STRINGSTRING
MAPK12 MAPK12 MAPK13 MAPK13 RAC2 RAC2 KDR KDR PRKCG PRKCG SPHK2 SPHK2 PIK3R3 PIK3R3 RAF1 RAF1 SPHK1 SPHK1 AKT2 AKT2 RAC3 RAC3 PIK3CB PIK3CB PIK3R1 PIK3R1 NRAS NRAS PLA2G4D PLA2G4D PLA2G4F PLA2G4F MAPKAPK3 MAPKAPK3 PPP3CA PPP3CA PRKCA PRKCA NFATC2 NFATC2 HSPB1 HSPB1 PTGS2 PTGS2 PLA2G4A PLA2G4A PIK3R2 PIK3R2 AKT3 AKT3 PRKCB PRKCB AKT1 AKT1 SHC2 SHC2 PIK3CD PIK3CD PLCG2 PLCG2 MAPK1 MAPK1 SH2D2A SH2D2A BAD BAD HRAS HRAS PPP3CC PPP3CC JMJD7 JMJD7 VEGFA VEGFA MAP2K2 MAP2K2 PPP3CB PPP3CB SRC SRC MAP2K1 MAP2K1 PLCG1 PLCG1 MAPK14 MAPK14 PIK3CA PIK3CA PXN-2 PXN-2 PTK2 PTK2 PLA2G4E PLA2G4E CDC42-2 CDC42-2 NOS3 NOS3 MAPK11 MAPK11 CASP9 CASP9 PPP3R1 PPP3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK12Mitogen-activated protein kinase. (366 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
RAC2Rac family small GTPase 2. (192 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SPHK2Sphingosine kinase 2. (733 aa)
PIK3R3Uncharacterized protein. (461 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SPHK1Sphingosine kinase 1. (487 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
RAC3Uncharacterized protein. (210 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
NRASUncharacterized protein. (189 aa)
PLA2G4DPhospholipase A2. (812 aa)
PLA2G4FPhospholipase A2. (870 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (381 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
NFATC2Nuclear factor of activated T cells 2. (1086 aa)
HSPB1Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. (206 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PLA2G4APhospholipase A2. (749 aa)
PIK3R2Uncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SHC2Uncharacterized protein. (636 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SH2D2ASH2 domain containing 2A. (438 aa)
BADBCL2 associated agonist of cell death. (167 aa)
HRASUncharacterized protein. (189 aa)
PPP3CCSerine/threonine-protein phosphatase. (540 aa)
JMJD7Phospholipase A2. (841 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (495 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
SRCTyrosine-protein kinase. (553 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PXN-2Uncharacterized protein. (258 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
PLA2G4EPhospholipase A2. (891 aa)
CDC42-2Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1256 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (489 aa)
PPP3R1Uncharacterized protein. (169 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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