STRINGSTRING
ASAP1 ASAP1 PLA2G6 PLA2G6 RAC2 RAC2 PIP5K1B PIP5K1B PRKCG PRKCG WASF1 WASF1 SPHK2 SPHK2 PIK3R3 PIK3R3 GAB2 GAB2 RAF1 RAF1 SPHK1 SPHK1 ARPC4 ARPC4 AKT2 AKT2 INPPL1 INPPL1 WASF3 WASF3 PIK3CB PIK3CB PIK3R1 PIK3R1 PRKCD PRKCD PLA2G4D PLA2G4D PLA2G4F PLA2G4F PRKCA PRKCA F1Q1C8_CANLF F1Q1C8_CANLF FCGR1A FCGR1A WASF2 WASF2 LIMK1 LIMK1 PIP5K1A PIP5K1A DOCK1 DOCK1 ARPC5 ARPC5 PLA2G4A PLA2G4A ARPC2 ARPC2 PIK3R2 PIK3R2 CRKL CRKL AKT3 AKT3 LAT LAT PRKCB PRKCB DNM2 DNM2 RPS6KB1 RPS6KB1 AKT1 AKT1 VAV1 VAV1 CRK CRK PIP5K1C PIP5K1C PLPP2 PLPP2 PIK3CD PIK3CD PLCG2 PLCG2 MAPK1 MAPK1 MARCKSL1 MARCKSL1 ARPC1A ARPC1A ARPC5L ARPC5L RPS6KB2 RPS6KB2 JMJD7 JMJD7 ASAP3 ASAP3 SCIN SCIN PAK1 PAK1 MAP2K1 MAP2K1 LYN LYN PLCG1 PLCG1 PRKCE PRKCE PIK3CA PIK3CA ARF6 ARF6 PTPRC PTPRC SYK SYK PLA2G4E PLA2G4E INPP5D INPP5D LOC478984 LOC478984 CDC42-2 CDC42-2 ARPC1B ARPC1B PLPP1 PLPP1 MYO10 MYO10 VAV3 VAV3 VASP VASP MARCKS MARCKS CFL1 CFL1 ARPC3-2 ARPC3-2 CFL2 CFL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1132 aa)
PLA2G6Phospholipase A2 group VI. (836 aa)
RAC2Rac family small GTPase 2. (192 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (543 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
WASF1WASP family member 1. (559 aa)
SPHK2Sphingosine kinase 2. (733 aa)
PIK3R3Uncharacterized protein. (461 aa)
GAB2GRB2 associated binding protein 2. (663 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SPHK1Sphingosine kinase 1. (487 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (186 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
WASF3WASP family member 3. (502 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCDProtein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of [...] (674 aa)
PLA2G4DPhospholipase A2. (812 aa)
PLA2G4FPhospholipase A2. (870 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
F1Q1C8_CANLFADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (207 aa)
FCGR1AUncharacterized protein. (428 aa)
WASF2WASP family member 2. (498 aa)
LIMK1LIM domain kinase 1. (761 aa)
PIP5K1APIPK domain-containing protein. (562 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1896 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
PLA2G4APhospholipase A2. (749 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (275 aa)
PIK3R2Uncharacterized protein. (726 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LATLinker for activation of T cells. (290 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
PLPP2Phospholipid phosphatase 2. (545 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MARCKSL1MARCKS like 1. (199 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (405 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (510 aa)
JMJD7Phospholipase A2. (841 aa)
ASAP3Uncharacterized protein. (388 aa)
SCINScinderin. (468 aa)
PAK1Non-specific serine/threonine protein kinase. (552 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
LYNTyrosine-protein kinase. (566 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
PRKCEProtein kinase C. (750 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1385 aa)
SYKTyrosine-protein kinase. (699 aa)
PLA2G4EPhospholipase A2. (891 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1501 aa)
LOC478984Uncharacterized protein. (286 aa)
CDC42-2Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (386 aa)
PLPP1Phospholipid phosphatase 1. (284 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2035 aa)
VAV3Vav guanine nucleotide exchange factor 3. (859 aa)
VASPVasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...] (419 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (356 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (200 aa)
ARPC3-2Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (143 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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