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| | PARD6G | Par-6 family cell polarity regulator gamma. (385 aa) |
| | STK3 | Serine/threonine kinase 3. (491 aa) |
| | FZD6 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (712 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (651 aa) |
| | BMP5 | Bone morphogenetic protein 5. (454 aa) |
| | MOB1B | MOB kinase activator 1B. (216 aa) |
| | RASSF6 | Ras association domain family member 6. (335 aa) |
| | LOC100855618 | TGF_BETA_2 domain-containing protein. (297 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (280 aa) |
| | PARD3 | Par-3 family cell polarity regulator. (1258 aa) |
| | LLGL2 | LLGL scribble cell polarity complex component 2. (1022 aa) |
| | GLI2 | GLI family zinc finger 2. (1547 aa) |
| | B9D2 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | CTNNB1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (744 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | CSNK1D | Casein kinase 1 delta. (439 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | ID1 | Inhibitor of DNA binding 1, HLH protein. (154 aa) |
| | LATS2 | Non-specific serine/threonine protein kinase. (1085 aa) |
| | SMAD1 | Mothers against decapentaplegic homolog. (465 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (588 aa) |
| | GDF5 | Growth differentiation factor 5. (499 aa) |
| | TEAD1 | TEA domain transcription factor 1. (498 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | WWTR1 | WW domain containing transcription regulator 1. (400 aa) |
| | MOB1A | MOB kinase activator 1A. (216 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | RASSF1 | Ras association domain family member 1. (344 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | AJUBA | Ajuba LIM protein. (870 aa) |
| | CRB1 | Crumbs cell polarity complex component 1. (1433 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] (330 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (718 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (594 aa) |
| | CTNNA3 | Catenin alpha 3. (895 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa) |
| | SERPINE1 | Serpin family E member 1; Belongs to the serpin family. (449 aa) |
| | LIMD1 | LIM domains containing 1. (655 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (771 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (433 aa) |
| | FRMD6 | FERM domain containing 6. (622 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa) |
| | BMP4 | TGF_BETA_2 domain-containing protein. (409 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (617 aa) |
| | CCND2 | Cyclin D2; Belongs to the cyclin family. (328 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | MPP5 | MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells. Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface. Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebell [...] (675 aa) |
| | TP53BP2 | Tumor protein p53 binding protein 2. (1200 aa) |
| | TGFB3 | Transforming growth factor beta 3. (457 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (611 aa) |
| | AMOT | Angiomotin. (1085 aa) |
| | LLGL1 | LLGL scribble cell polarity complex component 1. (1201 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (431 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (700 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2072 aa) |
| | LOC489647 | Uncharacterized protein. (513 aa) |
| | CDH1 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. (885 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] (499 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (910 aa) |
| | NF2 | Neurofibromin 2. (597 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (310 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (245 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | DLG3-2 | SH3 domain-containing protein. (185 aa) |
| | FRMD1 | Uncharacterized protein. (232 aa) |
| | BMP6 | Bone morphogenetic protein 6. (335 aa) |
| | TEAD2 | TEA domain transcription factor 2. (450 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (339 aa) |
| | GDF7 | TGF_BETA_2 domain-containing protein. (755 aa) |
| | YAP1 | Yes associated protein 1. (325 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa) |
| | AREG | Amphiregulin. (275 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (565 aa) |
| | PARD6A | Par-6 family cell polarity regulator alpha. (514 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (427 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | BMP7 | Bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). (653 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1127 aa) |
| | YWHAZ-2 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (252 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (673 aa) |
| | TCF7 | Transcription factor 7. (484 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (657 aa) |
| | BMPR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa) |
| | TEAD4 | Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (480 aa) |
| | BIRC5 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (533 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (471 aa) |
| | DLG2 | Discs large MAGUK scaffold protein 2. (1012 aa) |
| | BMP2 | Bone morphogenetic protein 2. (436 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (525 aa) |
| | APC | APC regulator of WNT signaling pathway. (2851 aa) |
| | BIRC3 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] (635 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (337 aa) |
| | SCRIB | Scribble planar cell polarity protein. (1568 aa) |
| | DLG5 | Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1940 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (619 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (590 aa) |
| | CCN2 | Cellular communication network factor 2. (388 aa) |
| | CRB2 | Crumbs cell polarity complex component 2. (1285 aa) |
| | BBC3 | Uncharacterized protein. (293 aa) |
| | AXIN1 | Axin 1. (992 aa) |
| | CTNNA1 | Catenin alpha 1. (918 aa) |
| | PATJ | PATJ crumbs cell polarity complex component. (1884 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (314 aa) |
| | TEAD3 | TEA domain transcription factor 3. (614 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (266 aa) |
| | CSNK1E | Casein kinase 1 epsilon; Belongs to the protein kinase superfamily. (431 aa) |
| | CTNNA2 | Catenin alpha 2. (953 aa) |
| | DLG4 | Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (744 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (380 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa) |
| | WWC1 | WW and C2 domain containing 1. (1101 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa) |
| | SAV1 | Salvador family WW domain containing protein 1. (384 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | AFM | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. (725 aa) |
