STRINGSTRING
TNF TNF HLA-DQB2 HLA-DQB2 HLA-DQB1 HLA-DQB1 IL3 IL3 IL5 IL5 IL4 IL4 DLA-DOA DLA-DOA GALT GALT KIT KIT IL1R2 IL1R2 CSF3R CSF3R IL2RA IL2RA IL5RA IL5RA CD36 CD36 ITGA5 ITGA5 IL1B IL1B IL7 IL7 DNTT DNTT CD2 CD2 CSF2RA CSF2RA IL3RA IL3RA FCGR1A FCGR1A CR2 CR2 CD34 CD34 ANPEP ANPEP CD3G CD3G TFRC TFRC EPO EPO CD5 CD5 ITGA3 ITGA3 IL6R IL6R CD19 CD19 EPOR EPOR ITGA2 ITGA2 IL7R IL7R LOC611642 LOC611642 CSF2 CSF2 ITGB3 ITGB3 MS4A1 MS4A1 GP1BB GP1BB CD7 CD7 GYPA GYPA CD3D CD3D IL1A IL1A LOC100686341 LOC100686341 CD59 CD59 CD38 CD38 IL4R IL4R DLA-DRA DLA-DRA IL1R1 IL1R1 CD37 CD37 FLT3 FLT3 IL6 IL6 CSF1R CSF1R ITGA2B ITGA2B ITGA6 ITGA6 PELO PELO CD55 CD55 CSF1 CSF1 CD4 CD4 CSF3 CSF3 MME MME KITLG KITLG THPO THPO
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (205 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 2. (303 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
DLA-DOAMHC class II antigen DO alpha; Belongs to the MHC class II family. (250 aa)
GALTGalactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (775 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
IL1R2Interleukin 1 receptor type 2. (595 aa)
CSF3RColony stimulating factor 3 receptor. (840 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (268 aa)
IL5RAInterleukin 5 receptor subunit alpha. (420 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1053 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa)
IL7Interleukin 7. (155 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa)
CD2CD2 molecule. (339 aa)
CSF2RAColony stimulating factor 2 receptor alpha subunit. (576 aa)
IL3RAInterleukin 3 receptor subunit alpha. (489 aa)
FCGR1AUncharacterized protein. (428 aa)
CR2Uncharacterized protein. (1337 aa)
CD34Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). (390 aa)
ANPEPAminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] (975 aa)
CD3GCD3g molecule. (182 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...] (918 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (200 aa)
CD5CD5 molecule. (511 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
IL6RInterleukin 6 receptor. (468 aa)
CD19CD19 molecule. (611 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity). (508 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
IL7RInterleukin 7 receptor. (456 aa)
LOC611642Fibronectin type-III domain-containing protein. (505 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (919 aa)
MS4A1B-lymphocyte antigen CD20; B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. (333 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (247 aa)
CD7CD7 molecule. (210 aa)
GYPAGlycophorin-A; Glycophorin A is the major intrinsic membrane sialoglycoprotein of the erythrocyte. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane (By similarity). (129 aa)
CD3DCD3d molecule. (194 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (273 aa)
LOC100686341Fibronectin type-III domain-containing protein. (402 aa)
CD59CD59 molecule. (123 aa)
CD38CD38 molecule. (361 aa)
IL4RInterleukin 4 receptor. (835 aa)
DLA-DRAIg-like domain-containing protein; Belongs to the MHC class II family. (342 aa)
IL1R1Interleukin 1 receptor type 1. (629 aa)
CD37Tetraspanin. (467 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1029 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1194 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
PELOIntegrin subunit alpha 1; Belongs to the integrin alpha chain family. (1208 aa)
CD55CD55 molecule. (405 aa)
CSF1Colony stimulating factor 1. (587 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa)
CSF3Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes; Belongs to the IL-6 superfamily. (204 aa)
MMEUncharacterized protein. (770 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins. (335 aa)
THPOThrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. (352 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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