STRINGSTRING
IL23A IL23A TICAM2 TICAM2 TNF TNF MAPK12 MAPK12 C2 C2 IRF1 IRF1 MAPK13 MAPK13 CALM2 CALM2 CXCL8 CXCL8 NOD1 NOD1 C5 C5 IRF3 IRF3 ITGB1 ITGB1 F1PIN6_CANLF F1PIN6_CANLF MYD88 MYD88 CALML5 CALML5 ITGA5 ITGA5 TRAF6 TRAF6 IL1B IL1B CASP3 CASP3 MAPK10 MAPK10 IRAK4 IRAK4 NLRP3 NLRP3 CASP7 CASP7 F1Q1C8_CANLF F1Q1C8_CANLF IL10 IL10 C4BPA C4BPA RELA RELA IL12A IL12A C1R C1R C1QC C1QC LOC610540 LOC610540 GNAI1 GNAI1 PYCARD PYCARD FOS FOS IL12B IL12B CALML4 CALML4 C3 C3 NOS2 NOS2 CALML6 CALML6 GNAI3 GNAI3 RHOA RHOA TIRAP TIRAP MAPK1 MAPK1 TLR4 TLR4 GNAI2 GNAI2 TICAM1 TICAM1 CXCL6 CXCL6 IL1A IL1A C4BPB C4BPB C1QB C1QB C1QA C1QA LOC481722 LOC481722 C1S C1S MAPK8 MAPK8 MAPK14 MAPK14 IRF8 IRF8 IL6 IL6 NFKB1 NFKB1 MAPK11 MAPK11 MAPK9 MAPK9 CFL1 CFL1 CFL2 CFL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL23AInterleukin 23 subunit alpha. (193 aa)
TICAM2TIR domain-containing protein. (238 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MAPK12Mitogen-activated protein kinase. (366 aa)
C2Complement C2; Belongs to the peptidase S1 family. (780 aa)
IRF1Interferon regulatory factor 1. (437 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (964 aa)
C5Complement C5. (1611 aa)
IRF3Interferon regulatory factor 3. (281 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (820 aa)
F1PIN6_CANLFUncharacterized protein; Belongs to the calmodulin family. (364 aa)
MYD88MYD88 innate immune signal transduction adaptor. (398 aa)
CALML5Calmodulin like 5. (169 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1053 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (466 aa)
NLRP3NLR family pyrin domain containing 3. (1065 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (300 aa)
F1Q1C8_CANLFADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (207 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa)
C4BPAComplement component 4 binding protein alpha. (606 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (719 aa)
C1QCComplement C1q C chain. (235 aa)
LOC610540Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. (277 aa)
GNAI1G protein subunit alpha i1. (337 aa)
PYCARDPYD and CARD domain containing. (195 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
CALML4Calmodulin like 4. (120 aa)
C3Complement C3. (1566 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1157 aa)
CALML6Calmodulin like 6. (156 aa)
GNAI3G protein subunit alpha i3. (354 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa)
TIRAPTIR domain containing adaptor protein. (406 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). (355 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa)
CXCL6C-X-C motif chemokine. (115 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (273 aa)
C4BPBComplement component 4 binding protein beta. (255 aa)
C1QBComplement C1q B chain. (250 aa)
C1QAComplement C1q A chain. (264 aa)
LOC481722Uncharacterized protein. (1738 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (696 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
IRF8Interferon regulatory factor 8. (460 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (200 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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