STRINGSTRING
INHBC INHBC POU5F1 POU5F1 FZD6 FZD6 MAPK12 MAPK12 NEUROG1 NEUROG1 MYC MYC SMAD5 SMAD5 MAPK13 MAPK13 FZD1 FZD1 DLX5 DLX5 REST REST HOXA1 HOXA1 WNT16 WNT16 INHBA INHBA PIK3R3 PIK3R3 INHBB-2 INHBB-2 RAF1 RAF1 ACVR2B ACVR2B CTNNB1 CTNNB1 WNT11 WNT11 AKT2 AKT2 KAT6A KAT6A RIF1 RIF1 MYF5 MYF5 FGFR1 FGFR1 SMAD9 SMAD9 FZD10 FZD10 ID1 ID1 PCGF5 PCGF5 PIK3CB PIK3CB PIK3R1 PIK3R1 SMAD1 SMAD1 HESX1 HESX1 FZD3 FZD3 PCGF1 PCGF1 WNT10B WNT10B LHX5 LHX5 NRAS NRAS WNT8B WNT8B ID4 ID4 DVL3 DVL3 FZD9 FZD9 ID3 ID3 FZD5 FZD5 NANOG NANOG BMP4 BMP4 WNT10A WNT10A PIK3R2 PIK3R2 AKT3 AKT3 ONECUT1 ONECUT1 WNT5B WNT5B BMPR1A BMPR1A DVL2 DVL2 LOC490387 LOC490387 FGFR4 FGFR4 PCGF2 PCGF2 HOXB1 HOXB1 SMAD3 SMAD3 HAND1 HAND1 AKT1 AKT1 ISL1 ISL1 ZIC3 ZIC3 DVL1 DVL1 APC2 APC2 PIK3CD PIK3CD ZFHX3 ZFHX3 WNT2B WNT2B ESX1 ESX1 MAPK1 MAPK1 FZD7 FZD7 BMPR2 BMPR2 GSK3B GSK3B LIF LIF JARID2 JARID2 NODAL NODAL HOXD1 HOXD1 WNT6 WNT6 PCGF6 PCGF6 WNT9B WNT9B OTX1 OTX1 WNT7A WNT7A JAK1 JAK1 LOC102154408 LOC102154408 HRAS HRAS WNT5A WNT5A JAK3 JAK3 WNT2 WNT2 SETDB1 SETDB1 SMARCAD1 SMARCAD1 WNT9A WNT9A TBX3 TBX3 MAP2K2 MAP2K2 TCF7 TCF7 IGF1R IGF1R JAK2 JAK2 BMPR1B BMPR1B MAP2K1 MAP2K1 WNT7B WNT7B ACVR1 ACVR1 LIFR LIFR FGFR3 FGFR3 MAPK14 MAPK14 PIK3CA PIK3CA APC APC GRB2 GRB2 MEIS1 MEIS1 BMI1 BMI1 ESRRB ESRRB STAT3 STAT3 PCGF3 PCGF3 SMAD4 SMAD4 WNT1 WNT1 FZD4 FZD4 AXIN1 AXIN1 SKIL SKIL ACVR2A ACVR2A WNT8A WNT8A IGF1 IGF1 LOC100682666 LOC100682666 MAPK11 MAPK11 IL6ST IL6ST SMAD2 SMAD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INHBCInhibin subunit beta C. (351 aa)
POU5F1POU domain protein. (360 aa)
FZD6Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (712 aa)
MAPK12Mitogen-activated protein kinase. (366 aa)
NEUROG1Neurogenin 1. (246 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (651 aa)
DLX5Distal-less homeobox 5. (289 aa)
RESTRE1 silencing transcription factor. (996 aa)
HOXA1Homeobox A1. (333 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (280 aa)
INHBAInhibin subunit beta A. (424 aa)
PIK3R3Uncharacterized protein. (461 aa)
INHBB-2Inhibin subunit beta B. (131 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
CTNNB1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (744 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2005 aa)
RIF1Replication timing regulatory factor 1. (2549 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (506 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
PCGF5Polycomb group ring finger 5. (296 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
HESX1HESX homeobox 1. (186 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LHX5LIM homeobox 5. (402 aa)
NRASUncharacterized protein. (189 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (224 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (594 aa)
ID3DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the [...] (119 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa)
NANOGHomeobox domain-containing protein. (304 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
PIK3R2Uncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ONECUT1One cut domain family member. (465 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
LOC490387Left-right determination factor. (367 aa)
FGFR4Fibroblast growth factor receptor. (860 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
HOXB1Homeobox B1. (305 aa)
SMAD3Mothers against decapentaplegic homolog. (611 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ISL1ISL LIM homeobox 1. (370 aa)
ZIC3Zic family member 3. (466 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
APC2APC regulator of WNT signaling pathway 2. (2072 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
ZFHX3Zinc finger homeobox 3. (3719 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
ESX1ESX homeobox 1. (264 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (910 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1313 aa)
NODALNodal growth differentiation factor. (378 aa)
HOXD1Homeobox D1. (252 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (339 aa)
PCGF6Polycomb group ring finger 6. (383 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
OTX1Orthodenticle homeobox 1. (355 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
LOC102154408Homeobox domain-containing protein. (387 aa)
HRASUncharacterized protein. (189 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1294 aa)
SMARCAD1Uncharacterized protein. (998 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
TBX3T-box transcription factor 3. (720 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
TCF7Transcription factor 7. (484 aa)
IGF1RTyrosine-protein kinase receptor. (1403 aa)
JAK2Janus kinase 2. (1407 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (471 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LIFRLeukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity). (1157 aa)
FGFR3Fibroblast growth factor receptor 3. (978 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
APCAPC regulator of WNT signaling pathway. (2851 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
MEIS1Meis homeobox 1. (503 aa)
BMI1RING-type domain-containing protein. (436 aa)
ESRRBEstrogen related receptor beta. (513 aa)
STAT3Signal transducer and activator of transcription. (793 aa)
PCGF3Polycomb group ring finger 3. (314 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (619 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa)
AXIN1Axin 1. (992 aa)
SKILSKI like proto-oncogene. (685 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (735 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
LOC100682666Uncharacterized protein. (315 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
IL6STUncharacterized protein. (954 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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