STRINGSTRING
IFNGR1 IFNGR1 MAML1 MAML1 IFNG IFNG MAPK12 MAPK12 HLA-DQB2 HLA-DQB2 HLA-DQB1 HLA-DQB1 IL5 IL5 IL13 IL13 IL4 IL4 DLA-DOA DLA-DOA MAPK13 MAPK13 IL2RB IL2RB NFKBIE NFKBIE MAML3 MAML3 IL2 IL2 DLL1 DLL1 GATA3 GATA3 PRKCQ PRKCQ IL2RA IL2RA JAG1 JAG1 MAPK10 MAPK10 DLL4 DLL4 CHUK CHUK NOTCH2 NOTCH2 PPP3CA PPP3CA LCK LCK NFATC2 NFATC2 CD3G CD3G RELA RELA NFKBIA NFKBIA IL12A IL12A IL12RB1 IL12RB1 STAT5A STAT5A STAT5B STAT5B NOTCH3 NOTCH3 TBX21 TBX21 FOS FOS IL12B IL12B LAT LAT IL12RB2 IL12RB2 IKBKG IKBKG NOTCH1 NOTCH1 MAPK1 MAPK1 NFATC1 NFATC1 CD3D CD3D JAK1 JAK1 PPP3CC PPP3CC IL2RG IL2RG JAK3 JAK3 CD247 CD247 IL4R IL4R JAK2 JAK2 PPP3CB PPP3CB IFNGR2 IFNGR2 DLA-DRA DLA-DRA PLCG1 PLCG1 MAPK8 MAPK8 IKBKB IKBKB MAPK14 MAPK14 STAT1 STAT1 TYK2 TYK2 STAT4 STAT4 NFATC3 NFATC3 NFKB1 NFKB1 LOC487739 LOC487739 MAPK11 MAPK11 MAPK9 MAPK9 CD4 CD4 RBPJ RBPJ PPP3R1 PPP3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNGR1Interferon gamma receptor 1. (475 aa)
MAML1Mastermind like transcriptional coactivator 1. (1011 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
MAPK12Mitogen-activated protein kinase. (366 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (205 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 2. (303 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
DLA-DOAMHC class II antigen DO alpha; Belongs to the MHC class II family. (250 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
IL2RBFibronectin type-III domain-containing protein. (556 aa)
NFKBIEANK_REP_REGION domain-containing protein. (267 aa)
MAML3Mastermind like transcriptional coactivator 3. (1098 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
GATA3GATA binding protein 3. (444 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (268 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (732 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
NOTCH2Notch receptor 2. (2726 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LCKTyrosine-protein kinase. (509 aa)
NFATC2Nuclear factor of activated T cells 2. (1086 aa)
CD3GCD3g molecule. (182 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (732 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
NOTCH3Notch receptor 3. (2148 aa)
TBX21T-box transcription factor 21. (535 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
LATLinker for activation of T cells. (290 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (858 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
NOTCH1Notch receptor 1. (2565 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
NFATC1Nuclear factor of activated T cells 1. (923 aa)
CD3DCD3d molecule. (194 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
PPP3CCSerine/threonine-protein phosphatase. (540 aa)
IL2RGCytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. (373 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
CD247Uncharacterized protein. (199 aa)
IL4RInterleukin 4 receptor. (835 aa)
JAK2Janus kinase 2. (1407 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
IFNGR2Uncharacterized protein. (435 aa)
DLA-DRAIg-like domain-containing protein; Belongs to the MHC class II family. (342 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
STAT1Signal transducer and activator of transcription. (774 aa)
TYK2Tyrosine-protein kinase. (1173 aa)
STAT4Signal transducer and activator of transcription. (772 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
LOC487739Uncharacterized protein. (363 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (513 aa)
PPP3R1Uncharacterized protein. (169 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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