STRINGSTRING
MAPK12 MAPK12 ADCY8 ADCY8 CDC23 CDC23 CDC25C CDC25C MAPK13 MAPK13 HSP90AB1 HSP90AB1 PGR PGR ADCY3 ADCY3 CCNA2 CCNA2 PIK3R3 PIK3R3 RAF1 RAF1 AKT2 AKT2 ANAPC11 ANAPC11 CCNA1 CCNA1 ANAPC10 ANAPC10 PIK3CB PIK3CB PIK3R1 PIK3R1 ANAPC5 ANAPC5 ANAPC7 ANAPC7 MAPK10 MAPK10 ADCY2 ADCY2 ADCY4 ADCY4 RPS6KA1 RPS6KA1 CDK1 CDK1 CDC25A CDC25A RPS6KA3 RPS6KA3 CDC27 CDC27 PIK3R2 PIK3R2 ARAF ARAF AKT3 AKT3 GNAI1 GNAI1 ANAPC4 ANAPC4 MAD2L1 MAD2L1 MAD1L1 MAD1L1 MAD2L2 MAD2L2 CCNB2 CCNB2 KIF22 KIF22 HSP90AA1 HSP90AA1 AKT1 AKT1 ANAPC2 ANAPC2 PIK3CD PIK3CD GNAI3 GNAI3 PRKACB PRKACB CCNB1 CCNB1 LOC100682940 LOC100682940 MAPK1 MAPK1 GNAI2 GNAI2 AURKA AURKA PLK1 PLK1 ADCY6 ADCY6 CDC26 CDC26 SPDYA SPDYA ADCY9 ADCY9 SPDYC SPDYC IGF1R IGF1R MAP2K1 MAP2K1 CPEB3 CPEB3 CPEB2 CPEB2 MAPK8 MAPK8 MAPK14 MAPK14 PIK3CA PIK3CA RPS6KA2 RPS6KA2 ANAPC13 ANAPC13 INS INS PRKACA PRKACA ANAPC1 ANAPC1 IGF1 IGF1 BUB1 BUB1 CPEB1 CPEB1 MAPK11 MAPK11 CCNB3 CCNB3 MAPK9 MAPK9 STK10 STK10 PDE3B PDE3B CPEB4 CPEB4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK12Mitogen-activated protein kinase. (366 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CDC23Cell division cycle 23. (597 aa)
CDC25CCell division cycle 25C. (476 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. (939 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PIK3R3Uncharacterized protein. (461 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
ANAPC11Anaphase promoting complex subunit 11. (458 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (197 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1051 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (876 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CDC25ACell division cycle 25A. (524 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (717 aa)
CDC27Cell division cycle 27. (831 aa)
PIK3R2Uncharacterized protein. (726 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (605 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNAI1G protein subunit alpha i1. (337 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
MAD2L1HORMA domain-containing protein. (267 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (740 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (196 aa)
CCNB2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (397 aa)
KIF22Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (664 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (542 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (1143 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
CCNB1Uncharacterized protein; Belongs to the cyclin family. (425 aa)
LOC100682940Uncharacterized protein. (317 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). (355 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of prot [...] (1291 aa)
CDC26Cell division cycle 26. (85 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (305 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
SPDYCSpeedy/RINGO cell cycle regulator family member C. (247 aa)
IGF1RTyrosine-protein kinase receptor. (1403 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (715 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (712 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
ANAPC13Anaphase promoting complex subunit 13. (74 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)
ANAPC1Anaphase promoting complex subunit 1. (1973 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1245 aa)
CPEB1RRM domain-containing protein. (802 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
CCNB3G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I (By similarity). (1352 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
STK10Serine/threonine kinase 10. (996 aa)
PDE3BPhosphodiesterase. (1069 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (742 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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