STRINGSTRING
PIP4K2C PIP4K2C PDGFRB PDGFRB EZR EZR RAC2 RAC2 PIP5K1B PIP5K1B FGD3 FGD3 PPP1R12C PPP1R12C CHRM2 CHRM2 EGFR EGFR MYLK3 MYLK3 ITGB1 ITGB1 WASF1 WASF1 FGF21 FGF21 PIP4K2A PIP4K2A PIK3R3 PIK3R3 ITGA8 ITGA8 RAF1 RAF1 PAK3 PAK3 BRK1 BRK1 ARPC4 ARPC4 PAK5 PAK5 ACTN4 ACTN4 RAC3 RAC3 FGFR1 FGFR1 DIAPH1 DIAPH1 SOS1 SOS1 NCKAP1L NCKAP1L ITGA5 ITGA5 FGF20 FGF20 SPATA13 SPATA13 MRAS MRAS PIK3CB PIK3CB PIK3R1 PIK3R1 PFN2 PFN2 RRAS2 RRAS2 MYL9 MYL9 PDGFC PDGFC PAK6 PAK6 CHRM4 CHRM4 F2R F2R NRAS NRAS CYFIP1 CYFIP1 FGF8 FGF8 CHRM3 CHRM3 FGF3 FGF3 FGF19 FGF19 GNA13 GNA13 SSH1 SSH1 F1Q1C8_CANLF F1Q1C8_CANLF EGF EGF PPP1CA PPP1CA SSH3 SSH3 ARHGEF12 ARHGEF12 WASF2 WASF2 SLC9A1 SLC9A1 LIMK1 LIMK1 PIP5K1A PIP5K1A IQGAP1 IQGAP1 DOCK1 DOCK1 ARPC5 ARPC5 KNG1 KNG1 LPAR2 LPAR2 SOS2 SOS2 RDX RDX NCKAP1 NCKAP1 ARPC2 ARPC2 FGF7 FGF7 PIK3R2 PIK3R2 ARAF ARAF CRKL CRKL VCL VCL FGF23 FGF23 CHRM1 CHRM1 FGFR4 FGFR4 LOC106558389 LOC106558389 ITGAL ITGAL INSRR INSRR MYL5 MYL5 ITGA3 ITGA3 LPAR4 LPAR4 CYFIP2 CYFIP2 ITGA2 ITGA2 VAV1 VAV1 GIT1 GIT1 CRK CRK PIP5K1C PIP5K1C ITGAE ITGAE APC2 APC2 FGF22 FGF22 PIK3CD PIK3CD RHOA RHOA PPP1CC PPP1CC ITGAD ITGAD MAPK1 MAPK1 ARPC1A ARPC1A ITGB3 ITGB3 CHRM5 CHRM5 FGF5 FGF5 LPAR1 LPAR1 ARPC5L ARPC5L FGF1 FGF1 DIAPH3 DIAPH3 ARHGAP35 ARHGAP35 FGF10 FGF10 CXCL12 CXCL12 MYLK2 MYLK2 GNA12 GNA12 ITGB4 ITGB4 SSH2 SSH2 ITGA9 ITGA9 BDKRB2 BDKRB2 MYL7 MYL7 FGF4 FGF4 MYLK4 MYLK4 PFN4 PFN4 HRAS HRAS GNG12 GNG12 ARHGEF1 ARHGEF1 FGF16 FGF16 MAP2K2 MAP2K2 SCIN SCIN FGF6 FGF6 PAK1 PAK1 RRAS RRAS SRC SRC FGF9 FGF9 MAP2K1 MAP2K1 ARHGEF4-2 ARHGEF4-2 MARF1 MARF1 FGFR3 FGFR3 FGD1 FGD1 ACTN1 ACTN1 PIK3CA PIK3CA APC APC FGF18 FGF18 PXN-2 PXN-2 ROCK1 ROCK1 PPP1CB PPP1CB ITGAV ITGAV INS INS PTK2 PTK2 ITGA2B ITGA2B ITGB7 ITGB7 ITGA6 ITGA6 PDGFA PDGFA PELO PELO PDGFB PDGFB MYL10 MYL10 FGF17 FGF17 PPP1R12A PPP1R12A MYH9 MYH9 PIKFYVE PIKFYVE MYLPF MYLPF DIAPH2 DIAPH2 ARHGEF6 ARHGEF6 BCAR1 BCAR1 MSN MSN ITGB8 ITGB8 MYLK MYLK MYL12B MYL12B CDC42-2 CDC42-2 GNG14 GNG14 IQGAP2 IQGAP2 MYH10 MYH10 ARPC1B ARPC1B ITGA11 ITGA11 ENAH ENAH TIAM1 TIAM1 ARHGEF7 ARHGEF7 MYH14 MYH14 ITGA7 ITGA7 VAV3 VAV3 PAK2 PAK2 PIP4K2B PIP4K2B PDGFRA PDGFRA ITGA10 ITGA10 MYL2 MYL2 ENSCAFP00000066193 ENSCAFP00000066193 CFL1 CFL1 ARPC3-2 ARPC3-2 IQGAP3 IQGAP3 ROCK2 ROCK2 CFL2 CFL2 WASL WASL FN1 FN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (352 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] (1099 aa)
EZRFERM domain-containing protein. (586 aa)
RAC2Rac family small GTPase 2. (192 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (543 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (735 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (758 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (483 aa)
EGFRReceptor protein-tyrosine kinase. (1141 aa)
MYLK3Myosin light chain kinase 3. (850 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (820 aa)
WASF1WASP family member 1. (559 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
PIK3R3Uncharacterized protein. (461 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (993 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PAK3P21 (RAC1) activated kinase 3. (583 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (186 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
ACTN4Actinin alpha 4. (1163 aa)
RAC3Uncharacterized protein. (210 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
DIAPH1Diaphanous related formin 1. (1283 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
NCKAP1LNCK associated protein 1 like. (1133 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1053 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SPATA13Uncharacterized protein. (1331 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PFN2Profilin; Belongs to the profilin family. (91 aa)
RRAS2RAS related 2. (193 aa)
MYL9Myosin light chain 9. (172 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (328 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (401 aa)
NRASUncharacterized protein. (189 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1213 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). (203 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (601 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
GNA13G protein subunit alpha 13. (282 aa)
SSH1Slingshot protein phosphatase 1. (1056 aa)
F1Q1C8_CANLFADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (207 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa)
PPP1CASerine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] (330 aa)
SSH3Slingshot protein phosphatase 3. (649 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1543 aa)
WASF2WASP family member 2. (498 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
LIMK1LIM domain kinase 1. (761 aa)
PIP5K1APIPK domain-containing protein. (562 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1896 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
KNG1Kininogen 1. (650 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa)
RDXRadixin. (604 aa)
NCKAP1NCK associated protein 1. (1102 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (275 aa)
FGF7Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity). (194 aa)
PIK3R2Uncharacterized protein. (726 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (605 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
