STRINGSTRING
GRM1 GRM1 ESR1 ESR1 HSPA1L HSPA1L EBAG9 EBAG9 ADCY8 ADCY8 ATF4 ATF4 FKBP5 FKBP5 HSP90AB1 HSP90AB1 SHC3 SHC3 CALM2 CALM2 TGFA TGFA EGFR EGFR PGR PGR NCOA1 NCOA1 ADCY3 ADCY3 POMC POMC F1PIN6_CANLF F1PIN6_CANLF PIK3R3 PIK3R3 RAF1 RAF1 CALML5 CALML5 AKT2 AKT2 PLCB4 PLCB4 ITPR1 ITPR1 SOS1 SOS1 SP1 SP1 RARA RARA KRT18 KRT18 PIK3CB PIK3CB PIK3R1 PIK3R1 PRKCD PRKCD PLCB2 PLCB2 KCNJ3 KCNJ3 CREB3L1 CREB3L1 MMP2 MMP2 NRAS NRAS CTSD CTSD KCNJ5 KCNJ5 ADCY2 ADCY2 ITPR2 ITPR2 HSPA8 HSPA8 GPER1 GPER1 ADCY4 ADCY4 ATF2 ATF2 CREB1 CREB1 SOS2 SOS2 SHC4 SHC4 PIK3R2 PIK3R2 FKBP4 FKBP4 AKT3 AKT3 ESR2 ESR2 KRT13 KRT13 KRT25 KRT25 KRT36 KRT36 KRT35 KRT35 KRT32 KRT32 LOC490986 LOC490986 KRT33B KRT33B KRT31 KRT31 KRT41 KRT41 KRT33A KRT33A KRT40 KRT40 KRT23 KRT23 KRT12 KRT12 KRT10 KRT10 KRT28 KRT28 KRT27 KRT27 KRT26 KRT26 KRT24 KRT24 HSPA2 HSPA2 GNAI1 GNAI1 FOS FOS SHC1 SHC1 CALML4 CALML4 HSP90AA1 HSP90AA1 AKT1 AKT1 CALML6 CALML6 GNAQ GNAQ SHC2 SHC2 PIK3CD PIK3CD GNAI3 GNAI3 PRKACB PRKACB KRT39 KRT39 MAPK1 MAPK1 GNAI2 GNAI2 KRT20 KRT20 MMP9 MMP9 PLCB3 PLCB3 KCNJ9 KCNJ9 ADCY6 ADCY6 HRAS HRAS ADCY9 ADCY9 CREB3L4 CREB3L4 MAP2K2 MAP2K2 SRC SRC MAP2K1 MAP2K1 OPRM1 OPRM1 PIK3CA PIK3CA ITPR3 ITPR3 GRB2 GRB2 TFF1 TFF1 HBEGF HBEGF GABBR2 GABBR2 KCNJ6 KCNJ6 PRKACA PRKACA HSP90B1 HSP90B1 PLCB1 PLCB1 CREB5 CREB5 NOS3 NOS3 KRT37 KRT37 NCOA2 NCOA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRM1Glutamate metabotropic receptor 1. (1195 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (661 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ATF4Activating transcription factor 4. (350 aa)
FKBP5Peptidylprolyl isomerase. (456 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
SHC3SHC adaptor protein 3. (458 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
TGFAEGF-like domain-containing protein. (284 aa)
EGFRReceptor protein-tyrosine kinase. (1141 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. (939 aa)
NCOA1Nuclear receptor coactivator. (1410 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
POMCProopiomelanocortin. (264 aa)
F1PIN6_CANLFUncharacterized protein; Belongs to the calmodulin family. (364 aa)
PIK3R3Uncharacterized protein. (461 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CALML5Calmodulin like 5. (169 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2628 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
SP1Sp1 transcription factor. (782 aa)
RARARetinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcri [...] (462 aa)
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCDProtein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of [...] (674 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
MMP2Matrix metallopeptidase 2. (610 aa)
NRASUncharacterized protein. (189 aa)
CTSDCathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. (410 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1051 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (384 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa)
SHC4SHC adaptor protein 4. (632 aa)
PIK3R2Uncharacterized protein. (726 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ESR2Estrogen receptor 2. (549 aa)
KRT13IF rod domain-containing protein; Belongs to the intermediate filament family. (531 aa)
KRT25IF rod domain-containing protein; Belongs to the intermediate filament family. (450 aa)
KRT36Keratin 36; Belongs to the intermediate filament family. (467 aa)
KRT35Keratin 35; Belongs to the intermediate filament family. (455 aa)
KRT32Keratin 32; Belongs to the intermediate filament family. (446 aa)
LOC490986IF rod domain-containing protein; Belongs to the intermediate filament family. (457 aa)
KRT33BIF rod domain-containing protein; Belongs to the intermediate filament family. (407 aa)
KRT31IF rod domain-containing protein; Belongs to the intermediate filament family. (409 aa)
KRT41IF rod domain-containing protein; Belongs to the intermediate filament family. (437 aa)
KRT33AIF rod domain-containing protein; Belongs to the intermediate filament family. (404 aa)
KRT40IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa)
KRT23IF rod domain-containing protein; Belongs to the intermediate filament family. (419 aa)
KRT12Keratin 12; Belongs to the intermediate filament family. (507 aa)
KRT10Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin; Belongs to the intermediate filament family. (568 aa)
KRT28IF rod domain-containing protein; Belongs to the intermediate filament family. (464 aa)
KRT27IF rod domain-containing protein; Belongs to the intermediate filament family. (446 aa)
KRT26IF rod domain-containing protein; Belongs to the intermediate filament family. (464 aa)
KRT24Keratin 24; Belongs to the intermediate filament family. (535 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (637 aa)
GNAI1G protein subunit alpha i1. (337 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SHC1SHC adaptor protein 1. (577 aa)
CALML4Calmodulin like 4. (120 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (542 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CALML6Calmodulin like 6. (156 aa)
GNAQGuanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa)
SHC2Uncharacterized protein. (636 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
KRT39Keratin 39; Belongs to the intermediate filament family. (483 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). (355 aa)
KRT20Keratin 20; Belongs to the intermediate filament family. (434 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (732 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (339 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of prot [...] (1291 aa)
HRASUncharacterized protein. (189 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (382 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
SRCTyrosine-protein kinase. (553 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
OPRM1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (419 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2689 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
TFF1Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. (102 aa)
HBEGFHeparin binding EGF like growth factor. (263 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (958 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (461 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family. (805 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
CREB5cAMP responsive element binding protein 5. (552 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1256 aa)
KRT37IF rod domain-containing protein; Belongs to the intermediate filament family. (449 aa)
NCOA2Nuclear receptor coactivator 2. (1568 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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