STRINGSTRING
TNFRSF11A TNFRSF11A STAT2 STAT2 IFNGR1 IFNGR1 TAB2 TAB2 IFNG IFNG TNF TNF MAPK12 MAPK12 TNFRSF11B TNFRSF11B TAB1 TAB1 MAPK13 MAPK13 NCF4 NCF4 IFNB1 IFNB1 TEC TEC FHL2 FHL2 MAP3K7 MAP3K7 PIK3R3 PIK3R3 RELB RELB TNFSF11 TNFSF11 GAB2 GAB2 PPARG PPARG B9D2 B9D2 AKT2 AKT2 SIRPA SIRPA TRAF6 TRAF6 IL1B IL1B PIK3CB PIK3CB PIK3R1 PIK3R1 SPI1 SPI1 LOC609830 LOC609830 MAPK10 MAPK10 CHUK CHUK NFKB2 NFKB2 PPP3CA PPP3CA LCK LCK TGFB2 TGFB2 FCGR1A FCGR1A NFATC2 NFATC2 CTSK CTSK FOSL1 FOSL1 RELA RELA NFKBIA NFKBIA CREB1 CREB1 MAP3K14 MAP3K14 PIK3R2 PIK3R2 AKT3 AKT3 FOS FOS ACP5 ACP5 AKT1 AKT1 SOCS1 SOCS1 TRAF2 TRAF2 IKBKG IKBKG PIK3CD PIK3CD PLCG2 PLCG2 MAPK1 MAPK1 JUND JUND NFATC1 NFATC1 ITGB3 ITGB3 LOC609523 LOC609523 JUNB JUNB LOC609123 LOC609123 IL1A IL1A JAK1 JAK1 LCP2 LCP2 J9NSS9_CANLF J9NSS9_CANLF TGFBR1 TGFBR1 PPP3CC PPP3CC BTK BTK PPP3CB PPP3CB IFNGR2 IFNGR2 ENSCAFP00000045270 ENSCAFP00000045270 MAP2K1 MAP2K1 IL1R1 IL1R1 CALCR CALCR MAPK8 MAPK8 IKBKB IKBKB MITF MITF MAPK14 MAPK14 PIK3CA PIK3CA STAT1 STAT1 GRB2 GRB2 IFNAR1 IFNAR1 TYK2 TYK2 BLNK BLNK ENSCAFP00000052399 ENSCAFP00000052399 LOC477182 LOC477182 CSF1R CSF1R LOC611446 LOC611446 SYK SYK NFKB1 NFKB1 OSCAR OSCAR LOC487739 LOC487739 IFNAR2 IFNAR2 LOC478984 LOC478984 CYLD CYLD MAP2K6 MAP2K6 CSF1 CSF1 TNFRSF1A TNFRSF1A MAPK11 MAPK11 TGFBR2 TGFBR2 MAPK9 MAPK9 FOSL2 FOSL2 PPP3R1 PPP3R1 LOC484309 LOC484309 SQSTM1 SQSTM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFRSF11ATNF receptor superfamily member 11a. (648 aa)
STAT2Signal transducer and activator of transcription. (844 aa)
IFNGR1Interferon gamma receptor 1. (475 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MAPK12Mitogen-activated protein kinase. (366 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
IFNB1Interferon-beta. (186 aa)
TECTyrosine-protein kinase. (631 aa)
FHL2Four and a half LIM domains 2. (279 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PIK3R3Uncharacterized protein. (461 aa)
RELBRELB proto-oncogene, NF-kB subunit. (560 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (512 aa)
GAB2GRB2 associated binding protein 2. (663 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (529 aa)
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
SIRPAUncharacterized protein. (506 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
SPI1Spi-1 proto-oncogene. (358 aa)
LOC609830Uncharacterized protein. (569 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LCKTyrosine-protein kinase. (509 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FCGR1AUncharacterized protein. (428 aa)
NFATC2Nuclear factor of activated T cells 2. (1086 aa)
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (446 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (268 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
PIK3R2Uncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (343 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SOCS1Suppressor of cytokine signaling 1. (197 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (539 aa)
NFATC1Nuclear factor of activated T cells 1. (923 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (919 aa)
LOC609523Uncharacterized protein. (408 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
LOC609123Uncharacterized protein. (451 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (273 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
J9NSS9_CANLFUncharacterized protein. (383 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
PPP3CCSerine/threonine-protein phosphatase. (540 aa)
BTKTyrosine-protein kinase. (687 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
IFNGR2Uncharacterized protein. (435 aa)
ENSCAFP00000045270Ig-like domain-containing protein. (169 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
IL1R1Interleukin 1 receptor type 1. (629 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MITFMelanocyte inducing transcription factor. (533 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
STAT1Signal transducer and activator of transcription. (774 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
IFNAR1Uncharacterized protein. (572 aa)
TYK2Tyrosine-protein kinase. (1173 aa)
BLNKB cell linker. (483 aa)
ENSCAFP00000052399Uncharacterized protein. (383 aa)
LOC477182Uncharacterized protein. (465 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa)
LOC611446Uncharacterized protein. (651 aa)
SYKTyrosine-protein kinase. (699 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
OSCAROsteoclast associated Ig-like receptor. (265 aa)
LOC487739Uncharacterized protein. (363 aa)
IFNAR2Uncharacterized protein. (522 aa)
LOC478984Uncharacterized protein. (286 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (972 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
CSF1Colony stimulating factor 1. (587 aa)
TNFRSF1ATNF receptor superfamily member 1A. (752 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (345 aa)
PPP3R1Uncharacterized protein. (169 aa)
LOC484309Uncharacterized protein. (552 aa)
SQSTM1Sequestosome 1. (551 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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