STRINGSTRING
ADCY8 ADCY8 GNGT1 GNGT1 GNG11 GNG11 CALM2 CALM2 PRKCG PRKCG ADCY3 ADCY3 MTNR1B MTNR1B GNG8 GNG8 F1PIP2_CANLF F1PIP2_CANLF F1PIN6_CANLF F1PIN6_CANLF GRIN2C GRIN2C CALML5 CALML5 PLCB4 PLCB4 RYR1 RYR1 ITPR1 ITPR1 RYR3 RYR3 GUCY1A1 GUCY1A1 PRKG2 PRKG2 PLCB2 PLCB2 KCNJ3 KCNJ3 RYR2 RYR2 KCNJ5 KCNJ5 ADCY2 ADCY2 CACNA1C CACNA1C GNB4 GNB4 PRKCA PRKCA CAMK2D CAMK2D ADCY4 ADCY4 PER2 PER2 CREB1 CREB1 GNG3 GNG3 GRIA4 GRIA4 ADCY10 ADCY10 GNB5 GNB5 GNAI1 GNAI1 GNGT2 GNGT2 FOS FOS CACNA1G CACNA1G CALML4 CALML4 RPS6KA5 RPS6KA5 PRKCB PRKCB GRIA1 GRIA1 RASD1 RASD1 GRIA3 GRIA3 GRIN2A GRIN2A CALML6 CALML6 GNB1 GNB1 GNAQ GNAQ GNG10 GNG10 GNG13 GNG13 PER3 PER3 GNAI3 GNAI3 PRKACB PRKACB MAPK1 MAPK1 GNAI2 GNAI2 GNB2 GNB2 PRKG1 PRKG1 PLCB3 PLCB3 CACNA1I CACNA1I GRIN1 GRIN1 GNG4 GNG4 KCNJ9 KCNJ9 GRIN2B GRIN2B ADCY6 ADCY6 NOS1 NOS1 GNG12 GNG12 ADCY9 ADCY9 J9P9F2_CANLF J9P9F2_CANLF GNG2 GNG2 GNG5 GNG5 ITPR3 ITPR3 KCNJ6 KCNJ6 PRKACA PRKACA GRIA2 GRIA2 GUCY1A2 GUCY1A2 CACNA1D CACNA1D CAMK2G CAMK2G PLCB1 PLCB1 GNB3 GNB3 CAMK2A CAMK2A GUCY1B1 GUCY1B1 CACNA1H CACNA1H GNG14 GNG14 GRIN2D GRIN2D PER1 PER1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
GNGT1Guanine nucleotide-binding protein G(T) subunit gamma-T1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (182 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (286 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
F1PIP2_CANLFGuanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1085 aa)
F1PIN6_CANLFUncharacterized protein; Belongs to the calmodulin family. (364 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1212 aa)
CALML5Calmodulin like 5. (169 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
RYR1Ryanodine receptor 1. (5038 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2628 aa)
RYR3Ryanodine receptor 3. (4842 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
RYR2Ryanodine receptor 2. (4903 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1051 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2171 aa)
GNB4G protein subunit beta 4. (340 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PER2Period circadian regulator 2. (1265 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
ADCY10Adenylate cyclase 10. (1610 aa)
GNB5G protein subunit beta 5. (391 aa)
GNAI1G protein subunit alpha i1. (337 aa)
GNGT2Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2380 aa)
CALML4Calmodulin like 4. (120 aa)
RPS6KA5Ribosomal protein S6 kinase. (793 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (938 aa)
RASD1Ras related dexamethasone induced 1. (279 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
CALML6Calmodulin like 6. (156 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (340 aa)
GNAQGuanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG13G protein subunit gamma 13. (67 aa)
PER3Period circadian regulator 3. (1131 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). (355 aa)
GNB2G protein subunit beta 2. (340 aa)
PRKG1cGMP-dependent protein kinase. (671 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2190 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. (914 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (117 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (339 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator fo [...] (1485 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of prot [...] (1291 aa)
NOS1Nitric oxide synthase 1. (1465 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
J9P9F2_CANLFCaMKII_AD domain-containing protein. (241 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (101 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2689 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (461 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (821 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (773 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (611 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (344 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. (672 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2407 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1172 aa)
PER1Period circadian regulator 1. (1359 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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