STRINGSTRING
PARD6G PARD6G DCC DCC SRGAP1 SRGAP1 PLXNA2 PLXNA2 RAC2 RAC2 LRRC4 LRRC4 NCK2 NCK2 SEMA4C SEMA4C EPHA5 EPHA5 EPHA7 EPHA7 EPHA1 EPHA1 PARD3 PARD3 EPHB6 EPHB6 ITGB1 ITGB1 PIK3R3 PIK3R3 DPYSL5 DPYSL5 RAF1 RAF1 PAK3 PAK3 SRGAP3 SRGAP3 PAK5 PAK5 RAC3 RAC3 TRPC4 TRPC4 SEMA3D SEMA3D PLXNC1 PLXNC1 SEMA3A SEMA3A UNC5D UNC5D SEMA3C SEMA3C LRRC4C LRRC4C EPHB1 EPHB1 NCK1 NCK1 PIK3CB PIK3CB PIK3R1 PIK3R1 TRPC1 TRPC1 FZD3 FZD3 MYL9 MYL9 DPYSL2 DPYSL2 RND1 RND1 EPHA3 EPHA3 PTPN11 PTPN11 SLIT1 SLIT1 PAK6 PAK6 EPHA6 EPHA6 SEMA3G SEMA3G NRAS NRAS SEMA4G SEMA4G UNC5C UNC5C PPP3CA PPP3CA SEMA3F SEMA3F RGMA RGMA SSH1 SSH1 PRKCA PRKCA F1Q1C8_CANLF F1Q1C8_CANLF ABLIM1 ABLIM1 NGEF NGEF NFATC2 NFATC2 SSH3 SSH3 RHOD RHOD ARHGEF12 ARHGEF12 SEMA4B SEMA4B CAMK2D CAMK2D FES FES LIMK1 LIMK1 PLXNB1 PLXNB1 PDK1 PDK1 EPHB3 EPHB3 SEMA6D SEMA6D EPHA8 EPHA8 PIK3R2 PIK3R2 WNT5B WNT5B EPHA4 EPHA4 EPHA2 EPHA2 GNAI1 GNAI1 MYL5 MYL5 SEMA4A SEMA4A EFNA1 EFNA1 EFNA3 EFNA3 NTN1 NTN1 SEMA7A SEMA7A TRPC5 TRPC5 SEMA6B SEMA6B PLXNB3 PLXNB3 NTN3 NTN3 PRKCZ PRKCZ PLXNA3 PLXNA3 PIK3CD PIK3CD GNAI3 GNAI3 NTNG2 NTNG2 ABL1 ABL1 PLCG2 PLCG2 RHOA RHOA MAPK1 MAPK1 BMPR2 BMPR2 GNAI2 GNAI2 ILK ILK GSK3B GSK3B CXCL12 CXCL12 SSH2 SSH2 GDF7 GDF7 NFATC4 NFATC4 PARD6A PARD6A HRAS HRAS WNT5A WNT5A SEMA3B SEMA3B PPP3CC PPP3CC BMP7 BMP7 MET MET LOC478801 LOC478801 J9P9F2_CANLF J9P9F2_CANLF TRPC3 TRPC3 UNC5A UNC5A PPP3CB PPP3CB BOC BOC ABLIM3 ABLIM3 PAK1 PAK1 RRAS RRAS SRC SRC BMPR1B BMPR1B EFNA4 EFNA4 PLCG1 PLCG1 PIK3CA PIK3CA NEO1 NEO1 ROBO3 ROBO3 SEMA4D SEMA4D ROCK1 ROCK1 SEMA6C SEMA6C SHH SHH RASA1 RASA1 SLIT3 SLIT3 PTK2 PTK2 RYK RYK EFNB2 EFNB2 NFATC3 NFATC3 SEMA3E SEMA3E PTCH1 PTCH1 SRGAP2 SRGAP2 CDK5 CDK5 CAMK2G CAMK2G UNC5B UNC5B CAMK2A CAMK2A MYL12B MYL12B SLIT2 SLIT2 SEMA5A SEMA5A SMO SMO CDC42-2 CDC42-2 EFNB1 EFNB1 SEMA6A SEMA6A L1CAM L1CAM ENAH ENAH ROBO1 ROBO1 NRP1 NRP1 EPHB4 EPHB4 NTN4 NTN4 PLXNA4 PLXNA4 PAK2 PAK2 PPP3R1 PPP3R1 ABLIM2 ABLIM2 CFL1 CFL1 ROCK2 ROCK2 SEMA4F SEMA4F CFL2 CFL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARD6GPar-6 family cell polarity regulator gamma. (385 aa)
DCCDCC netrin 1 receptor. (1416 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1086 aa)
PLXNA2Plexin A2. (1909 aa)
RAC2Rac family small GTPase 2. (192 aa)
LRRC4Leucine rich repeat containing 4. (650 aa)
NCK2Cytoplasmic protein. (380 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
EPHA5EPH receptor A5. (978 aa)
EPHA7EPH receptor A7. (998 aa)
EPHA1EPH receptor A1. (976 aa)
PARD3Par-3 family cell polarity regulator. (1258 aa)
EPHB6EPH receptor B6. (972 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (820 aa)
PIK3R3Uncharacterized protein. (461 aa)
DPYSL5Dihydropyrimidinase like 5. (564 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PAK3P21 (RAC1) activated kinase 3. (583 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1099 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
RAC3Uncharacterized protein. (210 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
PLXNC1Plexin C1. (1594 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
UNC5DUnc-5 netrin receptor D. (947 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
LRRC4CLeucine rich repeat containing 4C. (639 aa)
EPHB1EPH receptor B1. (984 aa)
NCK1Cytoplasmic protein. (377 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
MYL9Myosin light chain 9. (172 aa)
DPYSL2Dihydropyrimidinase like 2. (677 aa)
RND1Rho family GTPase 1. (290 aa)
EPHA3EPH receptor A3. (957 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
EPHA6EPH receptor A6; Belongs to the protein kinase superfamily. Tyr protein kinase family. (320 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (772 aa)
NRASUncharacterized protein. (189 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (840 aa)
UNC5CUnc-5 netrin receptor C. (950 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (786 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (422 aa)
SSH1Slingshot protein phosphatase 1. (1056 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
F1Q1C8_CANLFADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (207 aa)
ABLIM1Actin binding LIM protein 1. (834 aa)
NGEFNeuronal guanine nucleotide exchange factor. (675 aa)
NFATC2Nuclear factor of activated T cells 2. (1086 aa)
