associated, oncogene regulated. (1235 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1402 aa)
LRP2LDL receptor related protein 2. (4645 aa)
SMURF1SMAD specific E3 ubiquitin protein ligase 1. (712 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (549 aa)
CCND2Cyclin D2; Belongs to the cyclin family. (328 aa)
EVC2EvC ciliary complex subunit 2. (1346 aa)
EVCEvC ciliary complex subunit 1. (1019 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
PPIBCasein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (476 aa)
MOSMOModulator of smoothened. (167 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
GAS1Growth arrest specific 1. (385 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
SPOPLSpeckle type BTB/POZ protein like. (392 aa)
FBXW11F-box and WD repeat domain containing 11. (657 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1121 aa)
SMURF2E3 ubiquitin-protein ligase. (745 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (593 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (415 aa)
ARRB2Arrestin beta 2. (678 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)
PTCH1Patched 1. (1449 aa)
ARRB1Arrestin beta 1. (542 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (456 aa)
CSNK1ECasein kinase 1 epsilon; Belongs to the protein kinase superfamily. (431 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (672 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (760 aa)
GLI1GLI family zinc finger 1. (1139 aa)
CCND1G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa)
CSNK1G2Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (482 aa)
MGRN1Mahogunin ring finger 1. (588 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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