STRINGSTRING
MALT1 MALT1 RAC2 RAC2 NFKBIE NFKBIE PIK3R3 PIK3R3 RAF1 RAF1 AKT2 AKT2 INPPL1 INPPL1 RAC3 RAC3 SOS1 SOS1 PIK3CB PIK3CB PIK3R1 PIK3R1 NRAS NRAS CHUK CHUK CD81 CD81 DAPP1 DAPP1 PPP3CA PPP3CA NFATC2 NFATC2 CR2 CR2 CD79B CD79B RELA RELA NFKBIA NFKBIA SOS2 SOS2 PIK3R2 PIK3R2 AKT3 AKT3 CARD11 CARD11 FOS FOS CD19 CD19 PRKCB PRKCB AKT1 AKT1 VAV1 VAV1 IKBKG IKBKG PIK3CD PIK3CD PLCG2 PLCG2 BCL10 BCL10 MAPK1 MAPK1 NFATC1 NFATC1 GSK3B GSK3B HRAS HRAS PIK3AP1 PIK3AP1 PPP3CC PPP3CC MAP2K2 MAP2K2 BTK BTK PPP3CB PPP3CB MAP2K1 MAP2K1 LYN LYN IKBKB IKBKB PIK3CA PIK3CA GRB2 GRB2 BLNK BLNK NFATC3 NFATC3 CD79A CD79A RASGRP3 RASGRP3 LOC611446 LOC611446 SYK SYK NFKB1 NFKB1 INPP5D INPP5D VAV3 VAV3 PPP3R1 PPP3R1 LOC484309 LOC484309
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MALT1MALT1 paracaspase. (758 aa)
RAC2Rac family small GTPase 2. (192 aa)
NFKBIEANK_REP_REGION domain-containing protein. (267 aa)
PIK3R3Uncharacterized protein. (461 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
RAC3Uncharacterized protein. (210 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
NRASUncharacterized protein. (189 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CD81Tetraspanin. (233 aa)
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
NFATC2Nuclear factor of activated T cells 2. (1086 aa)
CR2Uncharacterized protein. (1337 aa)
CD79BCD79b molecule. (222 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa)
PIK3R2Uncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CD19CD19 molecule. (611 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
NFATC1Nuclear factor of activated T cells 1. (923 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
HRASUncharacterized protein. (189 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (821 aa)
PPP3CCSerine/threonine-protein phosphatase. (540 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
BTKTyrosine-protein kinase. (687 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
LYNTyrosine-protein kinase. (566 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
BLNKB cell linker. (483 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
CD79AB-cell antigen receptor complex-associated protein alpha chain; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts wit [...] (284 aa)
RASGRP3RAS guanyl releasing protein 3. (697 aa)
LOC611446Uncharacterized protein. (651 aa)
SYKTyrosine-protein kinase. (699 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1501 aa)
VAV3Vav guanine nucleotide exchange factor 3. (859 aa)
PPP3R1Uncharacterized protein. (169 aa)
LOC484309Uncharacterized protein. (552 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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