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| | RAP1B | RAP1B, member of RAS oncogene family. (184 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] (1099 aa) |
| | TNXB | Tenascin XB. (3966 aa) |
| | PARVG | Parvin gamma. (330 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | FLNC | Filamin C. (2720 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (543 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa) |
| | TLN1 | Talin 1. (2558 aa) |
| | SHC3 | SHC adaptor protein 3. (458 aa) |
| | COL9A1 | Collagen type IX alpha 1 chain. (921 aa) |
| | PPP1R12C | Protein phosphatase 1 regulatory subunit. (758 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | COL9A2 | Collagen type IX alpha 2 chain. (664 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1141 aa) |
| | ZYX | Zyxin. (411 aa) |
| | MYLK3 | Myosin light chain kinase 3. (850 aa) |
| | ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (820 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | ITGA8 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (993 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | PAK3 | P21 (RAC1) activated kinase 3. (583 aa) |
| | CTNNB1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (744 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (557 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (209 aa) |
| | PAK5 | Non-specific serine/threonine protein kinase. (719 aa) |
| | ACTN4 | Actinin alpha 4. (1163 aa) |
| | RAC3 | Uncharacterized protein. (210 aa) |
| | COL6A5 | Collagen type VI alpha 5 chain. (2603 aa) |
| | COL6A6 | Collagen type VI alpha 6 chain. (2268 aa) |
| | COL4A1 | Collagen type IV alpha 1 chain. (1586 aa) |
| | COL4A2 | Collagen type IV alpha 2 chain. (329 aa) |
| | DIAPH1 | Diaphanous related formin 1. (1283 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa) |
| | HGF | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1053 aa) |
| | FLT1 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | FLNB | Filamin B. (2633 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa) |
| | MYL9 | Myosin light chain 9. (172 aa) |
| | PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (328 aa) |
| | THBS1 | Thrombospondin 1. (1456 aa) |
| | PAK6 | Non-specific serine/threonine protein kinase. (681 aa) |
| | COL2A1 | Collagen type II alpha 1 chain. (1488 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | IBSP | Integrin binding sialoprotein. (319 aa) |
| | COL4A4 | Collagen type IV alpha 4 chain. (1688 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa) |
| | COL4A5 | Collagen alpha-5(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1691 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] (330 aa) |
| | LAMB2 | Laminin subunit beta 2. (1801 aa) |
| | LAMB3 | Laminin subunit beta 3. (1172 aa) |
| | VEGFD | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa) |
| | COL6A3 | Collagen type VI alpha 3 chain. (3169 aa) |
| | PIP5K1A | PIPK domain-containing protein. (562 aa) |
| | DOCK1 | Dedicator of cytokinesis 1; Belongs to the DOCK family. (1896 aa) |
| | LAMC2 | Laminin subunit gamma 2. (1196 aa) |
| | LOC610614 | Uncharacterized protein. (2364 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa) |
| | TNN | Tenascin N. (1441 aa) |
| | SHC4 | SHC adaptor protein 4. (632 aa) |
| | PIK3R2 | Uncharacterized protein. (726 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (617 aa) |
| | ELK1 | ETS transcription factor ELK1. (515 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | VCL | Vinculin. (1147 aa) |
| | CCND2 | Cyclin D2; Belongs to the cyclin family. (328 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | ERBB2 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1263 aa) |
| | CAPN2 | Calpain 2; Belongs to the peptidase C2 family. (666 aa) |
| | MYL5 | Myosin light chain 5. (289 aa) |
| | TLN2 | Talin 2. (2542 aa) |
| | ITGA3 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa) |
| | PGF | Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (213 aa) |
| | COL1A1 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1460 aa) |
| | THBS3 | Thrombospondin 3. (956 aa) |
| | CHAD | Chondroadherin. (359 aa) |
| | SHC1 | SHC adaptor protein 1. (577 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | ITGA2 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa) |
| | LAMA1 | Laminin subunit alpha 1. (3034 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | VTN | SMB domain-containing protein. (524 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (385 aa) |
| | PIP5K1C | Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa) |
| | FLNA | Filamin A. (2646 aa) |
| | SHC2 | Uncharacterized protein. (636 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa) |
