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KCNN2 KCNN2 ADCY8 ADCY8 ABCB4 ABCB4 SLC2A1 SLC2A1 ABCG5 ABCG5 BAAT BAAT CFTR CFTR ADCY3 ADCY3 SCTR SCTR SLC10A2 SLC10A2 NR1H4 NR1H4 ATP1B3 ATP1B3 ABCC2 ABCC2 ABCG2 ABCG2 ADCY2 ADCY2 SLC9A1 SLC9A1 NR0B2 NR0B2 ADCY4 ADCY4 SLCO1A2 SLCO1A2 SLC51A SLC51A ATP1B1 ATP1B1 SLC22A8 SLC22A8 AQP9 AQP9 SLC10A1 SLC10A1 SLC51B SLC51B ABCC3 ABCC3 AQP8 AQP8 AQP4 AQP4 ATP1B4 ATP1B4 PRKACB PRKACB LOC100686607 LOC100686607 LOC480777 LOC480777 LOC100856068 LOC100856068 ABCB11 ABCB11 ADCY6 ADCY6 NCEH1 NCEH1 ADCY9 ADCY9 LDLR LDLR CYP7A1 CYP7A1 ATP1B2 ATP1B2 SLC4A2 SLC4A2 ATP1A1 ATP1A1 EPHX1 EPHX1 SLC4A5 SLC4A5 CA2 CA2 PRKACA PRKACA SLC22A1 SLC22A1 ABCG8 ABCG8 SLCO1B3 SLCO1B3 SCARB1 SCARB1 SLC4A4 SLC4A4 RXRA RXRA SLC5A1 SLC5A1 HMGCR HMGCR ABCB1 ABCB1 FXYD2 FXYD2 ATP1A3 ATP1A3 ABCC4 ABCC4 UGT1A6 UGT1A6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNN2Potassium calcium-activated channel subfamily N member 2. (981 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ABCB4ATP binding cassette subfamily B member 4. (1166 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (807 aa)
ABCG5ATP binding cassette subfamily G member 5. (652 aa)
BAATBile acid-CoA:amino acid N-acyltransferase. (422 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1483 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
SCTRSecretin receptor; Belongs to the G-protein coupled receptor 2 family. (419 aa)
SLC10A2Ileal sodium/bile acid cotransporter. (348 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (485 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (264 aa)
ABCC2ATP binding cassette subfamily C member 2. (1544 aa)
ABCG2ATP binding cassette subfamily G member 2. (655 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1051 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (276 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
SLCO1A2Solute carrier organic anion transporter family member. (670 aa)
SLC51ASolute carrier family 51 alpha subunit. (353 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (299 aa)
SLC22A8Solute carrier family 22 member 8. (607 aa)
AQP9Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
SLC10A1Solute carrier family 10 member 1. (392 aa)
SLC51BSolute carrier family 51 beta subunit. (132 aa)
ABCC3ATP binding cassette subfamily C member 3. (1523 aa)
AQP8Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (348 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (366 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
LOC100686607UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (438 aa)
LOC480777UDP-glucuronosyltransferase 2B31; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs. (530 aa)
LOC100856068UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
ABCB11ATP binding cassette subfamily B member 11. (1325 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of prot [...] (1291 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (408 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
LDLRLow density lipoprotein receptor. (888 aa)
CYP7A1Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family. (604 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (299 aa)
SLC4A2Anion exchange protein. (1377 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. (1120 aa)
EPHX1Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (479 aa)
SLC4A5Anion exchange protein. (1152 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (295 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)
SLC22A1Uncharacterized protein. (177 aa)
ABCG8ATP binding cassette subfamily G member 8. (707 aa)
SLCO1B3Solute carrier organic anion transporter family member. (701 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (552 aa)
SLC4A4Anion exchange protein. (1096 aa)
RXRARetinoid X receptor alpha. (556 aa)
SLC5A1Sodium-glucose cotransporter-like 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (662 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (935 aa)
ABCB1ATP binding cassette subfamily B member 1. (1321 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (98 aa)
ATP1A3ATPase Na+/K+ transporting subunit alpha 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1384 aa)
ABCC4ATP binding cassette subfamily C member 4. (1314 aa)
UGT1A6UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (570 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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