STRINGSTRING
TNF TNF MAPK12 MAPK12 IL3 IL3 IL5 IL5 IL13 IL13 IL4 IL4 MAPK13 MAPK13 RAC2 RAC2 PIK3R3 PIK3R3 GAB2 GAB2 RAF1 RAF1 AKT2 AKT2 RAC3 RAC3 SOS1 SOS1 ALOX5 ALOX5 PIK3CB PIK3CB PIK3R1 PIK3R1 MAPK10 MAPK10 NRAS NRAS PLA2G4D PLA2G4D PLA2G4F PLA2G4F MS4A2 MS4A2 PRKCA PRKCA FCER1A FCER1A FCER1G FCER1G PLA2G4A PLA2G4A SOS2 SOS2 PIK3R2 PIK3R2 AKT3 AKT3 LAT LAT AKT1 AKT1 VAV1 VAV1 PIK3CD PIK3CD PLCG2 PLCG2 MAPK1 MAPK1 CSF2 CSF2 LOC102155967 LOC102155967 LCP2 LCP2 HRAS HRAS JMJD7 JMJD7 MAP2K2 MAP2K2 BTK BTK LOC102155828 LOC102155828 MAP2K1 MAP2K1 LYN LYN PLCG1 PLCG1 MAPK8 MAPK8 MAPK14 MAPK14 PIK3CA PIK3CA MAP2K4 MAP2K4 GRB2 GRB2 PDPK1 PDPK1 SYK SYK PLA2G4E PLA2G4E INPP5D INPP5D MAP2K6 MAP2K6 MAP2K3 MAP2K3 LOC111091602 LOC111091602 MAPK11 MAPK11 MAPK9 MAPK9 ALOX5AP ALOX5AP VAV3 VAV3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MAPK12Mitogen-activated protein kinase. (366 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
RAC2Rac family small GTPase 2. (192 aa)
PIK3R3Uncharacterized protein. (461 aa)
GAB2GRB2 associated binding protein 2. (663 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
RAC3Uncharacterized protein. (210 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
ALOX5Arachidonate 5-lipoxygenase. (642 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NRASUncharacterized protein. (189 aa)
PLA2G4DPhospholipase A2. (812 aa)
PLA2G4FPhospholipase A2. (870 aa)
MS4A2Membrane spanning 4-domains A2. (243 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
FCER1AFc fragment of IgE receptor Ia. (357 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
PLA2G4APhospholipase A2. (749 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa)
PIK3R2Uncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LATLinker for activation of T cells. (290 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
LOC102155967Uncharacterized protein. (237 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
HRASUncharacterized protein. (189 aa)
JMJD7Phospholipase A2. (841 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
BTKTyrosine-protein kinase. (687 aa)
LOC102155828Uncharacterized protein. (243 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
LYNTyrosine-protein kinase. (566 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (413 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (551 aa)
SYKTyrosine-protein kinase. (699 aa)
PLA2G4EPhospholipase A2. (891 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1501 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (517 aa)
LOC111091602Uncharacterized protein. (265 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (255 aa)
VAV3Vav guanine nucleotide exchange factor 3. (859 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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