STRINGSTRING
INHBC INHBC IFNG IFNG TNF TNF SKP1 SKP1 MYC MYC SMAD5 SMAD5 EP300 EP300 BMP5 BMP5 LOC100855618 LOC100855618 CUL1 CUL1 INHBA INHBA INHBB-2 INHBB-2 B9D2 B9D2 ACVR2B ACVR2B DCN DCN SMAD9 SMAD9 PPP2CB PPP2CB SP1 SP1 ID1 ID1 HAMP HAMP SMAD1 SMAD1 GDF5 GDF5 GREM1 GREM1 E2F5 E2F5 THBS1 THBS1 ZFYVE16 ZFYVE16 FMOD FMOD ID4 ID4 TGFB2 TGFB2 RGMA RGMA HJV HJV ID3 ID3 PPP2R1B PPP2R1B FBN1 FBN1 BMP4 BMP4 SMURF1 SMURF1 GREM2 GREM2 BMPR1A BMPR1A LOC490387 LOC490387 TGFB3 TGFB3 SMAD6 SMAD6 SMAD3 SMAD3 THSD4 THSD4 RPS6KB1 RPS6KB1 TGIF1 TGIF1 SMAD7 SMAD7 RHOA RHOA MAPK1 MAPK1 PPP2CA PPP2CA BMPR2 BMPR2 CREBBP CREBBP RPS6KB2 RPS6KB2 E2F4 E2F4 BMP6 BMP6 NODAL NODAL GDF7 GDF7 RGMB RGMB TGFBR1 TGFBR1 BMP7 BMP7 CHRD CHRD TGIF2 TGIF2 BMPR1B BMPR1B ACVR1 ACVR1 BMP2 BMP2 NEO1 NEO1 ZFYVE9 ZFYVE9 SMURF2 SMURF2 FST FST ROCK1 ROCK1 RBX1 RBX1 LTBP1 LTBP1 SMAD4 SMAD4 AMHR2 AMHR2 PPP2R1A PPP2R1A ACVR2A ACVR2A PITX2 PITX2 NBL1 NBL1 TGFBR2 TGFBR2 TFDP1 TFDP1 BAMBI BAMBI SMAD2 SMAD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INHBCInhibin subunit beta C. (351 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
EP300E1A binding protein p300. (2308 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
LOC100855618TGF_BETA_2 domain-containing protein. (297 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
INHBAInhibin subunit beta A. (424 aa)
INHBB-2Inhibin subunit beta B. (131 aa)
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SP1Sp1 transcription factor. (782 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
HAMPHepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Belongs to the hepcidin family. (85 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GDF5Growth differentiation factor 5. (499 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (230 aa)
E2F5E2F transcription factor 5. (184 aa)
THBS1Thrombospondin 1. (1456 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1480 aa)
FMODFibromodulin. (376 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (224 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (422 aa)
HJVHemojuvelin BMP co-receptor. (469 aa)
ID3DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the [...] (119 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (771 aa)
FBN1Uncharacterized protein. (2871 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
SMURF1SMAD specific E3 ubiquitin protein ligase 1. (712 aa)
GREM2Gremlin. (171 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC490387Left-right determination factor. (367 aa)
TGFB3Transforming growth factor beta 3. (457 aa)
SMAD6Mothers against decapentaplegic homolog. (499 aa)
SMAD3Mothers against decapentaplegic homolog. (611 aa)
THSD4Thrombospondin type 1 domain containing 4. (658 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
TGIF1TGFB induced factor homeobox 1. (272 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PPP2CASerine/threonine-protein phosphatase. (310 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
CREBBPCREB binding protein. (2442 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (510 aa)
E2F4E2F transcription factor 4. (471 aa)
BMP6Bone morphogenetic protein 6. (335 aa)
NODALNodal growth differentiation factor. (378 aa)
GDF7TGF_BETA_2 domain-containing protein. (755 aa)
RGMBRGM_N domain-containing protein. (233 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
BMP7Bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). (653 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (959 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
BMP2Bone morphogenetic protein 2. (436 aa)
NEO1Neogenin 1. (1551 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1438 aa)
SMURF2E3 ubiquitin-protein ligase. (745 aa)
FSTFollistatin. (237 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1381 aa)
RBX1Ring-box 1. (108 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1598 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (565 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (590 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (735 aa)
PITX2Paired like homeodomain 2. (458 aa)
NBL1NBL1, DAN family BMP antagonist. (240 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
TFDP1Transcription factor. (437 aa)
BAMBIBMP and activin membrane bound inhibitor. (293 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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