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| | EP300 | E1A binding protein p300. (2308 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1141 aa) |
| | PARD3 | Par-3 family cell polarity regulator. (1258 aa) |
| | WASF1 | WASP family member 1. (559 aa) |
| | NECTIN2 | Nectin cell adhesion molecule 2. (541 aa) |
| | CTNNB1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (744 aa) |
| | ACTN4 | Actinin alpha 4. (1163 aa) |
| | RAC3 | Uncharacterized protein. (210 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (853 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | WASF3 | WASP family member 3. (502 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | FER | Tyrosine-protein kinase Fer; Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell attachment and cell migration. Acts downstream of EGFR, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)- mediated signaling in mast cells. Plays a role in the regulation of mast cell [...] (823 aa) |
| | CTNND1 | Catenin delta 1. (967 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (588 aa) |
| | NECTIN3 | Nectin cell adhesion molecule 3. (495 aa) |
| | SNAI1 | Snail family transcriptional repressor 1. (263 aa) |
| | NECTIN1 | Uncharacterized protein. (516 aa) |
| | WASF2 | WASP family member 2. (498 aa) |
| | NECTIN4 | Nectin cell adhesion molecule 4. (506 aa) |
| | IQGAP1 | IQ motif containing GTPase activating protein 1. (1657 aa) |
| | CTNNA3 | Catenin alpha 3. (895 aa) |
| | VCL | Vinculin. (1147 aa) |
| | ERBB2 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1263 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (611 aa) |
| | NLK | Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...] (527 aa) |
| | LOC489647 | Uncharacterized protein. (513 aa) |
| | CDH1 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. (885 aa) |
| | SSX2IP | SSX family member 2 interacting protein. (613 aa) |
| | RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type. (354 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | PTPRJ | Protein tyrosine phosphatase receptor type J. (1229 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1406 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (565 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1421 aa) |
| | TCF7 | Transcription factor 7. (484 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1403 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | FARP2 | FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1052 aa) |
| | PTPRB | Protein tyrosine phosphatase receptor type B. (2259 aa) |
| | LMO7 | LIM domain 7. (1921 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2. (571 aa) |
| | ACTN1 | Actinin alpha 1. (956 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | CTNNA1 | Catenin alpha 1. (918 aa) |
| | CTNNA2 | Catenin alpha 2. (953 aa) |
| | AFDN | Afadin, adherens junction formation factor. (1864 aa) |
| | CDC42-2 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa) |
| | PTPRF | Protein tyrosine phosphatase receptor type F. (1927 aa) |
| | PTPRM | Protein tyrosine phosphatase receptor type M. (1524 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa) |
| | YES1 | Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components su [...] (546 aa) |
| | TJP1 | Tight junction protein ZO-1; TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation [...] (1865 aa) |
| | WASL | WASP like actin nucleation promoting factor. (524 aa) |