| | COL1A2 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1366 aa) |
| | RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] (499 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | LAMA2 | Laminin subunit alpha 2. (3112 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (919 aa) |
| | ILK | Integrin linked kinase. (452 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | XIAP | Baculoviral IAP-repeat containing protein 4. (493 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | RELN | Reelin. (3459 aa) |
| | TNR | Tenascin R. (1358 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa) |
| | ARHGAP35 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] (1516 aa) |
| | COL4A6 | Collagen type IV alpha 6 chain. (1707 aa) |
| | MYLK2 | Myosin light chain kinase 2. (634 aa) |
| | ITGB4 | Integrin beta. (1766 aa) |
| | ITGA9 | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1063 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa) |
| | MYL7 | Uncharacterized protein. (203 aa) |
| | MYLK4 | Protein kinase domain-containing protein. (692 aa) |
| | PARVA | Parvin alpha. (398 aa) |
| | LAMC3 | Laminin subunit gamma 3. (1484 aa) |
| | HRAS | Uncharacterized protein. (189 aa) |
| | RAP1A | RAP1A, member of RAS oncogene family. (184 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1421 aa) |
| | COL4A3 | Collagen type IV alpha 3 chain. (1692 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (495 aa) |
| | COL6A1 | Collagen type VI alpha 1 chain. (1089 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1403 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (552 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa) |
| | ARHGAP5 | Rho GTPase activating protein 5. (1503 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ACTN1 | Actinin alpha 1. (956 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | LAMB1 | Laminin subunit beta 1. (1785 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (250 aa) |
| | PXN-2 | Uncharacterized protein. (258 aa) |
| | BIRC3 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] (635 aa) |
| | PARVB | Parvin beta. (360 aa) |
| | LAMA3 | Laminin subunit alpha 3. (3355 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1381 aa) |
| | THBS2 | Thrombospondin 2. (1170 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (337 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1033 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa) |
| | VWF | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (3256 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (551 aa) |
| | THBS4 | Thrombospondin 4. (1038 aa) |
| | ITGA2B | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1194 aa) |
| | ITGB7 | Integrin beta; Belongs to the integrin beta chain family. (734 aa) |
| | ITGA6 | Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa) |
| | LAMC1 | Laminin subunit gamma 1. (1528 aa) |
| | RAPGEF1 | Rap guanine nucleotide exchange factor 1. (1297 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (423 aa) |
| | RASGRF1 | Ras protein specific guanine nucleotide releasing factor 1. (1306 aa) |
| | PELO | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1208 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (341 aa) |
| | MYL10 | Myosin light chain 10. (187 aa) |
| | PPP1R12A | Protein phosphatase 1 regulatory subunit. (1084 aa) |
| | MYLPF | Myosin light chain, phosphorylatable, fast skeletal muscle. (181 aa) |
| | LAMA4 | Laminin subunit alpha 4. (1857 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (892 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa) |
| | ITGB8 | Integrin beta; Belongs to the integrin beta chain family. (811 aa) |
| | MYLK | Myosin light chain kinase. (2017 aa) |
| | MYL12B | Uncharacterized protein. (259 aa) |
| | CDC42-2 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa) |
| | LAMB4 | Laminin subunit beta 4. (1760 aa) |
| | ITGA11 | Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1209 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (380 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | ITGA7 | Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1186 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (859 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (718 aa) |
| | VASP | Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...] (419 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1283 aa) |
| | ITGA10 | Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1178 aa) |
| | MYL2 | Myosin light chain 2. (175 aa) |
| | ROCK2 | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa) |
| | FN1 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2586 aa) |