VCLVinculin. (1147 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (312 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
FGFR4Fibroblast growth factor receptor. (860 aa)
LOC106558389Profilin; Belongs to the profilin family. (153 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1167 aa)
INSRRTyrosine-protein kinase receptor. (1300 aa)
MYL5Myosin light chain 5. (289 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1289 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
GIT1GIT ArfGAP 1. (770 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
ITGAEIntegrin subunit alpha E; Belongs to the integrin alpha chain family. (1166 aa)
APC2APC regulator of WNT signaling pathway 2. (2072 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa)
PPP1CCSerine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] (499 aa)
ITGADIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1168 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (405 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (919 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
FGF5Fibroblast growth factor 5; Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. Belongs to the heparin-binding growth factors family. (559 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
DIAPH3Diaphanous related formin 3. (1191 aa)
ARHGAP35Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] (1516 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (117 aa)
MYLK2Myosin light chain kinase 2. (634 aa)
GNA12G protein subunit alpha 12. (294 aa)
ITGB4Integrin beta. (1766 aa)
SSH2Slingshot protein phosphatase 2. (1421 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1063 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
MYL7Uncharacterized protein. (203 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
MYLK4Protein kinase domain-containing protein. (692 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
HRASUncharacterized protein. (189 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ARHGEF1DH domain-containing protein. (976 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
SCINScinderin. (468 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
PAK1Non-specific serine/threonine protein kinase. (552 aa)
RRASRAS related. (293 aa)
SRCTyrosine-protein kinase. (553 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
ARHGEF4-2Uncharacterized protein. (1296 aa)
MARF1Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
FGFR3Fibroblast growth factor receptor 3. (978 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (1002 aa)
ACTN1Actinin alpha 1. (956 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
APCAPC regulator of WNT signaling pathway. (2851 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (335 aa)
PXN-2Uncharacterized protein. (258 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1381 aa)
PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (337 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1033 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1194 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (734 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (423 aa)
PELOIntegrin subunit alpha 1; Belongs to the integrin alpha chain family. (1208 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (341 aa)
MYL10Myosin light chain 10. (187 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1084 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1981 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2112 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (181 aa)
DIAPH2Diaphanous related formin 2. (1106 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (740 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (892 aa)
MSNMoesin. (592 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (811 aa)
MYLKMyosin light chain kinase. (2017 aa)
MYL12BUncharacterized protein. (259 aa)
CDC42-2Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1621 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2077 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (386 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1209 aa)
ENAHENAH actin regulator. (835 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1601 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (807 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2072 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1186 aa)
VAV3Vav guanine nucleotide exchange factor 3. (859 aa)
PAK2Non-specific serine/threonine protein kinase. (718 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (441 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1283 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1178 aa)
MYL2Myosin light chain 2. (175 aa)
ENSCAFP00000066193Uncharacterized protein. (114 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (200 aa)
ARPC3-2Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (143 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1733 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
WASLWASP like actin nucleation promoting factor. (524 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2586 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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