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| | IL23A | Interleukin 23 subunit alpha. (193 aa) |
| | STAT2 | Signal transducer and activator of transcription. (844 aa) |
| | IL20RA | Interleukin 20 receptor subunit alpha. (558 aa) |
| | IL22RA2 | Interleukin 22 receptor subunit alpha 2. (231 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (475 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | IL22 | Interleukin 22. (179 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] (1099 aa) |
| | IL3 | Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa) |
| | IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa) |
| | IL13 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
| | EP300 | E1A binding protein p300. (2308 aa) |
| | IL2RB | Fibronectin type-III domain-containing protein. (556 aa) |
| | CSF2RB | Colony stimulating factor 2 receptor beta common subunit. (902 aa) |
| | IFNB1 | Interferon-beta. (186 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (340 aa) |
| | IFNK | Interferon kappa. (209 aa) |
| | CNTFR | Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity). (372 aa) |
| | GALT | Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (775 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | CSF3R | Colony stimulating factor 3 receptor. (840 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1141 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | IL21 | Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity); Bel [...] (146 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | STAM | Signal transducing adaptor molecule. (538 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | IL2RA | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (268 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (557 aa) |
| | LOC612539 | Uncharacterized protein. (189 aa) |
| | STAM2 | Signal transducing adaptor molecule 2. (548 aa) |
| | IL5RA | Interleukin 5 receptor subunit alpha. (420 aa) |
| | SOCS2 | Suppressor of cytokine signaling 2. (299 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | IL20RB | Interleukin 20 receptor subunit beta. (311 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | IL7 | Interleukin 7. (155 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (374 aa) |
| | LOC609830 | Uncharacterized protein. (569 aa) |
| | PRL | Prolactin. (229 aa) |
| | CISH | Cytokine inducible SH2 containing protein. (257 aa) |
| | CRLF2 | Cytokine receptor like factor 2. (373 aa) |
| | CSF2RA | Colony stimulating factor 2 receptor alpha subunit. (576 aa) |
| | IL3RA | Interleukin 3 receptor subunit alpha. (489 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa) |
| | IL19 | Interleukin 19. (177 aa) |
| | IL20 | Interleukin 20. (176 aa) |
| | IL24 | Interleukin 24. (192 aa) |
| | IL29L | Interferon lambda. (190 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa) |
| | AOX4 | Uncharacterized protein. (1337 aa) |
| | AOX2 | Uncharacterized protein. (1347 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family. (350 aa) |
| | OSM | Oncostatin M. (247 aa) |
| | GH1 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (449 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa) |
| | EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (200 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa) |
| | PIK3R2 | Uncharacterized protein. (726 aa) |
| | IL12RB1 | Interleukin 12 receptor subunit beta 1. (732 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | CCND2 | Cyclin D2; Belongs to the cyclin family. (328 aa) |
| | STAT5B | Signal transducer and activator of transcription. (787 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa) |
| | CTF1 | Uncharacterized protein. (201 aa) |
| | IL6R | Interleukin 6 receptor. (468 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa) |
| | EPOR | Erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity). (508 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | IL12RB2 | Interleukin 12 receptor subunit beta 2. (858 aa) |
| | IL23R | Interleukin 23 receptor. (631 aa) |
| | LEPR | Leptin receptor. (1166 aa) |
| | OSMR | Oncostatin M receptor. (968 aa) |
| | IL7R | Interleukin 7 receptor. (456 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (408 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (197 aa) |
| | FHL1 | Four and a half LIM domains 1. (339 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (521 aa) |
| | LOC611642 | Fibronectin type-III domain-containing protein. (505 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa) |
| | IL13RA1 | Interleukin 13 receptor subunit alpha 1. (427 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa) |
| | MPL | MPL proto-oncogene, thrombopoietin receptor. (535 aa) |
| | LIF | LIF interleukin 6 family cytokine. (202 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | IL21R | Interleukin 21 receptor. (543 aa) |
| | LOC100686341 | Fibronectin type-III domain-containing protein. (402 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | HRAS | Uncharacterized protein. (189 aa) |
| | TSLP | Thymic stromal lymphopoietin. (117 aa) |
| | IL2RG | Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. (373 aa) |
| | JAK3 | Tyrosine-protein kinase. (1103 aa) |
| | IL17D | Uncharacterized protein. (181 aa) |
| | IL22RA1 | Interleukin 22 receptor subunit alpha 1. (578 aa) |
| | IFNLR1 | Interferon lambda receptor 1. (502 aa) |
| | SOCS6 | Suppressor of cytokine signaling 6. (535 aa) |
| | IL4R | Interleukin 4 receptor. (835 aa) |
| | JAK2 | Janus kinase 2. (1407 aa) |
| | IFNGR2 | Uncharacterized protein. (435 aa) |
| | LOC100683416 | Uncharacterized protein. (178 aa) |
| | IFNA5 | Interferon alpha-3; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | LOC100687692 | Uncharacterized protein. (187 aa) |
| | LOC100683202 | Interferon alpha-1/2; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | PRLR | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (625 aa) |
| | LIFR | Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity). (1157 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PIAS2 | Protein inhibitor of activated STAT 2. (612 aa) |
| | STAT1 | Signal transducer and activator of transcription. (774 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (250 aa) |
| | IFNAR1 | Uncharacterized protein. (572 aa) |
| | TYK2 | Tyrosine-protein kinase. (1173 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (357 aa) |
| | STAT3 | Signal transducer and activator of transcription. (793 aa) |
| | STAT4 | Signal transducer and activator of transcription. (772 aa) |
| | LOC100686162 | Uncharacterized protein. (175 aa) |
| | IFNA7 | Interferon-alpha. (187 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa) |
| | LOC100687857 | Uncharacterized protein. (187 aa) |
| | PIAS3 | Protein inhibitor of activated STAT 3. (849 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (423 aa) |
| | LOC489915 | Uncharacterized protein. (185 aa) |
| | IL9 | Interleukin 9. (139 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (341 aa) |
| | IL13RA2 | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13); Belongs to the type I cytokine receptor family. Type 5 subfamily. (406 aa) |
| | LOC487739 | Uncharacterized protein. (363 aa) |
| | GHR | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). (645 aa) |
| | IFNAR2 | Uncharacterized protein. (522 aa) |
| | GFAP | Glial fibrillary acidic protein; Belongs to the intermediate filament family. (489 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (380 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa) |
| | IL6ST | Uncharacterized protein. (954 aa) |
| | LOC100683567 | Uncharacterized protein. (196 aa) |
| | CSF3 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes; Belongs to the IL-6 superfamily. (204 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1283 aa) |
| | PIAS1 | Protein inhibitor of activated STAT 1. (655 aa) |
| | THPO | Thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. (352 aa) |
