STRINGSTRING
SERPINB2 SERPINB2 C2 C2 CFB CFB PLG PLG C5 C5 C5AR1 C5AR1 CPB2 CPB2 PLAUR PLAUR THBD THBD F11 F11 FGB FGB FGG FGG F2R F2R F2RL2 F2RL2 CFH CFH CFI CFI CR2 CR2 C4BPA C4BPA KNG1 KNG1 MASP1 MASP1 SERPINE1 SERPINE1 C1R C1R LOC102156626 LOC102156626 SERPINC1 SERPINC1 C1QC C1QC TFPI TFPI PLAU PLAU F5 F5 SERPIND1 SERPIND1 F2RL3 F2RL3 F12 F12 MASP2 MASP2 SERPINA5 SERPINA5 C6 C6 C7 C7 C3 C3 C9 C9 VTN VTN C8B C8B F9 F9 SERPINF2 SERPINF2 F8 F8 SERPINA1 SERPINA1 LOC609365 LOC609365 CLU CLU C3AR1 C3AR1 FGA FGA MBL2 MBL2 C4BPB C4BPB BDKRB2 BDKRB2 C1QB C1QB C1QA C1QA CFHR5 CFHR5 CD59 CD59 LOC481722 LOC481722 C1S C1S C8A C8A VSIG4 VSIG4 PROCR PROCR VWF VWF F13B F13B F7 F7 F13A1 F13A1 CD55 CD55 PLAT PLAT F3 F3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SERPINB2Serpin family B member 2; Belongs to the serpin family. (416 aa)
C2Complement C2; Belongs to the peptidase S1 family. (780 aa)
CFBUncharacterized protein; Belongs to the peptidase S1 family. (823 aa)
PLGPlasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] (812 aa)
C5Complement C5. (1611 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity). (352 aa)
CPB2Carboxypeptidase B2. (423 aa)
PLAURPlasminogen activator, urokinase receptor. (374 aa)
THBDThrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated (By similarity). (578 aa)
F11Coagulation factor XI. (1419 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (491 aa)
FGGFibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhan [...] (437 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (401 aa)
F2RL2Coagulation factor II thrombin receptor like 2. (379 aa)
CFHUncharacterized protein. (1233 aa)
CFIComplement factor I; Belongs to the peptidase S1 family. (599 aa)
CR2Uncharacterized protein. (1337 aa)
C4BPAComplement component 4 binding protein alpha. (606 aa)
KNG1Kininogen 1. (650 aa)
MASP1Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (765 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (449 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (719 aa)
LOC102156626Uncharacterized protein. (312 aa)
SERPINC1Serpin family C member 1; Belongs to the serpin family. (544 aa)
C1QCComplement C1q C chain. (235 aa)
TFPITissue factor pathway inhibitor. (396 aa)
PLAUPlasminogen activator, urokinase. (543 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2222 aa)
SERPIND1Serpin family D member 1; Belongs to the serpin family. (546 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (390 aa)
F12Coagulation factor XII. (598 aa)
MASP2Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
SERPINA5Serpin family A member 5; Belongs to the serpin family. (509 aa)
C6Complement C6. (956 aa)
C7Complement C7. (892 aa)
C3Complement C3. (1566 aa)
C9Complement C9. (568 aa)
VTNSMB domain-containing protein. (524 aa)
C8BComplement C8 beta chain. (590 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family. (459 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
F8Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. (2343 aa)
SERPINA1Serpin family A member 1; Belongs to the serpin family. (421 aa)
LOC609365Uncharacterized protein. (395 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself (By similarity). Binding to cell surface receptors triggers internalization of the chaperone-client complex and [...] (467 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (484 aa)
FGAFibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] (981 aa)
MBL2C-type lectin domain-containing protein. (282 aa)
C4BPBComplement component 4 binding protein beta. (255 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
C1QBComplement C1q B chain. (250 aa)
C1QAComplement C1q A chain. (264 aa)
CFHR5Complement factor H related 5. (569 aa)
CD59CD59 molecule. (123 aa)
LOC481722Uncharacterized protein. (1738 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (696 aa)
C8AComplement C8 alpha chain. (608 aa)
VSIG4V-set and immunoglobulin domain containing 4. (403 aa)
PROCRMHC_I-like_Ag-recog domain-containing protein. (261 aa)
VWFVon Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (3256 aa)
F13BCoagulation factor XIII B chain. (729 aa)
F7Coagulation factor X. (704 aa)
F13A1Coagulation factor XIII A chain. (794 aa)
CD55CD55 molecule. (405 aa)
PLATUncharacterized protein. (617 aa)
F3Coagulation factor III, tissue factor. (302 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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