SSH3Slingshot protein phosphatase 3. (649 aa)
RHODRas homolog family member D. (210 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1543 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (833 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (820 aa)
LIMK1LIM domain kinase 1. (761 aa)
PLXNB1Plexin B1. (2137 aa)
PDK1Protein-serine/threonine kinase. (418 aa)
EPHB3EPH receptor B3. (1012 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
EPHA8EPH receptor A8. (1000 aa)
PIK3R2Uncharacterized protein. (726 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
EPHA4EPH receptor A4. (955 aa)
EPHA2EPH receptor A2. (1121 aa)
GNAI1G protein subunit alpha i1. (337 aa)
MYL5Myosin light chain 5. (289 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (805 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (238 aa)
NTN1Netrin 1. (577 aa)
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (632 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (975 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (745 aa)
PLXNB3Plexin B3. (1869 aa)
NTN3Netrin 3. (577 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
PLXNA3Plexin A3. (1872 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
GNAI3G protein subunit alpha i3. (354 aa)
NTNG2Netrin G2. (522 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). (355 aa)
ILKIntegrin linked kinase. (452 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (117 aa)
SSH2Slingshot protein phosphatase 2. (1421 aa)
GDF7TGF_BETA_2 domain-containing protein. (755 aa)
NFATC4Nuclear factor of activated T cells 4. (946 aa)
PARD6APar-6 family cell polarity regulator alpha. (514 aa)
HRASUncharacterized protein. (189 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (748 aa)
PPP3CCSerine/threonine-protein phosphatase. (540 aa)
BMP7Bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). (653 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1421 aa)
LOC478801Protein-serine/threonine kinase. (155 aa)
J9P9F2_CANLFCaMKII_AD domain-containing protein. (241 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (925 aa)
UNC5AUnc-5 netrin receptor A. (898 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1121 aa)
ABLIM3Actin binding LIM protein family member 3. (691 aa)
PAK1Non-specific serine/threonine protein kinase. (552 aa)
RRASRAS related. (293 aa)
SRCTyrosine-protein kinase. (553 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
EFNA4ADAM metallopeptidase domain 15; Belongs to the ephrin family. (1017 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NEO1Neogenin 1. (1551 aa)
ROBO3Roundabout guidance receptor 3. (1421 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (1067 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1381 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (963 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (593 aa)
RASA1RAS p21 protein activator 1. (1030 aa)
SLIT3Slit guidance ligand 3. (1487 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
RYKReceptor like tyrosine kinase. (635 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (725 aa)
PTCH1Patched 1. (1449 aa)
SRGAP2Uncharacterized protein. (1078 aa)
CDK5Cyclin dependent kinase 5. (390 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (611 aa)
UNC5BUnc-5 netrin receptor B. (1005 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
MYL12BUncharacterized protein. (259 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
SEMA5ASemaphorin 5A. (1073 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (760 aa)
CDC42-2Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
EFNB1Ephrin B1. (377 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
L1CAML1 cell adhesion molecule. (1431 aa)
ENAHENAH actin regulator. (835 aa)
ROBO1Roundabout guidance receptor 1. (1691 aa)
NRP1Neuropilin 1. (1029 aa)
EPHB4EPH receptor B4. (987 aa)
NTN4Netrin 4. (649 aa)
PLXNA4Plexin A4. (1939 aa)
PAK2Non-specific serine/threonine protein kinase. (718 aa)
PPP3R1Uncharacterized protein. (169 aa)
ABLIM2Actin binding LIM protein family member 2. (724 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (200 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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