STRINGSTRING
IL23A IL23A IFNGR1 IFNGR1 IFNG IFNG IL22 IL22 MAPK12 MAPK12 HLA-DQB2 HLA-DQB2 HLA-DQB1 HLA-DQB1 IL4 IL4 DLA-DOA DLA-DOA RXRB RXRB MAPK13 MAPK13 IL2RB IL2RB HSP90AB1 HSP90AB1 NFKBIE NFKBIE IL21 IL21 IL2 IL2 B9D2 B9D2 GATA3 GATA3 PRKCQ PRKCQ IL2RA IL2RA RARA RARA LOC609817 LOC609817 IL1B IL1B IRF4 IRF4 MAPK10 MAPK10 CHUK CHUK RUNX1 RUNX1 PPP3CA PPP3CA LCK LCK NFATC2 NFATC2 CD3G CD3G RORC RORC RELA RELA NFKBIA NFKBIA IL1RAP IL1RAP IL12RB1 IL12RB1 STAT5A STAT5A STAT5B STAT5B FOXP3 FOXP3 MTOR MTOR RORA RORA TBX21 TBX21 FOS FOS IL6R IL6R LAT LAT SMAD3 SMAD3 HSP90AA1 HSP90AA1 IL23R IL23R IKBKG IKBKG MAPK1 MAPK1 NFATC1 NFATC1 IL21R IL21R CD3D CD3D JAK1 JAK1 TGFBR1 TGFBR1 PPP3CC PPP3CC IL2RG IL2RG JAK3 JAK3 IL17D IL17D CD247 CD247 IL4R IL4R JAK2 JAK2 PPP3CB PPP3CB IL17A IL17A IFNGR2 IFNGR2 DLA-DRA DLA-DRA IL1R1 IL1R1 PLCG1 PLCG1 MAPK8 MAPK8 IKBKB IKBKB MAPK14 MAPK14 STAT1 STAT1 TYK2 TYK2 STAT3 STAT3 RXRG RXRG AHR AHR SMAD4 SMAD4 NFATC3 NFATC3 IL6 IL6 NFKB1 NFKB1 LOC487739 LOC487739 RXRA RXRA IL17F IL17F MAPK11 MAPK11 IL6ST IL6ST TGFBR2 TGFBR2 MAPK9 MAPK9 CD4 CD4 HIF1A HIF1A SMAD2 SMAD2 PPP3R1 PPP3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL23AInterleukin 23 subunit alpha. (193 aa)
IFNGR1Interferon gamma receptor 1. (475 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
IL22Interleukin 22. (179 aa)
MAPK12Mitogen-activated protein kinase. (366 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (205 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 2. (303 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
DLA-DOAMHC class II antigen DO alpha; Belongs to the MHC class II family. (250 aa)
RXRBRetinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE); Belongs to the nuclear hormone receptor family. NR2 subfamily. (536 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
IL2RBFibronectin type-III domain-containing protein. (556 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
NFKBIEANK_REP_REGION domain-containing protein. (267 aa)
IL21Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity); Bel [...] (146 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
GATA3GATA binding protein 3. (444 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (268 aa)
RARARetinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcri [...] (462 aa)
LOC609817IRF tryptophan pentad repeat domain-containing protein. (441 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa)
IRF4Interferon regulatory factor 4. (428 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LCKTyrosine-protein kinase. (509 aa)
NFATC2Nuclear factor of activated T cells 2. (1086 aa)
CD3GCD3g molecule. (182 aa)
RORCRAR related orphan receptor C. (518 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
IL1RAPInterleukin 1 receptor accessory protein. (685 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (732 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
FOXP3Forkhead box P3. (452 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
RORARAR related orphan receptor A. (528 aa)
TBX21T-box transcription factor 21. (535 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL6RInterleukin 6 receptor. (468 aa)
LATLinker for activation of T cells. (290 aa)
SMAD3Mothers against decapentaplegic homolog. (611 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (542 aa)
IL23RInterleukin 23 receptor. (631 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
NFATC1Nuclear factor of activated T cells 1. (923 aa)
IL21RInterleukin 21 receptor. (543 aa)
CD3DCD3d molecule. (194 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
PPP3CCSerine/threonine-protein phosphatase. (540 aa)
IL2RGCytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. (373 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
IL17DUncharacterized protein. (181 aa)
CD247Uncharacterized protein. (199 aa)
IL4RInterleukin 4 receptor. (835 aa)
JAK2Janus kinase 2. (1407 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
IL17AInterleukin 17A. (156 aa)
IFNGR2Uncharacterized protein. (435 aa)
DLA-DRAIg-like domain-containing protein; Belongs to the MHC class II family. (342 aa)
IL1R1Interleukin 1 receptor type 1. (629 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
STAT1Signal transducer and activator of transcription. (774 aa)
TYK2Tyrosine-protein kinase. (1173 aa)
STAT3Signal transducer and activator of transcription. (793 aa)
RXRGRetinoid X receptor gamma. (538 aa)
AHRAryl hydrocarbon receptor. (853 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
LOC487739Uncharacterized protein. (363 aa)
RXRARetinoid X receptor alpha. (556 aa)
IL17FInterleukin 17F. (196 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
IL6STUncharacterized protein. (954 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa)
HIF1AUncharacterized protein. (823 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PPP3R1Uncharacterized protein. (169 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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